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Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns
Czamara D, et al. Nat Commun 2019. PMID 31186427 Free PMC article.
We use Akaike's information criterion to test which factors best explain variability of methylation in the cohort-specific VMRs: several prenatal environmental factors (E), genotypes in cis (G), or their additive (G + E) or interaction (GxE) effects. ...The CpGs best explained by either G, G + E or GxE are functionally distinct. The enrichment of genetic variants from GxE models in GWAS for complex disorders supports their importance for disease risk....
We use Akaike's information criterion to test which factors best explain variability of methylation in the cohort-specific VMRs: several pre …
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