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Oleuropein and its peracetylated derivative negatively regulate osteoclastogenesis by controlling the expression of genes involved in osteoclast differentiation and function.
Rosillo MA , Montserrat-de-la-Paz S , Abia R , Castejon ML , Millan-Linares MC , Alarcon-de-la-Lastra C , Fernandez-Bolaños JG , Muriana FJG . Rosillo MA , et al. Among authors: castejon ml. Food Funct. 2020 May 1;11(5):4038-4048. doi: 10.1039/d0fo00433b. Epub 2020 Apr 23. Food Funct. 2020. PMID: 32323697
A New Peracetylated Oleuropein Derivative Ameliorates Joint Inflammation and Destruction in a Murine Collagen-Induced Arthritis Model via Activation of the Nrf-2/Ho-1 Antioxidant Pathway and Suppression of MAPKs and NF-κB Activation.
Castejón ML, Alarcón-de-la-Lastra C, Rosillo MÁ, Montoya T, Fernández-Bolaños JG, González-Benjumea A, Sánchez-Hidalgo M. Castejón ML, et al. Nutrients. 2021 Jan 22;13(2):311. doi: 10.3390/nu13020311. Nutrients. 2021. PMID: 33499113 Free PMC article.
Dietary oleuropein and its new acyl-derivate attenuate murine lupus nephritis through HO-1/Nrf2 activation and suppressing JAK/STAT, NF-κB, MAPK and NLRP3 inflammasome signaling pathways.
Castejon ML, Sánchez-Hidalgo M, Aparicio-Soto M, Montoya T, Martín-LaCave I, Fernández-Bolaños JG, Alarcón-de-la-Lastra C. Castejon ML, et al. J Nutr Biochem. 2019 Dec;74:108229. doi: 10.1016/j.jnutbio.2019.108229. Epub 2019 Sep 13. J Nutr Biochem. 2019. PMID: 31698204
Peracetylated hydroxytyrosol, a new hydroxytyrosol derivate, attenuates LPS-induced inflammatory response in murine peritoneal macrophages via regulation of non-canonical inflammasome, Nrf2/HO1 and JAK/STAT signaling pathways.
Montoya T, Aparicio-Soto M, Castejón ML, Rosillo MÁ, Sánchez-Hidalgo M, Begines P, Fernández-Bolaños JG, Alarcón-de-la-Lastra C. Montoya T, et al. Among authors: castejon ml. J Nutr Biochem. 2018 Jul;57:110-120. doi: 10.1016/j.jnutbio.2018.03.014. Epub 2018 Mar 18. J Nutr Biochem. 2018. PMID: 29694939
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