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The structural and functional workings of KEOPS.
Beenstock J, Sicheri F. Beenstock J, et al. Nucleic Acids Res. 2021 Nov 8;49(19):10818-10834. doi: 10.1093/nar/gkab865. Nucleic Acids Res. 2021. PMID: 34614169 Free PMC article. Review.
The Kae1 subunit of KEOPS catalyzes the universal and essential tRNA modification N6-threonylcarbamoyl adenosine (t6A), while the auxiliary subunits Cgi121, the kinase/ATPase Bud32, Pcc1 and Gon7 play a supporting role. Kae1 orthologs are also present in bacteria an …
The Kae1 subunit of KEOPS catalyzes the universal and essential tRNA modification N6-threonylcarbamoyl adenosine (t6A), while the aux …
A substrate binding model for the KEOPS tRNA modifying complex.
Beenstock J, Ona SM, Porat J, Orlicky S, Wan LCK, Ceccarelli DF, Maisonneuve P, Szilard RK, Yin Z, Setiaputra D, Mao DYL, Khan M, Raval S, Schriemer DC, Bayfield MA, Durocher D, Sicheri F. Beenstock J, et al. Nat Commun. 2020 Dec 4;11(1):6233. doi: 10.1038/s41467-020-19990-5. Nat Commun. 2020. PMID: 33277478 Free PMC article.
The KEOPS complex, which is conserved across archaea and eukaryotes, is composed of four core subunits; Pcc1, Kae1, Bud32 and Cgi121. ...Kae1 catalyzes the universal and essential tRNA modification N(6)-threonylcarbamoyl adenosine, but the precise roles of all other …
The KEOPS complex, which is conserved across archaea and eukaryotes, is composed of four core subunits; Pcc1, Kae1, Bud32 and Cgi1
Kae1 of Saccharomyces cerevisiae KEOPS complex possesses ADP/GDP nucleotidase activity.
Li QX, Liu JC, He MH, Zhou JQ. Li QX, et al. Biochem J. 2022 Dec 9;479(23):2433-2447. doi: 10.1042/BCJ20220290. Biochem J. 2022. PMID: 36416748
In budding yeast Saccharomyces cerevisiae, the KEOPS complex (ScKEOPS) consists of five subunits, which are Kae1, Bud32, Cgi121, Pcc1, and Gon7. ...In addition, KEOPS could hydrolyze ADP to adenosine or GDP to guanosine, and produce PPi, indicating that KE
In budding yeast Saccharomyces cerevisiae, the KEOPS complex (ScKEOPS) consists of five subunits, which are Kae1, Bud32, Cgi121
Unraveling the Pathobiological Role of the Fungal KEOPS Complex in Cryptococcus neoformans.
Choi Y, Jeong E, Lee DG, Jin JH, So YS, Yu SR, Lee KJ, Ha Y, Lin CJ, Chen YL, Park JB, Cho HS, Averette AF, Heitman J, Lee KH, Lee K, Bahn YS. Choi Y, et al. mBio. 2022 Dec 20;13(6):e0294422. doi: 10.1128/mbio.02944-22. Epub 2022 Nov 15. mBio. 2022. PMID: 36377896 Free PMC article.
This suggests that Pcc1, Kae1, and Bud32 are the core KEOPS components, and Cgi121 may play auxiliary roles. Nevertheless, all KEOPS components were essential for C. neoformans pathogenicity. Although the CnKEOPS complex appeared to have a conserved linear ar …
This suggests that Pcc1, Kae1, and Bud32 are the core KEOPS components, and Cgi121 may play auxiliary roles. Nevertheless, all …
Yeast KEOPS complex regulates telomere length independently of its t(6)A modification function.
Liu YY, He MH, Liu JC, Lu YS, Peng J, Zhou JQ. Liu YY, et al. J Genet Genomics. 2018 May 20;45(5):247-257. doi: 10.1016/j.jgg.2018.03.004. Epub 2018 May 4. J Genet Genomics. 2018. PMID: 29804714
In Saccharomyces cerevisiae, the highly conserved Sua5 and KEOPS complex (including five subunits Kae1, Bud32, Cgi121, Pcc1 and Gon7) catalyze a universal tRNA modification, namely N(6)-threonylcarbamoyladenosine (t(6)A), and regulate telomere replication and recomb …
In Saccharomyces cerevisiae, the highly conserved Sua5 and KEOPS complex (including five subunits Kae1, Bud32, Cgi121, Pcc1 an …
A paralog of Pcc1 is the fifth core subunit of the KEOPS tRNA-modifying complex in Archaea.
