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Matrix metalloproteinase inhibitor properties of tetracyclines: therapeutic potential in cardiovascular diseases.
Castro MM, Kandasamy AD, Youssef N, Schulz R. Castro MM, et al. Pharmacol Res. 2011 Dec;64(6):551-60. doi: 10.1016/j.phrs.2011.05.005. Epub 2011 May 31. Pharmacol Res. 2011. PMID: 21689755 Review.
Matrix metalloproteinase (MMP)-2 activation by oxidative stress decreases aortic calponin-1 levels during hypertrophic remodeling in early hypertension.
Blascke de Mello MM, Parente JM, Schulz R, Castro MM. Blascke de Mello MM, et al. Among authors: castro mm. Vascul Pharmacol. 2019 May;116:36-44. doi: 10.1016/j.vph.2018.10.002. Epub 2018 Oct 16. Vascul Pharmacol. 2019. PMID: 30339939
The potential of stimulating nitric oxide formation in the treatment of hypertension.
Pinheiro LC, Tanus-Santos JE, Castro MM. Pinheiro LC, et al. Among authors: castro mm. Expert Opin Ther Targets. 2017 May;21(5):543-556. doi: 10.1080/14728222.2017.1310840. Epub 2017 Mar 30. Expert Opin Ther Targets. 2017. PMID: 28338370 Review.
Matrix Metalloproteinase-2 Activity is Associated with Divergent Regulation of Calponin-1 in Conductance and Resistance Arteries in Hypertension-induced Early Vascular Dysfunction and Remodelling.
Parente JM, Pereira CA, Oliveira-Paula GH, Tanus-Santos JE, Tostes RC, Castro MM. Parente JM, et al. Among authors: castro mm. Basic Clin Pharmacol Toxicol. 2017 Oct;121(4):246-256. doi: 10.1111/bcpt.12787. Epub 2017 Jun 15. Basic Clin Pharmacol Toxicol. 2017. PMID: 28374979
Doxycycline reduces cardiac matrix metalloproteinase-2 activity but does not ameliorate myocardial dysfunction during reperfusion in coronary artery bypass patients undergoing cardiopulmonary bypass.
Schulze CJ, Castro MM, Kandasamy AD, Cena J, Bryden C, Wang SH, Koshal A, Tsuyuki RT, Finegan BA, Schulz R. Schulze CJ, et al. Among authors: castro mm. Crit Care Med. 2013 Nov;41(11):2512-20. doi: 10.1097/CCM.0b013e318292373c. Crit Care Med. 2013. PMID: 23928836 Clinical Trial.
Inhibition of matrix metalloproteinases (MMPs) as a potential strategy to ameliorate hypertension-induced cardiovascular alterations.
Castro MM, Tanus-Santos JE. Castro MM, et al. Curr Drug Targets. 2013 Mar;14(3):335-43. doi: 10.2174/1389450111314030005. Curr Drug Targets. 2013. PMID: 23316965 Review.
Matrix metalloproteinase-2 proteolysis of calponin-1 contributes to vascular hypocontractility in endotoxemic rats.
Castro MM, Cena J, Cho WJ, Walsh MP, Schulz R. Castro MM, et al. Arterioscler Thromb Vasc Biol. 2012 Mar;32(3):662-8. doi: 10.1161/ATVBAHA.111.242685. Epub 2011 Dec 22. Arterioscler Thromb Vasc Biol. 2012. PMID: 22199370
Matrix metalloproteinases: targets for doxycycline to prevent the vascular alterations of hypertension.
Castro MM, Tanus-Santos JE, Gerlach RF. Castro MM, et al. Pharmacol Res. 2011 Dec;64(6):567-72. doi: 10.1016/j.phrs.2011.04.002. Epub 2011 Apr 9. Pharmacol Res. 2011. PMID: 21514386 Review.
Remodeling of aorta extracellular matrix as a result of transient high oxygen exposure in newborn rats: implication for arterial rigidity and hypertension risk.
Huyard F, Yzydorczyk C, Castro MM, Cloutier A, Bertagnolli M, Sartelet H, Germain N, Comte B, Schulz R, DeBlois D, Nuyt AM. Huyard F, et al. Among authors: castro mm. PLoS One. 2014 Apr 17;9(4):e92287. doi: 10.1371/journal.pone.0092287. eCollection 2014. PLoS One. 2014. PMID: 24743169 Free PMC article.
Quercetin decreases the activity of matrix metalloproteinase-2 and ameliorates vascular remodeling in renovascular hypertension.
Pereira SC, Parente JM, Belo VA, Mendes AS, Gonzaga NA, do Vale GT, Ceron CS, Tanus-Santos JE, Tirapelli CR, Castro MM. Pereira SC, et al. Among authors: castro mm. Atherosclerosis. 2018 Mar;270:146-153. doi: 10.1016/j.atherosclerosis.2018.01.031. Epub 2018 Jan 31. Atherosclerosis. 2018. PMID: 29425960
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