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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1944 1
1945 193
1946 793
1947 955
1948 1014
1949 888
1950 1472
1951 1648
1952 1572
1953 1739
1954 2001
1955 2456
1956 2929
1957 2959
1958 2919
1959 2780
1960 2751
1961 2833
1962 3305
1963 4522
1964 5822
1965 4685
1966 4630
1967 5455
1968 6262
1969 6845
1970 6940
1971 7806
1972 8260
1973 8804
1974 8972
1975 8463
1976 8049
1977 7915
1978 8054
1979 8664
1980 8820
1981 8827
1982 9406
1983 9911
1984 10427
1985 10720
1986 10966
1987 10652
1988 10742
1989 11246
1990 11976
1991 11821
1992 11526
1993 11970
1994 11889
1995 11543
1996 11966
1997 11962
1998 12230
1999 12434
2000 12625
2001 12591
2002 12685
2003 13676
2004 14104
2005 15191
2006 15949
2007 16619
2008 17102
2009 17027
2010 17711
2011 18403
2012 19033
2013 19330
2014 19166
2015 18907
2016 18577
2017 18885
2018 19208
2019 19883
2020 20656
2021 20797
2022 21848
2023 19873
2024 17868
2025 7663
2026 2

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767,737 results

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Page 1
A review on alcohol: from the central action mechanism to chemical dependency.
Costardi JV, Nampo RA, Silva GL, Ribeiro MA, Stella HJ, Stella MB, Malheiros SV. Costardi JV, et al. Rev Assoc Med Bras (1992). 2015 Aug;61(4):381-7. doi: 10.1590/1806-9282.61.04.381. Rev Assoc Med Bras (1992). 2015. PMID: 26466222 Free article. Review.
INTRODUCTION: alcohol is a psychotropic depressant of the central nervous system (CNS) that promotes simultaneous changes in several neuronal pathways, exerting a profound neurological impact that leads to various behavioral and biological alterations. …
INTRODUCTION: alcohol is a psychotropic depressant of the central nervous system (CNS) that promotes simultaneou …
Central nervous system depressant effects of fractions of methanol leaf extract of Cissus cornifolia (Baker) Planch.
Yaro AH, Musa AM, Ya'u J, Nazifi AB, Garba K. Yaro AH, et al. Pak J Pharm Sci. 2019 Mar;32(2):563-568. Pak J Pharm Sci. 2019. PMID: 31081767
As part of a continuous research on this medicinal plant to scientifically validate its use in mental derangement, the fractions of the leaf extract were investigated for central nervous system (CNS) depressant effects. Successive fractionation of the …
As part of a continuous research on this medicinal plant to scientifically validate its use in mental derangement, the fractions of the leaf …
Plants and the central nervous system.
Carlini EA. Carlini EA. Pharmacol Biochem Behav. 2003 Jun;75(3):501-12. doi: 10.1016/s0091-3057(03)00112-6. Pharmacol Biochem Behav. 2003. PMID: 12895668 Review.
This review article draws the attention to the many species of plants possessing activity on the central nervous system (CNS). In fact, they cover the whole spectrum of central activity such as psychoanaleptic, psycholeptic and psychodysleptic effects, …
This review article draws the attention to the many species of plants possessing activity on the central nervous system …
The effect of central nervous system depressant, stimulant and hallucinogenic drugs on injury severity in patients admitted for trauma.
Cordovilla-Guardia S, Lardelli-Claret P, Vilar-López R, López-Espuela F, Guerrero-López F, Fernández-Mondéjar E. Cordovilla-Guardia S, et al. Gac Sanit. 2019 Jan-Feb;33(1):4-9. doi: 10.1016/j.gaceta.2017.06.006. Epub 2017 Aug 5. Gac Sanit. 2019. PMID: 28784303 Free article.
Pooled data analyses in previous studies that grouped substances with opposite effects on the central nervous system (CNS) may have masked the influence of substances on injury severity. ...CONCLUSION: CNS depressant drugs had a strong influence on inj …
Pooled data analyses in previous studies that grouped substances with opposite effects on the central nervous system (C …
Association between prescribed central nervous system depressant drugs, comorbidity and cognition among hospitalised older patients: a cross-sectional study.
Siddiqui TG, Cheng S, Gossop M, Kristoffersen ES, Grambaite R, Lundqvist C. Siddiqui TG, et al. BMJ Open. 2020 Jul 27;10(7):e038432. doi: 10.1136/bmjopen-2020-038432. BMJ Open. 2020. PMID: 32718926 Free PMC article.
