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The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes.
McMahon M, Itoh K, Yamamoto M, Chanas SA, Henderson CJ, McLellan LI, Wolf CR, Cavin C, Hayes JD. McMahon M, et al. Cancer Res. 2001 Apr 15;61(8):3299-307. Cancer Res. 2001. PMID: 11309284
Both Nrf2-/- and Nrf2+/+ mice were fed a control diet or one supplemented with either synthetic cancer chemopreventive agents [butylated hydroxyanisole (BHA), ethoxyquin (EQ), or oltipraz] or phytochemicals [indole-3-carbinol, cafestol and kahweol palmitate, …
Both Nrf2-/- and Nrf2+/+ mice were fed a control diet or one supplemented with either synthetic cancer chemopreventive agents [butyla …
Protective effects of coffee diterpenes against aflatoxin B1-induced genotoxicity: mechanisms in rat and human cells.
Cavin C, Mace K, Offord EA, Schilter B. Cavin C, et al. Food Chem Toxicol. 2001 Jun;39(6):549-56. doi: 10.1016/s0278-6915(00)00168-x. Food Chem Toxicol. 2001. PMID: 11346484
The coffee-specific diterpenes cafestol and kahweol (C + K) have been reported to be anticarcinogenic in several animal models. Proposed mechanisms involve a co-ordinated modulation of several enzymes responsible for carcinogen detoxification, thus preventing …
The coffee-specific diterpenes cafestol and kahweol (C + K) have been reported to be anticarcinogenic in several animal …
Cafestol and kahweol, two coffee specific diterpenes with anticarcinogenic activity.
Cavin C, Holzhaeuser D, Scharf G, Constable A, Huber WW, Schilter B. Cavin C, et al. Food Chem Toxicol. 2002 Aug;40(8):1155-63. doi: 10.1016/s0278-6915(02)00029-7. Food Chem Toxicol. 2002. PMID: 12067578 Review.
In animal models and cell culture systems, the coffee diterpenes cafestol and kahweol (C+K) were shown to produce a broad range of biochemical effects resulting in a reduction of the genotoxicity of several carcinogens including 7,12-dimethylbenz[a]anthracene (DMBA) …
In animal models and cell culture systems, the coffee diterpenes cafestol and kahweol (C+K) were shown to produce a broad rang …
Induction of cancer chemopreventive enzymes by coffee is mediated by transcription factor Nrf2. Evidence that the coffee-specific diterpenes cafestol and kahweol confer protection against acrolein.
Higgins LG, Cavin C, Itoh K, Yamamoto M, Hayes JD. Higgins LG, et al. Toxicol Appl Pharmacol. 2008 Feb 1;226(3):328-37. doi: 10.1016/j.taap.2007.09.018. Epub 2007 Sep 26. Toxicol Appl Pharmacol. 2008. PMID: 18028974
Treatment of mouse embryonic fibroblasts (MEFs) from nrf2(+/+) mice with either coffee or the coffee-specific diterpenes cafestol and kahweol (C+K) increased NQO1 mRNA up to 9-fold. MEFs from nrf2(-/-) mice expressed less NQO1 mRNA than did wild-type MEFs, but NQO1 …
Treatment of mouse embryonic fibroblasts (MEFs) from nrf2(+/+) mice with either coffee or the coffee-specific diterpenes cafestol and …
Placental glutathione S-transferase (GST-P) induction as a potential mechanism for the anti-carcinogenic effect of the coffee-specific components cafestol and kahweol.
Schilter B, Perrin I, Cavin C, Huggett AC. Schilter B, et al. Carcinogenesis. 1996 Nov;17(11):2377-84. doi: 10.1093/carcin/17.11.2377. Carcinogenesis. 1996. PMID: 8968051
The coffee specific diterpenes cafestol and kahweol (C + K) have been reported to be anti-carcinogenic in several animal models. ...There was no indication of the presence of preneoplastic foci and, furthermore, the effect of C + K on the GST-P was completely revers …
The coffee specific diterpenes cafestol and kahweol (C + K) have been reported to be anti-carcinogenic in several animal model …