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The response of plasma von Willebrand factor to desmopressin (DDAVP) is related to the platelet levels of von Willebrand factor.
Lattuada A, Varanukulsak P, Castaman GC, Mannucci PM. Lattuada A, et al. Thromb Res. 1992 Aug 15;67(4):467-71. doi: 10.1016/0049-3848(92)90276-g. Thromb Res. 1992. PMID: 1412225 No abstract available.
Effectiveness of high-dose intravenous immunoglobulin in a case of acquired von Willebrand syndrome with chronic melena not responsive to desmopressin and factor VIII concentrate.
Castaman G, Tosetto A, Rodeghiero F. Castaman G, et al. Am J Hematol. 1992 Oct;41(2):132-6. doi: 10.1002/ajh.2830410212. Am J Hematol. 1992. PMID: 1415174
After intravenous Ig (1 g/kg for 2 days), VIII/vWF measurements, hemostatic parameters and multimeric pattern were completely corrected (VIII/C 106 IU/dl, vWF:Ag 168 IU/dl, RiCof 147 IU/dl, APTT ratio 0.89, BT 5'), with a return to pre-infusion values after 15 days. ...
After intravenous Ig (1 g/kg for 2 days), VIII/vWF measurements, hemostatic parameters and multimeric pattern were completely correct …
In vivo experiments indicate that relatively high platelet deposition in von Willebrand's disease 'Vicenza' is caused by normal platelet-VWF levels rather than by high VWF-multimers in plasma.
d'Alessio PA, Castaman G, Rodeghiero F, de Boer HC, Federici AB, Mannucci PM, de Groot PG, Sixma JJ, Zwaginga JJ. d'Alessio PA, et al. Thromb Res. 1992 Jan 15;65(2):221-8. doi: 10.1016/0049-3848(92)90242-3. Thromb Res. 1992. PMID: 1579897
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