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Identification of human liver cytochrome P450s involved in the microsomal metabolism of the antihistaminic drug loratadine.
Yumibe N, Huie K, Chen KJ, Clement RP, Cayen MN. Yumibe N, et al. Among authors: cayen mn. Int Arch Allergy Immunol. 1995 May-Jun;107(1-3):420. doi: 10.1159/000237063. Int Arch Allergy Immunol. 1995. PMID: 7613198 No abstract available.
Effect of race and sex on single and multiple dose pharmacokinetics of desloratadine.
Affrime M, Banfield C, Gupta S, Cohen A, Boutros T, Thonoor M, Cayen M. Affrime M, et al. Clin Pharmacokinet. 2002;41 Suppl 1:21-8. doi: 10.2165/00003088-200241001-00004. Clin Pharmacokinet. 2002. PMID: 12169043 Clinical Trial.
Desloratadine demonstrates dose proportionality in healthy adults after single doses.
Gupta S, Banfield C, Affrime M, Marco A, Cayen M, Herron J, Padhi D. Gupta S, et al. Clin Pharmacokinet. 2002;41 Suppl 1:1-6. doi: 10.2165/00003088-200241001-00001. Clin Pharmacokinet. 2002. PMID: 12169040 Clinical Trial.
Pharmacokinetics of Loratadine in Pediatric Subjects.
Lin CC, Radwanski E, Affrime M, Cayen M. Lin CC, et al. Am J Ther. 1995 Jul;2(7):504-508. doi: 10.1097/00045391-199506000-00011. Am J Ther. 1995. PMID: 11850699
Pharmacokinetics and metabolism of genaconazole, a potent antifungal drug, in men.
Lin C, Kim H, Radwanski E, Affrime M, Brannan M, Cayen MN. Lin C, et al. Among authors: cayen mn. Antimicrob Agents Chemother. 1996 Jan;40(1):92-6. doi: 10.1128/AAC.40.1.92. Antimicrob Agents Chemother. 1996. PMID: 8787886 Free PMC article. Clinical Trial.
Pharmacokinetics and metabolism of 14C-isepamicin in humans following intravenous administration.
Lin C, Korduba C, Affrime M, Radwanski E, Nomeir A, Batra V, Cutler D, Cayen MN. Lin C, et al. Among authors: cayen mn. Antimicrob Agents Chemother. 1995 Oct;39(10):2201-3. doi: 10.1128/aac.39.10.2201. Antimicrob Agents Chemother. 1995. PMID: 8619567 Free PMC article.
Influence of food on the oral bioavailability of loratadine and pseudoephedrine from extended-release tablets in healthy volunteers.
Nomeir AA, Mojaverian P, Kosoglou T, Affrime MB, Nezamis J, Rodwanski E, Lin CC, Cayen MN. Nomeir AA, et al. Among authors: cayen mn. J Clin Pharmacol. 1996 Oct;36(10):923-30. doi: 10.1002/j.1552-4604.1996.tb04759.x. J Clin Pharmacol. 1996. PMID: 8930779
Identification of human liver cytochrome P450 enzymes that metabolize the nonsedating antihistamine loratadine. Formation of descarboethoxyloratadine by CYP3A4 and CYP2D6.
Yumibe N, Huie K, Chen KJ, Snow M, Clement RP, Cayen MN. Yumibe N, et al. Among authors: cayen mn. Biochem Pharmacol. 1996 Jan 26;51(2):165-72. doi: 10.1016/0006-2952(95)02169-8. Biochem Pharmacol. 1996. PMID: 8615885
Evaluation of loratadine as an inducer of liver microsomal cytochrome P450 in rats and mice.
Parkinson A, Clement RP, Casciano CN, Cayen MN. Parkinson A, et al. Among authors: cayen mn. Biochem Pharmacol. 1992 May 28;43(10):2169-80. doi: 10.1016/0006-2952(92)90176-j. Biochem Pharmacol. 1992. PMID: 1534660
Loratadine administered concomitantly with erythromycin: pharmacokinetic and electrocardiographic evaluations.
Brannan MD, Reidenberg P, Radwanski E, Shneyer L, Lin CC, Cayen MN, Affrime MB. Brannan MD, et al. Among authors: cayen mn. Clin Pharmacol Ther. 1995 Sep;58(3):269-78. doi: 10.1016/0009-9236(95)90243-0. Clin Pharmacol Ther. 1995. PMID: 7554700 Clinical Trial.
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