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Metalloproteinase inhibitors and the prevention of connective tissue breakdown.
Cawston TE. Cawston TE. Pharmacol Ther. 1996;70(3):163-82. doi: 10.1016/0163-7258(96)00015-0. Pharmacol Ther. 1996. PMID: 8888065 Review.
The role of soluble interleukin (IL)-6 receptor in mediating the effects of IL-6 on matrix metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 expression by gingival fibroblasts.
Irwin CR, Myrillas TT, Traynor P, Leadbetter N, Cawston TE. Irwin CR, et al. Among authors: cawston te. J Periodontol. 2002 Jul;73(7):741-7. doi: 10.1902/jop.2002.73.7.741. J Periodontol. 2002. PMID: 12146533
Histone deacetylase inhibitors modulate metalloproteinase gene expression in chondrocytes and block cartilage resorption.
Young DA, Lakey RL, Pennington CJ, Jones D, Kevorkian L, Edwards DR, Cawston TE, Clark IM. Young DA, et al. Among authors: cawston te. Arthritis Res Ther. 2005;7(3):R503-12. doi: 10.1186/ar1702. Epub 2005 Feb 22. Arthritis Res Ther. 2005. PMID: 15899037 Free PMC article.
Cytokine synergy, collagenases and cartilage collagen breakdown.
Cawston TE, Milner JM, Catterall JB, Rowan AD. Cawston TE, et al. Biochem Soc Symp. 2003;(70):125-33. doi: 10.1042/bss0700125. Biochem Soc Symp. 2003. PMID: 14587288 Review.
Lipophilic statins prevent matrix metalloproteinase-mediated cartilage collagen breakdown by inhibiting protein geranylgeranylation.
Barter MJ, Hui W, Lakey RL, Catterall JB, Cawston TE, Young DA. Barter MJ, et al. Among authors: cawston te. Ann Rheum Dis. 2010 Dec;69(12):2189-98. doi: 10.1136/ard.2010.129197. Epub 2010 Aug 6. Ann Rheum Dis. 2010. PMID: 20693272
Proteinases involved in matrix turnover during cartilage and bone breakdown.
Cawston TE, Young DA. Cawston TE, et al. Cell Tissue Res. 2010 Jan;339(1):221-35. doi: 10.1007/s00441-009-0887-6. Epub 2009 Nov 14. Cell Tissue Res. 2010. PMID: 19915869 Review.
Matrix metalloproteinase knockout studies and the potential use of matrix metalloproteinase inhibitors in the rheumatic diseases.
Milner JM, Cawston TE. Milner JM, et al. Among authors: cawston te. Curr Drug Targets Inflamm Allergy. 2005 Jun;4(3):363-75. doi: 10.2174/1568010054022141. Curr Drug Targets Inflamm Allergy. 2005. PMID: 16101546 Review.
Adenoviral gene transfer of interleukin-1 in combination with oncostatin M induces significant joint damage in a murine model.
Rowan AD, Hui W, Cawston TE, Richards CD. Rowan AD, et al. Among authors: cawston te. Am J Pathol. 2003 Jun;162(6):1975-84. doi: 10.1016/S0002-9440(10)64330-1. Am J Pathol. 2003. PMID: 12759253 Free PMC article.
Drugs in development: bisphosphonates and metalloproteinase inhibitors.
Catterall JB, Cawston TE. Catterall JB, et al. Among authors: cawston te. Arthritis Res Ther. 2003;5(1):12-24. doi: 10.1186/ar604. Epub 2002 Nov 8. Arthritis Res Ther. 2003. PMID: 12716443 Free PMC article. Review.
Mechanisms of induction of human tissue inhibitor of metalloproteinases-1 (TIMP-1) gene expression by all-trans retinoic acid in combination with basic fibroblast growth factor.
Bigg HF, McLeod R, Waters JG, Cawston TE, Clark IM. Bigg HF, et al. Among authors: cawston te. Eur J Biochem. 2000 Jul;267(13):4150-6. doi: 10.1046/j.1432-1327.2000.01459.x. Eur J Biochem. 2000. PMID: 10866818
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