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Exacerbated status epilepticus and acute cell loss, but no changes in epileptogenesis, in mice with increased brain-derived neurotrophic factor signaling.
Lähteinen S, Pitkänen A, Koponen E, Saarelainen T, Castrén E. Lähteinen S, et al. Neuroscience. 2003;122(4):1081-92. doi: 10.1016/j.neuroscience.2003.08.037. Neuroscience. 2003. PMID: 14643774
To study this controversy, we induced S.E. with kainate in transgenic mice with increased BDNF signaling due to trkB overexpression. Transgenic mice experienced a more severe S.E. than wild type animals did. Furthermore, they had increased acute hippocampal neuronal …
To study this controversy, we induced S.E. with kainate in transgenic mice with increased BDNF signaling due to trkB overexpression. …
Expression of c-Met in developing rat hippocampus: evidence for HGF as a neurotrophic factor for calbindin D-expressing neurons.
Korhonen L, Sjöholm U, Takei N, Kern MA, Schirmacher P, Castrén E, Lindholm D. Korhonen L, et al. Eur J Neurosci. 2000 Oct;12(10):3453-61. doi: 10.1046/j.1460-9568.2000.00260.x. Eur J Neurosci. 2000. PMID: 11029614
Chronic antidepressant treatment selectively increases expression of plasticity-related proteins in the hippocampus and medial prefrontal cortex of the rat.
Sairanen M, O'Leary OF, Knuuttila JE, Castrén E. Sairanen M, et al. Neuroscience. 2007 Jan 5;144(1):368-74. doi: 10.1016/j.neuroscience.2006.08.069. Epub 2006 Oct 13. Neuroscience. 2007. PMID: 17049169
The messenger RNAs for both glial cell line-derived neurotrophic factor receptors, c-ret and GDNFRalpha, are induced in the rat brain in response to kainate-induced excitation.
Reeben M, Laurikainen A, Hiltunen JO, Castrén E, Saarma M. Reeben M, et al. Neuroscience. 1998 Mar;83(1):151-9. doi: 10.1016/s0306-4522(97)00361-8. Neuroscience. 1998. PMID: 9466405
Differential effects of neurotrophins on ocular dominance plasticity in developing and adult cat visual cortex.
Galuske RA, Kim DS, Castrén E, Singer W. Galuske RA, et al. Eur J Neurosci. 2000 Sep;12(9):3315-30. doi: 10.1046/j.1460-9568.2000.00213.x. Eur J Neurosci. 2000. PMID: 10998115
Under conditions of equal activation of thalamocortical synapses, i.e. when animals were either subject to binocular deprivation (BD) or reared without deprivation, BDNF infusion did not disrupt binocularity of cortical units, but reversed the natural OD bias towards the c …
Under conditions of equal activation of thalamocortical synapses, i.e. when animals were either subject to binocular deprivation (BD) …
Brain-derived neurotrophic factor promotes the differentiation of various hippocampal nonpyramidal neurons, including Cajal-Retzius cells, in organotypic slice cultures.
Marty S, Carroll P, Cellerino A, Castrén E, Staiger V, Thoenen H, Lindholm D. Marty S, et al. J Neurosci. 1996 Jan 15;16(2):675-87. doi: 10.1523/JNEUROSCI.16-02-00675.1996. J Neurosci. 1996. PMID: 8551351 Free PMC article.
The induction of LTP increases BDNF and NGF mRNA but decreases NT-3 mRNA in the dentate gyrus.
Castrén E, Pitkänen M, Sirviö J, Parsadanian A, Lindholm D, Thoenen H, Riekkinen PJ. Castrén E, et al. Neuroreport. 1993 Jul;4(7):895-8. doi: 10.1097/00001756-199307000-00014. Neuroreport. 1993. PMID: 8396461
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