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1976 3
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1979 1
1987 1
1989 1
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Page 1
Cefazaflur, a new parenteral cephalosporin: in vitro studies.
Counts GW, Gregory D, Zeleznik D, Turch M. Counts GW, et al. Antimicrob Agents Chemother. 1977 Apr;11(4):708-11. doi: 10.1128/AAC.11.4.708. Antimicrob Agents Chemother. 1977. PMID: 324399 Free PMC article.
Cefazaflur was tested in vitro against 262 strains of bacteria. Inhibitory and bactericidal concentrations were determined with two inoculum sizes of bacterial cells in Mueller-Hinton broth and nutrient broth. ...The drug demonstrated less activity in broth than in agar, a …
Cefazaflur was tested in vitro against 262 strains of bacteria. Inhibitory and bactericidal concentrations were determined with two i …
Cefazaflur: kinetics of hydrolysis in aqueous solution, acid dissociation constant and alkaline decomposition to fluorescent products.
Irwin VP, Timoney RF. Irwin VP, et al. J Pharm Pharmacol. 1989 May;41(5):360. doi: 10.1111/j.2042-7158.1989.tb06477.x. J Pharm Pharmacol. 1989. PMID: 2569531
The values of the pseudo-first order hydrolysis rate constants in the pH range 1 to 10, and the pKa, were determined for cefazaflur in aqueous solution at 37 degrees C and ionic strength 0.2 M. ...
The values of the pseudo-first order hydrolysis rate constants in the pH range 1 to 10, and the pKa, were determined for cefazaflur i …
Pharmacokinetic properties of the cephalosporins.
Bergan T. Bergan T. Drugs. 1987;34 Suppl 2:89-104. doi: 10.2165/00003495-198700342-00008. Drugs. 1987. PMID: 3319507 Review.
Among agents that are absorbed from the gastrointestinal tract, those with bioavailabilities of 85 to 90% include cefroxadine, cefadroxil, cefsumide, cephalexin, cephradine, cephacetrile, and cefazaflur. Most cephalosporins are eliminated rapidly, with serum half-lives (t1 …
Among agents that are absorbed from the gastrointestinal tract, those with bioavailabilities of 85 to 90% include cefroxadine, cefadroxil, c …
In vitro studies with cefazaflur and other parenteral cephalosporins.
Actor P, Guarini JR, Uri J, Bartus HF, Zajac I, Weisbach JA. Actor P, et al. J Antibiot (Tokyo). 1977 Sep;30(9):730-5. doi: 10.7164/antibiotics.30.730. J Antibiot (Tokyo). 1977. PMID: 924896 Free article.
Cefazaflur has a broad-spectrum of in vitro antibacterial activity equal to or greater than that of the commercially-available cephalosporins. ...Human serum had a relatively small effect on the in vitro activity of cefazaflur....
Cefazaflur has a broad-spectrum of in vitro antibacterial activity equal to or greater than that of the commercially-available cephal …
Pharmacokinetic study of cefazaflur compared to cephalothin and cefazolin.
Harvengt C, Muenier H, Lamy F. Harvengt C, et al. J Clin Pharmacol. 1977 Feb-Mar;17(2-3):128-33. doi: 10.1002/j.1552-4604.1977.tb04599.x. J Clin Pharmacol. 1977. PMID: 833342
A single 1-Gm dose of cefazaflur, a new semisynthetic cephalosporin derivative, was compared in a crossover study to the same dose of cephalothin and cefazolin by intramuscular injection in seven healthy volunteers. ...Local reactions at the site of intramuscular injection …
A single 1-Gm dose of cefazaflur, a new semisynthetic cephalosporin derivative, was compared in a crossover study to the same dose of …
Semiautomated turbidimetric microbiological assay for cefazaflur.
Pitkin DH, Actor P, Baldinus JG, Post A, Weisbach JA. Pitkin DH, et al. J Antibiot (Tokyo). 1978 Apr;31(4):359-62. doi: 10.7164/antibiotics.31.359. J Antibiot (Tokyo). 1978. PMID: 26651 Free article.
A quantitative semi-automated turbidimetric bioassay for cefazaflur, using Streptococcus faecium as the indicator, is described. Assays were run at pH 6.5 approximately 7 for 3.75 hours at 37 degrees C using 2 approximately 12 microgram cefazaflur per ml assay broth …
A quantitative semi-automated turbidimetric bioassay for cefazaflur, using Streptococcus faecium as the indicator, is described. Assa …
In vitro activity and beta-lactamase stability of cefazaflur compared with those of beta-lactamase-stable cephalosporins.
Aswapokee N, Neu HC. Aswapokee N, et al. Antimicrob Agents Chemother. 1979 Mar;15(3):444-6. doi: 10.1128/AAC.15.3.444. Antimicrob Agents Chemother. 1979. PMID: 313753 Free PMC article.
The in vitro activity of cefazaflur, a parenteral cephalosporin, was determined against 590 clinical isolates. Cefazaflur inhibited the majority of gram-positive cocci at concentrations below 1 mug/ml except for enterococci. ...
The in vitro activity of cefazaflur, a parenteral cephalosporin, was determined against 590 clinical isolates. Cefazaflur inhi …
Comparison of the antibacterial activity of nine cephalosporins against Enterobacteriaceae and nonfermentative gram-negative bacilli.
Verbist L. Verbist L. Antimicrob Agents Chemother. 1976 Oct;10(4):657-63. doi: 10.1128/AAC.10.4.657. Antimicrob Agents Chemother. 1976. PMID: 984801 Free PMC article.
The in vitro antibacterial activity of nine cephalosporins (cephalothin, cephaloridine, cephalexin, cefazolin, cefamandole, cefuroxime, cefatrizine, cefoxitin, and cefazaflur) was determined against 344 strains of Enterobacteriaceae and 99 nonfermentative gram-negative bac …
The in vitro antibacterial activity of nine cephalosporins (cephalothin, cephaloridine, cephalexin, cefazolin, cefamandole, cefuroxime, cefa …
Use of a heavy inoculum in the in vitro evaluation of the anti-staphylococcal activity of 19 cephalosporins.
Laverdiere M, Welter D, Sabath LD. Laverdiere M, et al. Antimicrob Agents Chemother. 1978 Apr;13(4):669-75. doi: 10.1128/AAC.13.4.669. Antimicrob Agents Chemother. 1978. PMID: 352261 Free PMC article.
The activity of most of the other compounds was also decreased with the use of a heavy inoculum, but this was observed only with selected isolates. Cephapirin, cephalothin, and cefazaflur were the most active drugs against the methicillin-susceptible isolates. Cephaloridin …
The activity of most of the other compounds was also decreased with the use of a heavy inoculum, but this was observed only with selected is …
12 results