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Aceroside VIII is a new natural selective HDAC6 inhibitor that synergistically enhances the anticancer activity of HDAC inhibitor in HT29 cells.
Ryu HW, Lee DH, Shin DH, Kim SH, Kwon SH. Ryu HW, et al. Planta Med. 2015 Feb;81(3):222-7. doi: 10.1055/s-0034-1396149. Epub 2015 Jan 15. Planta Med. 2015. PMID: 25590368
Aceroside VIII, paltyphyllone, and (-)-centrolobol synergistically enhanced the induction of apoptosis and growth inhibition by A452. Consistent with these results, A452 in combination with aceroside VIII, paltyphyllone, or (-)-centrolobol was more potent than eithe …
Aceroside VIII, paltyphyllone, and (-)-centrolobol synergistically enhanced the induction of apoptosis and growth inhibition by A452. …
Antifibrotic activity of diarylheptanoids from Betula platyphylla toward HSC-T6 cells.
Lee M, Park JH, Min DS, Yoo H, Park JH, Kim YC, Sung SH. Lee M, et al. Biosci Biotechnol Biochem. 2012;76(9):1616-20. doi: 10.1271/bbb.110887. Epub 2012 Sep 7. Biosci Biotechnol Biochem. 2012. PMID: 22972321 Free article.
A chemical investigation of the n-butanol fraction of the inner bark of Betula platyphylla led to the isolation of seven diarylhepanoids, (-)-centrolobol (1), aceroside VII (2), aceroside VIII (3), (3R)-1,7-bis-(4-hydroxyphenyl)-3- …
A chemical investigation of the n-butanol fraction of the inner bark of Betula platyphylla led to the isolation of seven diarylhepanoids, (- …
Sesquiterpenoids and diarylheptanoids from Nidus vespae and their inhibitory effects on nitric oxide production.
He JB, Yan YM, Ma XJ, Lu Q, Li XS, Su J, Li Y, Liu GM, Cheng YX. He JB, et al. Chem Biodivers. 2011 Dec;8(12):2270-6. doi: 10.1002/cbdv.201000366. Chem Biodivers. 2011. PMID: 22162164
Two coriamyrtin-type sesquiterpenes, fengfangin A (1) and tutin (2), and six diarylheptanoids, namely alnusone (3), centrolobol (4), muricarpone B (5), 1-(3,4-dihydroxyphenyl)-7-(4-hydroxyphenyl)heptan-3-one (6), (3S)-1-(3,4-dihydroxyphenyl)-7-(4-hydroxyphenyl)heptan-3-ol …
Two coriamyrtin-type sesquiterpenes, fengfangin A (1) and tutin (2), and six diarylheptanoids, namely alnusone (3), centrolobol (4), …
Osteogenic activity of diphenyl ether-type cyclic diarylheptanoids derived from Acer nikoense.
Yonezawa T, Lee JW, Akazawa H, Inagaki M, Cha BY, Nagai K, Yagasaki K, Akihisa T, Woo JT. Yonezawa T, et al. Bioorg Med Chem Lett. 2011 Jun 1;21(11):3248-51. doi: 10.1016/j.bmcl.2011.04.041. Epub 2011 Apr 17. Bioorg Med Chem Lett. 2011. PMID: 21550801
Osteogenic activity of six diarylheptanoids, acerogenin A (1), (R)-acerogenin B (2), aceroside I (3), aceroside B(1) (4), aceroside III (5) and (-)-centrolobol (6) and two phenolic compounds; (+)-rhododendrol (7) and (+)-cathechin (8), isolated from the stem bark of Acer n …
Osteogenic activity of six diarylheptanoids, acerogenin A (1), (R)-acerogenin B (2), aceroside I (3), aceroside B(1) (4), aceroside III (5) …
Identification of centrolobol as the platyphylloside metabolite responsible for the observed effect on in vitro digestibility of hay.
Sunnerheim K, Bratt K. Sunnerheim K, et al. J Agric Food Chem. 2004 Sep 22;52(19):5869-72. doi: 10.1021/jf040135e. J Agric Food Chem. 2004. PMID: 15366834
Syntheses of the metabolites from platyphylloside, a phenol causing digestibility inhibition in rumen fluid, have been performed to identify the active metabolite. 1,7-Bis(4'-hydroxyphenyl)-3-heptanone (3-platyphyllone), racemic, and the two enantiomers of 1,7-bi …
Syntheses of the metabolites from platyphylloside, a phenol causing digestibility inhibition in rumen fluid, have been performed to identify …
Platyphylloside: Metabolism and digestibility reductionin vitro.
Sunnerheim-Sjöberg K, Knutsson PG. Sunnerheim-Sjöberg K, et al. J Chem Ecol. 1995 Sep;21(9):1339-48. doi: 10.1007/BF02027566. J Chem Ecol. 1995. PMID: 24234631
Platyphylloside is hydrolyzed to 5-hydroxy-3-platyphyllone [(5S)-5-hydroxy-1,7-bis-(4-hydroxyphenyl)-3-heptanone], which is reduced to centrolobol [1,7-bis-(4-hydroxyphenyl)-3-heptanol], via 3-platyphyllone [7-bis-(4-hydroxy …
Platyphylloside is hydrolyzed to 5-hydroxy-3-platyphyllone [(5S)-5-hydroxy-1,7-bis-(4-hydroxyphenyl)-3-heptanone], which is reduced to ce …