OBJECTIVES: Central nervous system depressants (CNSDs) such as opioids, benzodiazepine and Z-hypnotics are commonly used. ...
OBJECTIVES: Central nervous system depressants (CNSDs) such as opioids, benzodiazepine and Z-hypnotics are commo …
Trends in Prescribed Central Nervous System Depressant Medications Among Adults Who Regularly Consume Alcohol: United States 1999 to 2014.
Borodovsky JT, Krauss MJ, Chi T, Bierut LJ, Grucza RA. Borodovsky JT, et al. Alcohol Clin Exp Res. 2019 Jul;43(7):1510-1518. doi: 10.1111/acer.14081. Epub 2019 May 28. Alcohol Clin Exp Res. 2019. PMID: 31135997 Free PMC article.
BACKGROUND: Although the risks of using central nervous system depressant (CNS-D) medications with alcohol are well documented, little is known about trends in prescribed use of these medications among individuals who regularly consume alcohol (i.e., t …
BACKGROUND: Although the risks of using central nervous system depressant (CNS-D) medications with alcohol are w …
Central nervous system depressant action of flavonoid glycosides.
Fernández SP, Wasowski C, Loscalzo LM, Granger RE, Johnston GA, Paladini AC, Marder M. Fernández SP, et al. Eur J Pharmacol. 2006 Jun 13;539(3):168-76. doi: 10.1016/j.ejphar.2006.04.004. Epub 2006 Apr 6. Eur J Pharmacol. 2006. PMID: 16698011
The pharmacological effects on the central nervous system (CNS) of a range of available flavonoid glycosides were explored and compared to those of the glycosides 2S-hesperidin and linarin, recently isolated from valeriana. The glycosides 2S-neohesperidin, 2S …
The pharmacological effects on the central nervous system (CNS) of a range of available flavonoid glycosides were explo …
Opioid Initiation and the Hazard of Falls or Fractures Among Older Adults with Varying Levels of Central Nervous System Depressant Burden.
Guan Q, Men S, Juurlink DN, Bronskill SE, Wunsch H, Gomes T. Guan Q, et al. Drugs Aging. 2022 Sep;39(9):729-738. doi: 10.1007/s40266-022-00970-x. Epub 2022 Aug 10. Drugs Aging. 2022. PMID: 35945484
BACKGROUND: Co-prescription of opioids with other central nervous system (CNS) depressants is common but the combination may increase the risk for adverse events such as falls and fractures, particularly among older adults. ...We stratified the cohort …
BACKGROUND: Co-prescription of opioids with other central nervous system (CNS) depressants is common but the com …
Central nervous system depressant activity of an ethyl acetate extract from Ipomoea stans roots.
Herrera-Ruiz M, Gutiérrez C, Enrique Jiménez-Ferrer J, Tortoriello J, Mirón G, León I. Herrera-Ruiz M, et al. J Ethnopharmacol. 2007 Jun 13;112(2):243-7. doi: 10.1016/j.jep.2007.03.004. Epub 2007 Mar 7. J Ethnopharmacol. 2007. PMID: 17482785
Ipomoea stans Cav., popularly known as "tumbavaqueros", is a plant widely used in Mexico for the treatment of epileptic seizures and nervous disorders. This work researched the action of the ethyl acetate extract from the root of I. stans (IS-EAE) on the central …
Ipomoea stans Cav., popularly known as "tumbavaqueros", is a plant widely used in Mexico for the treatment of epileptic seizures and nerv …
In vivo Piroxicam Metabolites: Possible Source for Synthesis of Central Nervous System (CNS) Acting Depressants.
Saganuwan SA. Saganuwan SA. Cent Nerv Syst Agents Med Chem. 2017;17(3):172-177. doi: 10.2174/1871524917666161111093759. Cent Nerv Syst Agents Med Chem. 2017. PMID: 27834137 Review.
BACKGROUND: Piroxicam has been reported to be convertible to Central Nervous System (CNS) acting agents. It has serious depressant effects at high doses. OBJECTIVE: In view of this, structures of piroxicam metabolites were assessed for possible convers …
BACKGROUND: Piroxicam has been reported to be convertible to Central Nervous System (CNS) acting agents. It has serious …
767,737 results
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