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Efficacy and Safety of Semaglutide According to Frailty Status: A Post Hoc Analysis of the SELECT Randomized Clinical Trial.
Ostrominski JW, Plutzky J, Scirica BM, Hovingh GK, Jeppesen OK, Lincoff AM, Lingvay I, Hoffmann Morville T, Quiroga M, Sofer Y, Urina-Triana M, Aroda VR; SELECT Trial Investigators. Ostrominski JW, et al. JAMA Cardiol. 2026 Sep 16:e263566. doi: 10.1001/jamacardio.2026.3566. Online ahead of print. JAMA Cardiol. 2026. PMID: 42747817
IMPORTANCE: Whether frailty influences the benefit-risk balance of glucagon-like peptide-1 receptor agonists (GLP-1 RA) is uncertain. OBJECTIVE: To evaluate whether frailty modifies the efficacy and safety of the GLP-1 RA semaglutide in adults with cardiovascular di …
IMPORTANCE: Whether frailty influences the benefit-risk balance of glucagon-like peptide-1 receptor agonists (GLP-1 RA) is uncertain. …
Quality of life in patients with gallbladder polyps: a multicentre prospective cohort study.
Martens SRWJ, van Dooren M, van der Bilt J, de Boer MT, Boerma D, Bos P, Braat AE, de Castro SMM, Corten BJGA, Daams F, Erdmann JI, Ferenschild F, Fortuin AS, van Geloven A, van der Hoeven E, Klicks R, Kruyt FM, Langenhoff BS, Liem MSL, Linsen PVM, Luyer M, Nieuwenhuijs VB, Olthof P, Plaisier PW, van Rossem C, Schrauwen R, Schreinemakers J, Serafino GP, Spillenaar Bilgen EJ, Talsma K, Tielemans MM, Tutein Nolthenius CJ, de Savornin Lohman EAJ, de Reuver PR. Martens SRWJ, et al. HPB (Oxford). 2026 Mar;28(3):359-368. doi: 10.1016/j.hpb.2025.12.008. Epub 2025 Dec 6. HPB (Oxford). 2026. PMID: 41421933 Free article.
QoL was assessed at multiple time points using generic (EQ-5D) and disease-specific (GIQLI) instruments. Demographics, imaging, and surgical data were analysed. ...Anxiety was reported by 39 % and was the strongest predictor of reduced QoL (EQ-5D: beta = -0.095; GIQ …
QoL was assessed at multiple time points using generic (EQ-5D) and disease-specific (GIQLI) instruments. Demographics, imaging, and s …
Intracerebral hemorrhage location and outcome among INTERACT2 participants.
Delcourt C, Sato S, Zhang S, Sandset EC, Zheng D, Chen X, Hackett ML, Arima H, Hata J, Heeley E, Al-Shahi Salman R, Robinson T, Davies L, Lavados PM, Lindley RI, Stapf C, Chalmers J, Anderson CS; INTERACT2 Investigators. Delcourt C, et al. Neurology. 2017 Apr 11;88(15):1408-1414. doi: 10.1212/WNL.0000000000003771. Epub 2017 Feb 24. Neurology. 2017. PMID: 28235817 Free PMC article. Clinical Trial.
Involvement of the posterior limb of the internal capsule, thalamus, and infratentorial sites were each associated with poor EQ-5D utility score ( 0.7 [median]; OR 1.87, 2.14, and 2.81, respectively). Posterior limb of internal capsule involvement was strongly associated w …
Involvement of the posterior limb of the internal capsule, thalamus, and infratentorial sites were each associated with poor EQ-5D ut …
Dutch Nationwide Cohort Experience with a New PROMs Set in Metabolic and Bariatric Surgery: BODY-Q Obesity Module.
Nienhuijs SW, Bruinsma F, Schouten R, Hoogbergen MM, Cnossen NG, Gernette C, van Rossum EFC, de Vries CEE, Monpellier VM, Klassen AF, Pusic AL, Liem RSL; Dutch Audit for Treatment of Obesity Research Group. Nienhuijs SW, et al. Obes Surg. 2025 Jan;35(1):67-77. doi: 10.1007/s11695-024-07615-5. Epub 2024 Dec 26. Obes Surg. 2025. PMID: 39724423
MATERIALS AND METHODS: All Dutch patients undergoing bariatric surgery between 2019 and 2022 were selected. Completed questionnaires of RAND-36, EQ-5D-5L, and BODY-Q were reviewed with baseline and 1-year results. Uni- and multivariable regression analyses were performed t …
MATERIALS AND METHODS: All Dutch patients undergoing bariatric surgery between 2019 and 2022 were selected. Completed questionnaires of RAND …