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A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents.
Finan B, Yang B, Ottaway N, Smiley DL, Ma T, Clemmensen C, Chabenne J, Zhang L, Habegger KM, Fischer K, Campbell JE, Sandoval D, Seeley RJ, Bleicher K, Uhles S, Riboulet W, Funk J, Hertel C, Belli S, Sebokova E, Conde-Knape K, Konkar A, Drucker DJ, Gelfanov V, Pfluger PT, Müller TD, Perez-Tilve D, DiMarchi RD, Tschöp MH. Finan B, et al. Among authors: chabenne j. Nat Med. 2015 Jan;21(1):27-36. doi: 10.1038/nm.3761. Epub 2014 Dec 8. Nat Med. 2015. PMID: 25485909
Structural Refinement of Glucagon for Therapeutic Use.
Chabenne JR, Mroz PA, Mayer JP, DiMarchi RD. Chabenne JR, et al. J Med Chem. 2020 Apr 9;63(7):3447-3460. doi: 10.1021/acs.jmedchem.9b01493. Epub 2019 Dec 18. J Med Chem. 2020. PMID: 31774682 Review.
Direct control of brown adipose tissue thermogenesis by central nervous system glucagon-like peptide-1 receptor signaling.
Lockie SH, Heppner KM, Chaudhary N, Chabenne JR, Morgan DA, Veyrat-Durebex C, Ananthakrishnan G, Rohner-Jeanrenaud F, Drucker DJ, DiMarchi R, Rahmouni K, Oldfield BJ, Tschöp MH, Perez-Tilve D. Lockie SH, et al. Among authors: chabenne jr. Diabetes. 2012 Nov;61(11):2753-62. doi: 10.2337/db11-1556. Epub 2012 Aug 28. Diabetes. 2012. PMID: 22933116 Free PMC article.
13 results