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Showing results for cetsa ca
Your search for Cetra CA retrieved no results
HiBiT Cellular Thermal Shift Assay (HiBiT CETSA).
Ramachandran S, Szewczyk M, Barghout SH, Ciulli A, Barsyte-Lovejoy D, Vu V. Ramachandran S, et al. Methods Mol Biol. 2023;2706:149-165. doi: 10.1007/978-1-0716-3397-7_11. Methods Mol Biol. 2023. PMID: 37558947
Thus, CETSA can be used to measure a compound's cellular target engagement and permeability. HiBiT CETSA method is quantitative and has higher throughput compared to the traditional Western-based CETSA. ...
Thus, CETSA can be used to measure a compound's cellular target engagement and permeability. HiBiT CETSA method is quantitativ …
Caffeic acid ameliorates metabolic dysfunction-associated steatotic liver disease via alleviating oxidative damage and lipid accumulation in hepatocytes through activating Nrf2 via targeting Keap1.
Zhang J, Ouyang H, Gu X, Dong S, Lu B, Huang Z, Li J, Ji L. Zhang J, et al. Free Radic Biol Med. 2024 Nov 1;224:352-365. doi: 10.1016/j.freeradbiomed.2024.08.038. Epub 2024 Aug 28. Free Radic Biol Med. 2024. PMID: 39209138
Co-immunoprecipitation (CoIP), cellular thermal shift assay (CETSA) and surface plasmon resonance (SPR) were used to validate the binding between CA and its target protein. ...CA could directly bind to kelch-like ECH-associated protein 1 (Keap1) that is an Nr …
Co-immunoprecipitation (CoIP), cellular thermal shift assay (CETSA) and surface plasmon resonance (SPR) were used to validate the bin …
Cucurbitacin B inhibits non-small cell lung cancer in vivo and in vitro by triggering TLR4/NLRP3/GSDMD-dependent pyroptosis.
Yuan R, Zhao W, Wang QQ, He J, Han S, Gao H, Feng Y, Yang S. Yuan R, et al. Pharmacol Res. 2021 Aug;170:105748. doi: 10.1016/j.phrs.2021.105748. Epub 2021 Jul 1. Pharmacol Res. 2021. PMID: 34217831 Free article.
Next, based on the molecular docking and cellular thermal shift assay (CETSA), we identified that CuB directly bound to Toll-like receptor 4 (TLR4) to activate the NLRP3 inflammasome, which further caused the separation of N- and C-terminals of Gasdermin D (GSDMD) to execu …
Next, based on the molecular docking and cellular thermal shift assay (CETSA), we identified that CuB directly bound to Toll-like rec …
Mfn2 induces NCLX-mediated calcium release from mitochondria.
Kolitsida P, Saha A, Caliri A, Assali E, Riera AM, Itskanov S, Magana CS, Stork B, Shirihai O, Sekler I, Koehler CM, van der Bliek AM. Kolitsida P, et al. bioRxiv [Preprint]. 2024 Aug 13:2024.08.05.606704. doi: 10.1101/2024.08.05.606704. bioRxiv. 2024. PMID: 39149365 Free PMC article. Preprint.
PXA-induced calcium release is blocked by a chemical inhibitor of NCLX, while NCLX and Mfn2 deletions both also prevent PXA-induced calcium release. CETSA experiments show that PXA directly targets Mfn2, which likely controls NCLX through physical interactions since co-imm …
PXA-induced calcium release is blocked by a chemical inhibitor of NCLX, while NCLX and Mfn2 deletions both also prevent PXA-induced calcium …
Lidocaine potentiates thermal ablation in cholangiocarcinoma by modulating TRPV6-Driven Ca(2+)/PI3K/AKT/HSF-1 signaling pathway.
