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RNA interference in the nucleus: roles for small RNAs in transcription, epigenetics and beyond.
Castel SE, Martienssen RA. Castel SE, et al. Nat Rev Genet. 2013 Feb;14(2):100-12. doi: 10.1038/nrg3355. Nat Rev Genet. 2013. PMID: 23329111 Free PMC article. Review.
RNAi promotes heterochromatic silencing through replication-coupled release of RNA Pol II.
Zaratiegui M, Castel SE, Irvine DV, Kloc A, Ren J, Li F, de Castro E, Marín L, Chang AY, Goto D, Cande WZ, Antequera F, Arcangioli B, Martienssen RA. Zaratiegui M, et al. Among authors: castel se. Nature. 2011 Oct 16;479(7371):135-8. doi: 10.1038/nature10501. Nature. 2011. PMID: 22002604 Free PMC article.
Dicer promotes transcription termination at sites of replication stress to maintain genome stability.
Castel SE, Ren J, Bhattacharjee S, Chang AY, Sánchez M, Valbuena A, Antequera F, Martienssen RA. Castel SE, et al. Cell. 2014 Oct 23;159(3):572-83. doi: 10.1016/j.cell.2014.09.031. Epub 2014 Oct 16. Cell. 2014. PMID: 25417108 Free PMC article.
Dicer in action at replication-transcription collisions.
Ren J, Castel SE, Martienssen RA. Ren J, et al. Among authors: castel se. Mol Cell Oncol. 2015 Mar 9;2(3):e991224. doi: 10.4161/23723556.2014.991224. eCollection 2015 Jul-Sep. Mol Cell Oncol. 2015. PMID: 27308471 Free PMC article.
Oncogenic transformation of Drosophila somatic cells induces a functional piRNA pathway.
Fagegaltier D, Falciatori I, Czech B, Castel S, Perrimon N, Simcox A, Hannon GJ. Fagegaltier D, et al. Genes Dev. 2016 Jul 15;30(14):1623-35. doi: 10.1101/gad.284927.116. Genes Dev. 2016. PMID: 27474441 Free PMC article.
The Conserved RNA Binding Cyclophilin, Rct1, Regulates Small RNA Biogenesis and Splicing Independent of Heterochromatin Assembly.
Chang AY, Castel SE, Ernst E, Kim HS, Martienssen RA. Chang AY, et al. Among authors: castel se. Cell Rep. 2017 Jun 20;19(12):2477-2489. doi: 10.1016/j.celrep.2017.05.086. Cell Rep. 2017. PMID: 28636937 Free PMC article.
Modified penetrance of coding variants by cis-regulatory variation contributes to disease risk.
Castel SE, Cervera A, Mohammadi P, Aguet F, Reverter F, Wolman A, Guigo R, Iossifov I, Vasileva A, Lappalainen T. Castel SE, et al. Nat Genet. 2018 Sep;50(9):1327-1334. doi: 10.1038/s41588-018-0192-y. Epub 2018 Aug 20. Nat Genet. 2018. PMID: 30127527 Free PMC article.
Rare variant phasing and haplotypic expression from RNA sequencing with phASER.
Castel SE, Mohammadi P, Chung WK, Shen Y, Lappalainen T. Castel SE, et al. Nat Commun. 2016 Sep 8;7:12817. doi: 10.1038/ncomms12817. Nat Commun. 2016. PMID: 27605262 Free PMC article.
Genetic regulatory effects modified by immune activation contribute to autoimmune disease associations.
Kim-Hellmuth S, Bechheim M, Pütz B, Mohammadi P, Nédélec Y, Giangreco N, Becker J, Kaiser V, Fricker N, Beier E, Boor P, Castel SE, Nöthen MM, Barreiro LB, Pickrell JK, Müller-Myhsok B, Lappalainen T, Schumacher J, Hornung V. Kim-Hellmuth S, et al. Among authors: castel se. Nat Commun. 2017 Aug 16;8(1):266. doi: 10.1038/s41467-017-00366-1. Nat Commun. 2017. PMID: 28814792 Free PMC article.
Quantifying the regulatory effect size of cis-acting genetic variation using allelic fold change.
Mohammadi P, Castel SE, Brown AA, Lappalainen T. Mohammadi P, et al. Among authors: castel se. Genome Res. 2017 Nov;27(11):1872-1884. doi: 10.1101/gr.216747.116. Epub 2017 Oct 11. Genome Res. 2017. PMID: 29021289 Free PMC article.
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