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Screening and adenocarcinoma of the cervix.
Sasieni P, Castanon A, Cuzick J. Sasieni P, et al. Int J Cancer. 2009 Aug 1;125(3):525-9. doi: 10.1002/ijc.24410. Int J Cancer. 2009. PMID: 19449379
A population-based case-control design was used in women aged 20-69 in the United Kingdom, with information on screening obtained from routine databases. ...Incidence of adenocarcinoma was low within 2.5 years of a negative smear (OR 2.3, 95%CI 0.15-0.34), but was n
A population-based case-control design was used in women aged 20-69 in the United Kingdom, with information on screening obtained fro
How many cervical cancers are prevented by treatment of screen-detected disease in young women?
Sasieni P, Castanon A, Parkin DM. Sasieni P, et al. Int J Cancer. 2009 Jan 15;124(2):461-4. doi: 10.1002/ijc.23922. Int J Cancer. 2009. PMID: 18844220
Others have argued that as many as a third of women treated for high-grade cervical intraepithelial neoplasia (CIN) would have developed cervical cancer in the absence of screening and treatment. ...
Others have argued that as many as a third of women treated for high-grade cervical intraepithelial neoplasia (CIN) would have develo …
Effectiveness of cervical screening with age: population based case-control study of prospectively recorded data.
Sasieni P, Castanon A, Cuzick J. Sasieni P, et al. BMJ. 2009 Jul 28;339:b2968. doi: 10.1136/bmj.b2968. BMJ. 2009. PMID: 19638651 Free PMC article. Clinical Trial.
OBJECTIVE: To study the effect of cervical screening on incidence of cervical cancer as a function of age with particular focus on women screened under the age of 25. ...Screening was associated with a 60% reduction of cancers in women aged 40, increasing to 80% at …
OBJECTIVE: To study the effect of cervical screening on incidence of cervical cancer as a function of age with particular focus on wo …
Predicted impact of vaccination against human papillomavirus 16/18 on cancer incidence and cervical abnormalities in women aged 20-29 in the UK.
Cuzick J, Castañón A, Sasieni P. Cuzick J, et al. Br J Cancer. 2010 Mar 2;102(5):933-9. doi: 10.1038/sj.bjc.6605528. Epub 2010 Jan 26. Br J Cancer. 2010. PMID: 20104226 Free PMC article.
METHODS: We modelled the proportion of abnormal smears, cervical intraepithelial neoplasia grade 3 (CIN3) and invasive cancer, which will be prevented in women aged 20-29 in the UK as a result of HPV vaccination. ...With 80% coverage in women aged 12-13, we project an even …
METHODS: We modelled the proportion of abnormal smears, cervical intraepithelial neoplasia grade 3 (CIN3) and invasive cancer, which will be …
Single negative colposcopy: is it enough to rule out high-grade disease?
Mesher D, Tristram A, Castanon A, Beer H, Ashman S, Fielder H, Fiander A, Sasieni P. Mesher D, et al. J Med Screen. 2011;18(3):160-1. doi: 10.1258/jms.2011.011097. J Med Screen. 2011. PMID: 22045826 Clinical Trial.
We present data regarding 551 women who had colposcopy in Wales for a low-grade cytological abnormality and who were followed through Cervical Screening Wales for subsequent CIN. ...We suggest that additional screening at an interval of less than three years should be offe …
We present data regarding 551 women who had colposcopy in Wales for a low-grade cytological abnormality and who were followed through …
Effect of diindolylmethane supplementation on low-grade cervical cytological abnormalities: double-blind, randomised, controlled trial.
Castañon A, Tristram A, Mesher D, Powell N, Beer H, Ashman S, Rieck G, Fielder H, Fiander A, Sasieni P. Castañon A, et al. Br J Cancer. 2012 Jan 3;106(1):45-52. doi: 10.1038/bjc.2011.496. Epub 2011 Nov 10. Br J Cancer. 2012. PMID: 22075942 Free PMC article. Clinical Trial.
We report on a randomised controlled trial of the effect of DIM in women with low-grade cervical cytological abnormalities. METHODS: We conducted a pragmatic double-blind, randomised controlled trial of 150 mg DIM (from BioResponse DIM) or placebo daily for 6 months …
We report on a randomised controlled trial of the effect of DIM in women with low-grade cervical cytological abnormalities. METHODS: …
Review of cytology and histopathology as part of the NHS Cervical Screening Programme audit of invasive cervical cancers.
Castanon A, Ferryman S, Patnick J, Sasieni P. Castanon A, et al. Cytopathology. 2012 Feb;23(1):13-22. doi: 10.1111/j.1365-2303.2011.00948.x. Cytopathology. 2012. PMID: 22243289
CONCLUSIONS: In spite of the excellent quality of cytology in England, a high proportion of negative cytology taken up to three and a half years before diagnosis were considered to contain abnormal cells by reviewers informed of the subsequent cancer. Continuing the …
CONCLUSIONS: In spite of the excellent quality of cytology in England, a high proportion of negative cytology taken up to three and …
Risk of preterm birth after treatment for cervical intraepithelial neoplasia among women attending colposcopy in England: retrospective-prospective cohort study.
Castanon A, Brocklehurst P, Evans H, Peebles D, Singh N, Walker P, Patnick J, Sasieni P; PaCT Study Group. Castanon A, et al. BMJ. 2012 Aug 16;345:e5174. doi: 10.1136/bmj.e5174. BMJ. 2012. PMID: 22899563 Free PMC article.
PARTICIPANTS: Women who had a cervical histology sample taken between 1987 and 2009. These women were linked by hospital episode statistics to hospital obstetric records between 1998 and 2009 for the whole of England to identify singleton live births between 20-43 gestatio …
PARTICIPANTS: Women who had a cervical histology sample taken between 1987 and 2009. These women were linked by hospital episode stat …
Dramatic increase in cervical cancer registrations in young women in 2009 in England unlikely to be due to the new policy not to screen women aged 20-24.
Sasieni P, Castanon A. Sasieni P, et al. J Med Screen. 2012 Sep;19(3):127-32. doi: 10.1258/jms.2012.012081. J Med Screen. 2012. PMID: 23093730
RESULTS: In England there was a 38% (95% confidence intervals [CI] 18-62%) increase in cervical cancer incidence rates in women aged 25-29 in 2009 relative to 2008, and a 30% (11-51%) increase in women aged 35-39. ...In England there has been a gradual increa …
RESULTS: In England there was a 38% (95% confidence intervals [CI] 18-62%) increase in cervical cancer incidence rates in women aged …
HPV16 L1 and L2 DNA methylation predicts high-grade cervical intraepithelial neoplasia in women with mildly abnormal cervical cytology.
Lorincz AT, Brentnall AR, Vasiljević N, Scibior-Bentkowska D, Castanon A, Fiander A, Powell N, Tristram A, Cuzick J, Sasieni P. Lorincz AT, et al. Int J Cancer. 2013 Aug 1;133(3):637-44. doi: 10.1002/ijc.28050. Epub 2013 Mar 7. Int J Cancer. 2013. PMID: 23335178 Free PMC article. Clinical Trial.
Exfoliated cervical cells at baseline and 6-months follow-up were analyzed in 84 women selected from a randomized clinical trial of women undergoing surveillance for low-grade cytology. ...The primary measure was a predefined score combining the mean methylation in …
Exfoliated cervical cells at baseline and 6-months follow-up were analyzed in 84 women selected from a randomized clinical trial of w …
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