Chen PP, Lin YK, Xia MX, Feng HB, Pan YF, Tan YX, Xu MY, Xing XH, Yao XM, Hu B, Wang HY, Qin WH, Dong LW. Chen PP, et al. Cancer Lett. 2026 Feb 28;639:218226. doi: 10.1016/j.canlet.2025.218226. Epub 2025 Dec 18. Cancer Lett. 2026. PMID: 41421662
Mechanistically, it selectively inhibited TRPV6-mediated store-operated calcium entry (SOCE), disrupting the Ca(2+)/PI3K/AKT/HSF-1 signaling axis, suppressing HSF-1 nuclear translocation, and downregulating cytoprotective HSP70. Direct binding between lidocaine and TRPV6 w …
Mechanistically, it selectively inhibited TRPV6-mediated store-operated calcium entry (SOCE), disrupting the Ca(2+)/PI3K/AKT/HSF-1 si …
Epimedokoreanin B blocks autophagic flux to inhibit progression of triple negative breast cancer through targeting MCOLN1/TRPML1 channel.
Zhao C, Zhang P, Yang X, Liu M, Guan Z, Ma B, Duan X, Su C. Zhao C, et al. Free Radic Biol Med. 2025 Dec 1;240:222-237. doi: 10.1016/j.freeradbiomed.2025.08.041. Epub 2025 Aug 20. Free Radic Biol Med. 2025. PMID: 40846097
Mechanistically, EKB directly binds MCOLN1/TRPML1, thereby promoting lysosomal Ca(2+) efflux and impairing lysosomal acidification. This disruption specifically blocks autophagosome-lysosome fusion, leading to autophagic flux inhibition and subsequent accumulation of intra …
Mechanistically, EKB directly binds MCOLN1/TRPML1, thereby promoting lysosomal Ca(2+) efflux and impairing lysosomal acidification. T …
Glycyrrhetinic acid orchestrates ERS-pyroptosis crosstalk to elicit immunogenic cell death in hepatocellular carcinoma.
Bian M, Ji J, Lian N, Li Y, Zhu W, Cao P, Zhang F. Bian M, et al. Phytomedicine. 2025 Nov 25;148:157309. doi: 10.1016/j.phymed.2025.157309. Epub 2025 Sep 25. Phytomedicine. 2025. PMID: 41038149
Transmission electron microscopy (TEM), intracellular calcium (Ca(2+)) assays, ROS staining, and immunofluorescence were used to investigate GA-induced endoplasmic reticulum stress (ERS) and pyroptosis in HCC cells. Proteomics and transcriptomics were applied to profile ch …
Transmission electron microscopy (TEM), intracellular calcium (Ca(2+)) assays, ROS staining, and immunofluorescence were used to inve …
Isocucurbitacin B inhibits gliomas through the promotion of anoikis by targeting caveolin 1.
Han M, Yang J, Chen P, Li S, Tang H, Fan H, Wang Y, Li X, Pan W, Koutouratsas V, Zhao Z, Peng F. Han M, et al. Cancer Lett. 2025 Oct 1;629:217873. doi: 10.1016/j.canlet.2025.217873. Epub 2025 Jun 12. Cancer Lett. 2025. PMID: 40516904
Additionally, isocucurbitacin B activates the BKCa calcium channel, resulting in increased intracellular Ca(2+) and reduced pH, establishing a novel connection between calcium dynamics and anoikis. ...
Additionally, isocucurbitacin B activates the BKCa calcium channel, resulting in increased intracellular Ca(2+) and reduced pH, estab …
Bisabolangelone targets CSF1R to impede osteoclastogenesis and attenuate estrogen-deficiency bone loss.
Mo L, Xue Y, Zheng X, Wang G, Zou J, Zhao Z, Ma M, Zhang Y, Lu H, Fan Y, Fang B, He W, Xu J, Liu Y. Mo L, et al. Phytomedicine. 2025 Nov 25;148:157472. doi: 10.1016/j.phymed.2025.157472. Epub 2025 Oct 26. Phytomedicine. 2025. PMID: 41202377
Additionally, molecular docking, molecular dynamics simulation and cellular thermal shift assay (CETSA) were employed to investigate the targeting effect of Bisabolangelone on CSF1R. ...Mechanistically, the compound quenched MAPK and Ca(2+)-NFATc1 cascades, blunted …
Additionally, molecular docking, molecular dynamics simulation and cellular thermal shift assay (CETSA) were employed to investigate …
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