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282 results

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Page 1
The CD200-CD200R1 inhibitory signaling pathway: immune regulation and host-pathogen interactions.
Vaine CA, Soberman RJ. Vaine CA, et al. Adv Immunol. 2014;121:191-211. doi: 10.1016/B978-0-12-800100-4.00005-2. Adv Immunol. 2014. PMID: 24388216 Free PMC article. Review.
The CD200:CD200R1 inhibitory signaling pathway has been implicated in playing a prominent role in limiting inflammation in a wide range of inflammatory diseases. ...A complete understanding of the pathways regulated by CD200R1 signaling and the diverse mechanisms th …
The CD200:CD200R1 inhibitory signaling pathway has been implicated in playing a prominent role in limiting inflammation in a wide ran …
CD200-CD200R1 signaling pathway regulates neuroinflammation after stroke.
Zhao SC, Heng X, Ya-Ping W, Di L, Wen-Qian W, Ling-Song M, Chu ZH, Xu Y. Zhao SC, et al. Brain Behav. 2020 Dec;10(12):e01882. doi: 10.1002/brb3.1882. Epub 2020 Oct 17. Brain Behav. 2020. PMID: 33067924 Free PMC article.
To study the relationship between CD200/CD200R1 expression and the diversity of the neuroinflammatory response in stroke, CD200Fc (CD200R1 agonist) was subcutaneously injected at onset, at 1 day and 2 days after MCAO operation, and the brains were collected for dete …
To study the relationship between CD200/CD200R1 expression and the diversity of the neuroinflammatory response in stroke, CD200Fc ( …
CD200R1 Contributes to Successful Functional Reinnervation after a Sciatic Nerve Injury.
Pannunzio B, Amo-Aparicio J, Julián C, López-Vales R, Peluffo H, Lago N. Pannunzio B, et al. Cells. 2022 May 30;11(11):1786. doi: 10.3390/cells11111786. Cells. 2022. PMID: 35681481 Free PMC article.
The role of CD200R1 in Wallerian Degeneration (WD) and nerve regeneration was studied using a specific antibody against CD200R1 injected into the nerve at the time of injury. We found an upregulation of CD200R1 mRNA after injury whereas CD200 was downregulate …
The role of CD200R1 in Wallerian Degeneration (WD) and nerve regeneration was studied using a specific antibody against CD200R1
CD200R1 regulates eosinophilia during pulmonary fungal infection in mice.
Salek-Ardakani S, Bell T, Jagger CP, Snelgrove RJ, Hussell T. Salek-Ardakani S, et al. Eur J Immunol. 2019 Sep;49(9):1380-1390. doi: 10.1002/eji.201847861. Epub 2019 Aug 7. Eur J Immunol. 2019. PMID: 31365119 Free PMC article.
By contrast, we demonstrate that, rather than promoting type I cytokine responses, CD200R1 blockade enhanced eosinophilia in a mouse model of Cryptococcus neoformans infection, whereas CD200R1 agonism reduced lung eosinophilia - with neither strategy completely alte …
By contrast, we demonstrate that, rather than promoting type I cytokine responses, CD200R1 blockade enhanced eosinophilia in a mouse …
Activation of the CD200/CD200R1 axis attenuates neuroinflammation and improves postoperative cognitive dysfunction via the PI3K/Akt/NF-kappaB signaling pathway in aged mice.
Qian H, Gao F, Wu X, Lin D, Huang Y, Chen A, Deng J, Gong C, Chen X, Zheng X. Qian H, et al. Inflamm Res. 2023 Dec;72(12):2127-2144. doi: 10.1007/s00011-023-01804-1. Epub 2023 Oct 30. Inflamm Res. 2023. PMID: 37902837
The aim of this study was to investigate the impact and underlying mechanism of CD200/CD200R1 axis on POCD in aged mice. METHODS: The model of POCD was established in aged mice. To assess the learning and memory abilities of model mice, the Morris water maze test was imple …
The aim of this study was to investigate the impact and underlying mechanism of CD200/CD200R1 axis on POCD in aged mice. METHODS: The …
The regulation of NFKB1 on CD200R1 expression and their potential roles in Parkinson's disease.
Lin S, Shu Y, Shen R, Zhou Y, Pan H, He L, Fang F, Zhu X, Wang X, Wang Y, Xu W, Ding J. Lin S, et al. J Neuroinflammation. 2024 Sep 18;21(1):229. doi: 10.1186/s12974-024-03231-3. J Neuroinflammation. 2024. PMID: 39294682 Free PMC article.
Knocking-down or overexpressing NFKB1 validated its regulatory effect on CD200R1. Correlation between decreased CD200R1 and deficient NFKB1 was studied using Genotype-Tissue Expression database. ...Significant correlation between NFKB1 and CD200R1 expression …
Knocking-down or overexpressing NFKB1 validated its regulatory effect on CD200R1. Correlation between decreased CD200R1 and de …
CD200R1 promotes interleukin-17 production by group 3 innate lymphoid cells by enhancing signal transducer and activator of transcription 3 activation.
Linley H, Ogden A, Jaigirdar S, Buckingham L, Cox J, Priestley M, Saunders A. Linley H, et al. Mucosal Immunol. 2023 Apr;16(2):167-179. doi: 10.1016/j.mucimm.2023.01.001. Epub 2023 Jan 7. Mucosal Immunol. 2023. PMID: 36623588 Free PMC article.
CD200R1 is also highly expressed on ILCs, where its function remains largely unexplored. We previously observed reduced CD200R1 signaling in psoriasis-affected skin, suggesting that dysregulation may promote disease. ...
CD200R1 is also highly expressed on ILCs, where its function remains largely unexplored. We previously observed reduced CD200R1
Reduced cutaneous CD200:CD200R1 signaling in psoriasis enhances neutrophil recruitment to skin.
Linley H, Jaigirdar S, Mohamed K, Griffiths CEM, Saunders A. Linley H, et al. Immun Inflamm Dis. 2022 Jul;10(7):e648. doi: 10.1002/iid3.648. Immun Inflamm Dis. 2022. PMID: 35759230 Free PMC article.
METHODS: Human skin biopsies were examined by quantitative polymerase chain reaction, flow cytometry, and immunohistochemistry. The role of CD200R1 in regulating psoriasis-like skin inflammation was examined using CD200R1 blocking antibodies in mouse psoriasis model …
METHODS: Human skin biopsies were examined by quantitative polymerase chain reaction, flow cytometry, and immunohistochemistry. The role of …
Activation of the CD200/CD200R1 axis improves cognitive impairment by enhancing hippocampal neurogenesis via suppression of M1 microglial polarization and neuroinflammation in hypoxic-ischemic neonatal rats.
Qian H, Chen A, Lin D, Deng J, Gao F, Wei J, Wu X, Huang Y, Cai D, Chen X, Zheng X. Qian H, et al. Int Immunopharmacol. 2024 Feb 15;128:111532. doi: 10.1016/j.intimp.2024.111532. Epub 2024 Jan 18. Int Immunopharmacol. 2024. PMID: 38237226 Free article.
This study aimed to evaluate the role of the cluster of differentiation 200 (CD200)/CD200R1 axis in cognitive function following HIBD using an established model of HIBD in postnatal day 7 rats. ...In contrast, blocking the interaction between CD200 and CD200R1 with …
This study aimed to evaluate the role of the cluster of differentiation 200 (CD200)/CD200R1 axis in cognitive function following HIBD …
282 results