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A safe and highly efficient tumor-targeted type I interferon immunotherapy depends on the tumor microenvironment.
Cauwels A, Van Lint S, Garcin G, Bultinck J, Paul F, Gerlo S, Van der Heyden J, Bordat Y, Catteeuw D, De Cauwer L, Rogge E, Verhee A, Uzé G, Tavernier J. Cauwels A, et al. Oncoimmunology. 2017 Nov 27;7(3):e1398876. doi: 10.1080/2162402X.2017.1398876. eCollection 2018. Oncoimmunology. 2017. PMID: 29399401 Free PMC article.
Simultaneous targeting of IL-1 and IL-18 is required for protection against inflammatory and septic shock.
Vanden Berghe T, Demon D, Bogaert P, Vandendriessche B, Goethals A, Depuydt B, Vuylsteke M, Roelandt R, Van Wonterghem E, Vandenbroecke J, Choi SM, Meyer E, Krautwald S, Declercq W, Takahashi N, Cauwels A, Vandenabeele P. Vanden Berghe T, et al. Among authors: Cauwels A. Am J Respir Crit Care Med. 2014 Feb 1;189(3):282-91. doi: 10.1164/rccm.201308-1535OC. Am J Respir Crit Care Med. 2014. PMID: 24456467
Delivering Type I Interferon to Dendritic Cells Empowers Tumor Eradication and Immune Combination Treatments.
Cauwels A, Van Lint S, Paul F, Garcin G, De Koker S, Van Parys A, Wueest T, Gerlo S, Van der Heyden J, Bordat Y, Catteeuw D, Rogge E, Verhee A, Vandekerckhove B, Kley N, Uzé G, Tavernier J. Cauwels A, et al. Cancer Res. 2018 Jan 15;78(2):463-474. doi: 10.1158/0008-5472.CAN-17-1980. Epub 2017 Nov 29. Cancer Res. 2018. PMID: 29187401 Free article.
Safe eradication of large established tumors using neovasculature-targeted tumor necrosis factor-based therapies.
Huyghe L, Van Parys A, Cauwels A, Van Lint S, De Munter S, Bultinck J, Zabeau L, Hostens J, Goethals A, Vanderroost N, Verhee A, Uzé G, Kley N, Peelman F, Vandekerckhove B, Brouckaert P, Tavernier J. Huyghe L, et al. Among authors: Cauwels A. EMBO Mol Med. 2020 Feb 7;12(2):e11223. doi: 10.15252/emmm.201911223. Epub 2020 Jan 8. EMBO Mol Med. 2020. PMID: 31912630 Free article.
TLR-2 and TLR-9 are sensors of apoptosis in a mouse model of doxorubicin-induced acute inflammation.
Krysko DV, Kaczmarek A, Krysko O, Heyndrickx L, Woznicki J, Bogaert P, Cauwels A, Takahashi N, Magez S, Bachert C, Vandenabeele P. Krysko DV, et al. Among authors: Cauwels A. Cell Death Differ. 2011 Aug;18(8):1316-25. doi: 10.1038/cdd.2011.4. Epub 2011 Feb 11. Cell Death Differ. 2011. PMID: 21311566 Free PMC article.
Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models.
Takahashi N, Duprez L, Grootjans S, Cauwels A, Nerinckx W, DuHadaway JB, Goossens V, Roelandt R, Van Hauwermeiren F, Libert C, Declercq W, Callewaert N, Prendergast GC, Degterev A, Yuan J, Vandenabeele P. Takahashi N, et al. Among authors: Cauwels A. Cell Death Dis. 2012 Nov 29;3(11):e437. doi: 10.1038/cddis.2012.176. Cell Death Dis. 2012. PMID: 23190609 Free PMC article.
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