Daugeron MC, Missoury S, Da Cunha V, Lazar N, Collinet B, van Tilbeurgh H, Basta T. Daugeron MC, et al. Nat Commun. 2023 Feb 1;14(1):526. doi: 10.1038/s41467-023-36210-y. Nat Commun. 2023. PMID: 36720870 Free PMC article.
In Archaea and Eukaryotes, the synthesis of a universal tRNA modification, N(6)-threonyl-carbamoyl adenosine (t(6)A), is catalyzed by the KEOPS complex composed of Kae1, Bud32, Cgi121, and Pcc1. A fifth subunit, Gon7, is found only in Fungi and Metazoa. ...Pcc2 can …
In Archaea and Eukaryotes, the synthesis of a universal tRNA modification, N(6)-threonyl-carbamoyl adenosine (t(6)A), is catalyzed by the …
Inhibition of telomere recombination by inactivation of KEOPS subunit Cgi121 promotes cell longevity.
Peng J, He MH, Duan YM, Liu YT, Zhou JQ. Peng J, et al. PLoS Genet. 2015 Mar 30;11(3):e1005071. doi: 10.1371/journal.pgen.1005071. eCollection 2015 Mar. PLoS Genet. 2015. PMID: 25822194 Free PMC article.
Here we show that in budding yeast Saccharomyces cerevisiae telomere recombination elicits genome instability and accelerates cellular aging. Inactivation of KEOPS subunit Cgi121 specifically inhibits telomere recombination, and significantly extends cell longevity …
Here we show that in budding yeast Saccharomyces cerevisiae telomere recombination elicits genome instability and accelerates cellular aging …
Crystal structures of the Gon7/Pcc1 and Bud32/Cgi121 complexes provide a model for the complete yeast KEOPS complex.
Zhang W, Collinet B, Graille M, Daugeron MC, Lazar N, Libri D, Durand D, van Tilbeurgh H. Zhang W, et al. Nucleic Acids Res. 2015 Mar 31;43(6):3358-72. doi: 10.1093/nar/gkv155. Epub 2015 Mar 3. Nucleic Acids Res. 2015. PMID: 25735745 Free PMC article.
The yeast KEOPS protein complex comprising Kae1, Bud32, Cgi121, Pcc1 and Gon7 is responsible for the essential tRNA threonylcarbamoyladenosine (t(6)A) modification. ...Gon7 interacts with the same Pcc1 region engaged in the archaeal Pcc1 homodimer. We further show t …
The yeast KEOPS protein complex comprising Kae1, Bud32, Cgi121, Pcc1 and Gon7 is responsible for the essential tRNA threonylca …
Atomic structure of the KEOPS complex: an ancient protein kinase-containing molecular machine.
Mao DY, Neculai D, Downey M, Orlicky S, Haffani YZ, Ceccarelli DF, Ho JS, Szilard RK, Zhang W, Ho CS, Wan L, Fares C, Rumpel S, Kurinov I, Arrowsmith CH, Durocher D, Sicheri F. Mao DY, et al. Mol Cell. 2008 Oct 24;32(2):259-75. doi: 10.1016/j.molcel.2008.10.002. Mol Cell. 2008. PMID: 18951093 Free PMC article.
In archaea and eukaryotes, Kae1 is embedded within the protein kinase-containing KEOPS complex. Mutation of KEOPS subunits in yeast leads to striking telomere and transcription defects, but the exact biochemical function of KEOPS is not known. As a first step …
In archaea and eukaryotes, Kae1 is embedded within the protein kinase-containing KEOPS complex. Mutation of KEOPS subunits in …
Proteomic analysis of the human KEOPS complex identifies C14ORF142 as a core subunit homologous to yeast Gon7.
Wan LC, Maisonneuve P, Szilard RK, Lambert JP, Ng TF, Manczyk N, Huang H, Laister R, Caudy AA, Gingras AC, Durocher D, Sicheri F. Wan LC, et al. Nucleic Acids Res. 2017 Jan 25;45(2):805-817. doi: 10.1093/nar/gkw1181. Epub 2016 Nov 29. Nucleic Acids Res. 2017. PMID: 27903914 Free PMC article.
In archaea and eukaryotes, KEOPS is composed of OSGEP/Kae1, PRPK/Bud32, TPRKB/Cgi121 and LAGE3/Pcc1. ...To identify a Gon7 ortholog in multicellular eukaryotes as well as to uncover KEOPS-interacting proteins that may link t(6)A biosynthesis to the diverse se …
In archaea and eukaryotes, KEOPS is composed of OSGEP/Kae1, PRPK/Bud32, TPRKB/Cgi121 and LAGE3/Pcc1. ...To identify a Gon7 ort …
21 results