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LAG-3 and PD-1 synergize on CD8+ T cells to drive T cell exhaustion and hinder autocrine IFN-γ-dependent anti-tumor immunity.
Cell. 2024 Aug 8;187(16):4355-4372.e22. doi: 10.1016/j.cell.2024.07.016.
Cell. 2024.
PMID: 39121848
Guidelines for minimal information on cellular senescence experimentation in vivo.
Ogrodnik M, Carlos Acosta J, Adams PD, d'Adda di Fagagna F, Baker DJ, Bishop CL, Chandra T, Collado M, Gil J, Gorgoulis V, Gruber F, Hara E, Jansen-Dürr P, Jurk D, Khosla S, Kirkland JL, Krizhanovsky V, Minamino T, Niedernhofer LJ, Passos JF, Ring NAR, Redl H, Robbins PD, Rodier F, Scharffetter-Kochanek K, Sedivy JM, Sikora E, Witwer K, von Zglinicki T, Yun MH, Grillari J, Demaria M.
Ogrodnik M, et al.
Cell. 2024 Aug 8;187(16):4150-4175. doi: 10.1016/j.cell.2024.05.059.
Cell. 2024.
PMID: 39121846
Free article.
Review.
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Stress-sensitive neural circuits change the gut microbiome via duodenal glands.
Chang H, Perkins MH, Novaes LS, Qian F, Zhang T, Neckel PH, Scherer S, Ley RE, Han W, de Araujo IE.
Chang H, et al.
Cell. 2024 Aug 1:S0092-8674(24)00779-7. doi: 10.1016/j.cell.2024.07.019. Online ahead of print.
Cell. 2024.
PMID: 39121857
Free article.
Item in Clipboard
LAG-3 sustains TOX expression and regulates the CD94/NKG2-Qa-1b axis to govern exhausted CD8 T cell NK receptor expression and cytotoxicity.
Ngiow SF, Manne S, Huang YJ, Azar T, Chen Z, Mathew D, Chen Q, Khan O, Wu JE, Alcalde V, Flowers AJ, McClain S, Baxter AE, Kurachi M, Shi J, Huang AC, Giles JR, Sharpe AH, Vignali DAA, Wherry EJ.
Ngiow SF, et al.
Cell. 2024 Aug 8;187(16):4336-4354.e19. doi: 10.1016/j.cell.2024.07.018.
Cell. 2024.
PMID: 39121847
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Blockade of LAG-3 and PD-1 leads to co-expression of cytotoxic and exhaustion gene modules in CD8+ T cells to promote antitumor immunity.
Cillo AR, Cardello C, Shan F, Karapetyan L, Kunning S, Sander C, Rush E, Karunamurthy A, Massa RC, Rohatgi A, Workman CJ, Kirkwood JM, Bruno TC, Vignali DAA.
Cillo AR, et al.
Cell. 2024 Aug 8;187(16):4373-4388.e15. doi: 10.1016/j.cell.2024.06.036.
Cell. 2024.
PMID: 39121849
Clinical Trial.
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Anti-LAG-3 boosts CD8 T cell effector function.
Kureshi CT, Dougan M, Dougan SK.
Kureshi CT, et al.
Cell. 2024 Aug 8;187(16):4144-4146. doi: 10.1016/j.cell.2024.07.004.
Cell. 2024.
PMID: 39121844
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Prying the lid open: Atomic-level insights on sialoglycan-TMPRSS2 coordination in HKU1 entry.
Parsons RJ, Acharya P.
Parsons RJ, et al.
Cell. 2024 Aug 8;187(16):4147-4149. doi: 10.1016/j.cell.2024.07.007.
Cell. 2024.
PMID: 39121845
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The need to diversify genomic studies: Insights from Andean highlanders and Amazonians.
Alvim I, Silva-Carvalho C, Mendes de Aquino M, Borda V, Sanchez C, Padilla C, Cáceres O, Rezende-Diniz I, Saraiva-Duarte J, Faria-Costa L, Santolalla ML, Rodrigues-Soares F, Zolini C, Llerena A, O'Connor TD, Gilman RH, Guio H, Tarazona-Santos E.
Alvim I, et al.
Cell. 2024 Sep 5;187(18):4819-4823. doi: 10.1016/j.cell.2024.07.009. Epub 2024 Aug 8.
Cell. 2024.
PMID: 39121858
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