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CELA1 Mediates Progressive Emphysema in Alpha-1 Antitrypsin Deficiency.
Devine AJ, Smith NJ, Joshi R, Fan Q, Borchers MT, Clair GC, Adkins JN, Varisco BM. Devine AJ, et al. Res Sq [Preprint]. 2023 Feb 23:rs.3.rs-2617812. doi: 10.21203/rs.3.rs-2617812/v1. Res Sq. 2023. PMID: 36865303 Free PMC article. Updated. Preprint.
In the LD-PPE model, AAT (-/-) mice developed progressive emphysema from which Cela1 (-/-) &AAT (-/-) mice were protected. In the CS model, Cela1 (-/-) &AAT (-/-) mice had worse emphysema than AAT (-/-) , and in the aging model, 72-75 week-old Cela1 ( …
In the LD-PPE model, AAT (-/-) mice developed progressive emphysema from which Cela1 (-/-) &AAT (-/-) mice were protected. In the …
Role for Cela1 in Postnatal Lung Remodeling and Alpha-1 Antitrypsin-Deficient Emphysema.
Joshi R, Heinz A, Fan Q, Guo S, Monia B, Schmelzer CEH, Weiss AS, Batie M, Parameshwaran H, Varisco BM. Joshi R, et al. Am J Respir Cell Mol Biol. 2018 Aug;59(2):167-178. doi: 10.1165/rcmb.2017-0361OC. Am J Respir Cell Mol Biol. 2018. PMID: 29420065 Free PMC article.
By mass spectrometry, Cela1 degraded mature elastin similarly to pancreatic elastase. Cela1 promoter and protein sequences were phylogenetically distinct in the placental mammal lineage, suggesting an adaptive role for lung-expressed Cela1 in this clade. A 6- …
By mass spectrometry, Cela1 degraded mature elastin similarly to pancreatic elastase. Cela1 promoter and protein sequences wer …
Anti-CELA1 antibody KF4 prevents emphysema by inhibiting stretch-mediated remodeling.
Ojha M, Smith NJ, Devine AJ, Joshi R, Goodman EM, Fan Q, Schuman R, Porollo A, Wells JM, Tiwary E, Batie MR, Gray J, Deshmukh H, Borchers MT, Ammerman SA, Varisco BM. Ojha M, et al. JCI Insight. 2024 Jan 9;9(1):e169189. doi: 10.1172/jci.insight.169189. JCI Insight. 2024. PMID: 38193533 Free PMC article.
This study tested whether CELA1 is important in strain-mediated lung matrix destruction in non-AAT-deficient emphysema and the efficacy of CELA1 neutralization. ...A CELA1-neutralizing antibody was developed (KF4), and it inhibited stretch-inducible lung elas …
This study tested whether CELA1 is important in strain-mediated lung matrix destruction in non-AAT-deficient emphysema and the effica …
mbtD and celA1 association with ethambutol resistance in Mycobacterium tuberculosis: A multiomics analysis.
Wu Z, Tan Q, Zhang C, Zhao Y, Liao Q, Yu M, Xu L, Wang J, Liang H, Li H, Chen L, Chen X, Wei W. Wu Z, et al. Front Cell Infect Microbiol. 2022 Aug 31;12:959911. doi: 10.3389/fcimb.2022.959911. eCollection 2022. Front Cell Infect Microbiol. 2022. PMID: 36118032 Free PMC article.
Correlation analysis revealed that the differential methylation of genes was negatively correlated with transcription levels in EMB-resistant strains. Additionally, two hypermethylated candidate genes (mbtD and celA1) were screened by iTRAQ-based quantitative proteomics an …
Correlation analysis revealed that the differential methylation of genes was negatively correlated with transcription levels in EMB-resistan …
Overexpression of the celA1 gene in BCG modifies surface pellicle, glucosamine content in biofilms, and affects in vivo replication.
Vaca-González A, Flores-Valdez MA, Aceves-Sánchez MJ, Camacho-Villegas TA, Pérez-Padilla NA, Burciaga-Flores M, De la Cruz MÁ, Ares MA, Mora-Montes HM, Bravo-Madrigal J, Gaona-Bernal J, Tamez-Castrellón AK. Vaca-González A, et al. Tuberculosis (Edinb). 2020 Dec;125:102005. doi: 10.1016/j.tube.2020.102005. Epub 2020 Oct 1. Tuberculosis (Edinb). 2020. PMID: 33032092
In this work, the celA1 gene of M. tuberculosis was cloned into the integrative pMV361 plasmid and then transformed into M. bovis BCG Pasteur to produce BCG:celA1, to have celA1 expressed from the strong promoter hsp60. ...In biofilms, we observed a significa …
In this work, the celA1 gene of M. tuberculosis was cloned into the integrative pMV361 plasmid and then transformed into M. bovis BCG …
Balkan nephropathy.
