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RNA interference-mediated suppression and replacement of human rhodopsin in vivo.
O'Reilly M, Palfi A, Chadderton N, Millington-Ward S, Ader M, Cronin T, Tuohy T, Auricchio A, Hildinger M, Tivnan A, McNally N, Humphries MM, Kiang AS, Humphries P, Kenna PF, Farrar GJ. O'Reilly M, et al. Among authors: chadderton n. Am J Hum Genet. 2007 Jul;81(1):127-35. doi: 10.1086/519025. Epub 2007 May 23. Am J Hum Genet. 2007. PMID: 17564969 Free PMC article.
A transgenic mouse model for gene therapy of rhodopsin-linked Retinitis Pigmentosa.
O'Reilly M, Millington-Ward S, Palfi A, Chadderton N, Cronin T, McNally N, Humphries MM, Humphries P, Kenna PF, Farrar GJ. O'Reilly M, et al. Among authors: chadderton n. Vision Res. 2008 Feb;48(3):386-91. doi: 10.1016/j.visres.2007.08.014. Epub 2007 Oct 24. Vision Res. 2008. PMID: 17920651 Free article.
Therapeutic benefit derived from RNAi-mediated ablation of IMPDH1 transcripts in a murine model of autosomal dominant retinitis pigmentosa (RP10).
Tam LC, Kiang AS, Kennan A, Kenna PF, Chadderton N, Ader M, Palfi A, Aherne A, Ayuso C, Campbell M, Reynolds A, McKee A, Humphries MM, Farrar GJ, Humphries P. Tam LC, et al. Among authors: chadderton n. Hum Mol Genet. 2008 Jul 15;17(14):2084-100. doi: 10.1093/hmg/ddn107. Epub 2008 Apr 1. Hum Mol Genet. 2008. PMID: 18385099
AAV-mediated chronic over-expression of SNAP-25 in adult rat dorsal hippocampus impairs memory-associated synaptic plasticity.
McKee AG, Loscher JS, O'Sullivan NC, Chadderton N, Palfi A, Batti L, Sheridan GK, O'Shea S, Moran M, McCabe O, Fernández AB, Pangalos MN, O'Connor JJ, Regan CM, O'Connor WT, Humphries P, Farrar GJ, Murphy KJ. McKee AG, et al. Among authors: chadderton n. J Neurochem. 2010 Feb;112(4):991-1004. doi: 10.1111/j.1471-4159.2009.06516.x. Epub 2009 Nov 30. J Neurochem. 2010. PMID: 20002519 Free article.
Protection of photoreceptors in a mouse model of RP10.
Tam LC, Kiang AS, Chadderton N, Kenna PF, Campbell M, Humphries MM, Farrar GJ, Humphries P. Tam LC, et al. Among authors: chadderton n. Adv Exp Med Biol. 2010;664:559-65. doi: 10.1007/978-1-4419-1399-9_64. Adv Exp Med Biol. 2010. PMID: 20238059
Gene-based therapies for dominantly inherited retinopathies.
Farrar GJ, Millington-Ward S, Chadderton N, Humphries P, Kenna PF. Farrar GJ, et al. Among authors: chadderton n. Gene Ther. 2012 Feb;19(2):137-44. doi: 10.1038/gt.2011.172. Epub 2011 Nov 17. Gene Ther. 2012. PMID: 22089493 Review.
34 results