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The first two blastomeres contribute unequally to the human embryo.
Junyent S, Meglicki M, Vetter R, Mandelbaum R, King C, Patel EM, Iwamoto-Stohl L, Reynell C, Chen DY, Rubino P, Arrach N, Paulson RJ, Iber D, Zernicka-Goetz M. Junyent S, et al. Cell. 2024 May 23;187(11):2838-2854.e17. doi: 10.1016/j.cell.2024.04.029. Epub 2024 May 13. Cell. 2024. PMID: 38744282 Free article.
Vertebrate centromeres in mitosis are functionally bipartite structures stabilized by cohesin.
Sacristan C, Samejima K, Ruiz LA, Deb M, Lambers MLA, Buckle A, Brackley CA, Robertson D, Hori T, Webb S, Kiewisz R, Bepler T, van Kwawegen E, Risteski P, Vukušić K, Tolić IM, Müller-Reichert T, Fukagawa T, Gilbert N, Marenduzzo D, Earnshaw WC, Kops GJPL. Sacristan C, et al. Cell. 2024 May 13:S0092-8674(24)00409-4. doi: 10.1016/j.cell.2024.04.014. Online ahead of print. Cell. 2024. PMID: 38744280 Free article.
Osr2 functions as a biomechanical checkpoint to aggravate CD8+ T cell exhaustion in tumor.
Zhang J, Li J, Hou Y, Lin Y, Zhao H, Shi Y, Chen K, Nian C, Tang J, Pan L, Xing Y, Gao H, Yang B, Song Z, Cheng Y, Liu Y, Sun M, Linghu Y, Li J, Huang H, Lai Z, Zhou Z, Li Z, Sun X, Chen Q, Su D, Li W, Peng Z, Liu P, Chen W, Huang H, Chen Y, Xiao B, Ye L, Chen L, Zhou D. Zhang J, et al. Cell. 2024 May 9:S0092-8674(24)00448-3. doi: 10.1016/j.cell.2024.04.023. Online ahead of print. Cell. 2024. PMID: 38744281