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Severe acute respiratory syndrome coronavirus envelope protein ion channel activity promotes virus fitness and pathogenesis.
Nieto-Torres JL, DeDiego ML, Verdiá-Báguena C, Jimenez-Guardeño JM, Regla-Nava JA, Fernandez-Delgado R, Castaño-Rodriguez C, Alcaraz A, Torres J, Aguilella VM, Enjuanes L. Nieto-Torres JL, et al. PLoS Pathog. 2014 May 1;10(5):e1004077. doi: 10.1371/journal.ppat.1004077. eCollection 2014 May. PLoS Pathog. 2014. PMID: 24788150 Free PMC article.
Coronavirus virulence genes with main focus on SARS-CoV envelope gene.
DeDiego ML, Nieto-Torres JL, Jimenez-Guardeño JM, Regla-Nava JA, Castaño-Rodriguez C, Fernandez-Delgado R, Usera F, Enjuanes L. DeDiego ML, et al. Virus Res. 2014 Dec 19;194:124-37. doi: 10.1016/j.virusres.2014.07.024. Epub 2014 Aug 2. Virus Res. 2014. PMID: 25093995 Free PMC article. Review.
Severe acute respiratory syndrome coronavirus E protein transports calcium ions and activates the NLRP3 inflammasome.
Nieto-Torres JL, Verdiá-Báguena C, Jimenez-Guardeño JM, Regla-Nava JA, Castaño-Rodriguez C, Fernandez-Delgado R, Torres J, Aguilella VM, Enjuanes L. Nieto-Torres JL, et al. Among authors: castano rodriguez c. Virology. 2015 Nov;485:330-9. doi: 10.1016/j.virol.2015.08.010. Epub 2015 Aug 29. Virology. 2015. PMID: 26331680 Free PMC article.
Identification of the Mechanisms Causing Reversion to Virulence in an Attenuated SARS-CoV for the Design of a Genetically Stable Vaccine.
Jimenez-Guardeño JM, Regla-Nava JA, Nieto-Torres JL, DeDiego ML, Castaño-Rodriguez C, Fernandez-Delgado R, Perlman S, Enjuanes L. Jimenez-Guardeño JM, et al. Among authors: castano rodriguez c. PLoS Pathog. 2015 Oct 29;11(10):e1005215. doi: 10.1371/journal.ppat.1005215. eCollection 2015 Oct. PLoS Pathog. 2015. PMID: 26513244 Free PMC article.
Molecular Basis of Coronavirus Virulence and Vaccine Development.
Enjuanes L, Zuñiga S, Castaño-Rodriguez C, Gutierrez-Alvarez J, Canton J, Sola I. Enjuanes L, et al. Among authors: castano rodriguez c. Adv Virus Res. 2016;96:245-286. doi: 10.1016/bs.aivir.2016.08.003. Epub 2016 Aug 30. Adv Virus Res. 2016. PMID: 27712626 Free PMC article. Review.
Role of Severe Acute Respiratory Syndrome Coronavirus Viroporins E, 3a, and 8a in Replication and Pathogenesis.
Castaño-Rodriguez C, Honrubia JM, Gutiérrez-Álvarez J, DeDiego ML, Nieto-Torres JL, Jimenez-Guardeño JM, Regla-Nava JA, Fernandez-Delgado R, Verdia-Báguena C, Queralt-Martín M, Kochan G, Perlman S, Aguilella VM, Sola I, Enjuanes L. Castaño-Rodriguez C, et al. mBio. 2018 May 22;9(3):e02325-17. doi: 10.1128/mBio.02325-17. mBio. 2018. PMID: 29789363 Free PMC article.
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