Stefanovic V, Toncheva D, Polenakovic M. Stefanovic V, et al. Clin Nephrol. 2015;83(7 Suppl 1):64-9. doi: 10.5414/cnp83s064. Clin Nephrol. 2015. PMID: 25725245 Free article. Review.
Exome sequencing of 22,000 genes revealed that mutant genes (CELA1, HSPG2, and KCNK5) in BN patients encode proteins involved in basement membrane/extracellular matrix and vascular tone, which are tightly connected to the process of angiogenesis. ...
Exome sequencing of 22,000 genes revealed that mutant genes (CELA1, HSPG2, and KCNK5) in BN patients encode proteins involved in base …
Chymotrypsin-like Elastase-1 Mediates Progressive Emphysema in Alpha-1 Antitrypsin Deficiency.
Devine AJ, Smith NJ, Joshi R, Fan Q, Borchers MT, Clair GC, Adkins JN, Varisco BM. Devine AJ, et al. Chronic Obstr Pulm Dis. 2023 Oct 26;10(4):380-391. doi: 10.15326/jcopdf.2023.0416. Chronic Obstr Pulm Dis. 2023. PMID: 37534975 Free PMC article.
Cela1(-/-)&AAT-deficient mice had less age-related airspace simplification than AAT-deficient and were comparable to wild type. While CELA1 promotes inflammation-independent emphysema progression and its absence preserves the lung matrix in multiple models of AA …
Cela1(-/-)&AAT-deficient mice had less age-related airspace simplification than AAT-deficient and were comparable to wild type. W …
NGS nominated CELA1, HSPG2, and KCNK5 as candidate genes for predisposition to Balkan endemic nephropathy.
Toncheva D, Mihailova-Hristova M, Vazharova R, Staneva R, Karachanak S, Dimitrov P, Simeonov V, Ivanov S, Balabanski L, Serbezov D, Malinov M, Stefanovic V, Čukuranović R, Polenakovic M, Jankovic-Velickovic L, Djordjevic V, Jevtovic-Stoimenov T, Plaseska-Karanfilska D, Galabov A, Djonov V, Dimova I. Toncheva D, et al. Biomed Res Int. 2014;2014:920723. doi: 10.1155/2014/920723. Epub 2014 May 15. Biomed Res Int. 2014. PMID: 24949484 Free PMC article.
From nonannotated variants with more than 40% frequency in both patients' groups, we nominated 3 genes with possible deleterious/damaging variants--CELA1, HSPG2, and KCNK5. Mutant genes (CELA1, HSPG2, and KCNK5) in BEN patients encode proteins involved in basement m …
From nonannotated variants with more than 40% frequency in both patients' groups, we nominated 3 genes with possible deleterious/damaging va …
Stretch regulates expression and binding of chymotrypsin-like elastase 1 in the postnatal lung.
Joshi R, Liu S, Brown MD, Young SM, Batie M, Kofron JM, Xu Y, Weaver TE, Apsley K, Varisco BM. Joshi R, et al. FASEB J. 2016 Feb;30(2):590-600. doi: 10.1096/fj.15-277350. Epub 2015 Oct 6. FASEB J. 2016. PMID: 26443822 Free PMC article.
We sought to determine whether stretch regulates Cela1 expression and Cela1 binding to lung elastin. In C57BL/6J mice, Cela1 protein increased 176-fold during lung morphogenesis. ...Post-PNX, Cela1 mRNA increased 6-fold, protein 3-fold, and Cela1 …
We sought to determine whether stretch regulates Cela1 expression and Cela1 binding to lung elastin. In C57BL/6J mice, Cela …
Cloning and nucleotide sequence of celA1, and endo-beta-1,4-glucanase-encoding gene from Streptomyces halstedii JM8.
Fernández-Abalos JM, Sánchez P, Coll PM, Villanueva JR, Pérez P, Santamaría RI. Fernández-Abalos JM, et al. J Bacteriol. 1992 Oct;174(20):6368-76. doi: 10.1128/jb.174.20.6368-6376.1992. J Bacteriol. 1992. PMID: 1400190 Free PMC article.
The celA1 gene encoding an endo-beta-1,4-glucanase from a mesophilic actinomycete, strain JM8, identified as Streptomyces halstedii, was cloned and expressed in S. lividans JI66. ...This sequence has been implicated in the mechanism of induction exerted by cellobiose. Usin …
The celA1 gene encoding an endo-beta-1,4-glucanase from a mesophilic actinomycete, strain JM8, identified as Streptomyces halstedii, …
48 results