Chae HY - Search Results

1

Calcium signaling in pancreatic β-cells in health and in Type 2 diabetes.

Gilon P, Chae HY, Rutter GA, Ravier MA. Gilon P, et al. Among authors: chae hy. Cell Calcium. 2014 Nov;56(5):340-61. doi: 10.1016/j.ceca.2014.09.001. Epub 2014 Sep 8. Cell Calcium. 2014. PMID: 25239387 Review.

2

Tolbutamide controls glucagon release from mouse islets differently than glucose: involvement of K(ATP) channels from both α-cells and δ-cells.

Cheng-Xue R, Gómez-Ruiz A, Antoine N, Noël LA, Chae HY, Ravier MA, Chimienti F, Schuit FC, Gilon P. Cheng-Xue R, et al. Among authors: chae hy. Diabetes. 2013 May;62(5):1612-22. doi: 10.2337/db12-0347. Epub 2013 Feb 4. Diabetes. 2013. PMID: 23382449 Free PMC article.

3

Can Tea Extracts Exert a Protective Effect Against Diabetes by Reducing Oxidative Stress and Decreasing Glucotoxicity in Pancreatic β-Cells?

Chae H, Gilon P. Chae H, et al. Diabetes Metab J. 2015 Feb;39(1):27-30. doi: 10.4093/dmj.2015.39.1.27. Diabetes Metab J. 2015. PMID: 25729709 Free PMC article. No abstract available.

4

NNT reverse mode of operation mediates glucose control of mitochondrial NADPH and glutathione redox state in mouse pancreatic β-cells.

Santos LRB, Muller C, de Souza AH, Takahashi HK, Spégel P, Sweet IR, Chae H, Mulder H, Jonas JC. Santos LRB, et al. Mol Metab. 2017 Apr 21;6(6):535-547. doi: 10.1016/j.molmet.2017.04.004. eCollection 2017 Jun. Mol Metab. 2017. PMID: 28580284 Free PMC article.

5

Somatostatin Is Only Partly Required for the Glucagonostatic Effect of Glucose but Is Necessary for the Glucagonostatic Effect of K_ATP Channel Blockers.

Lai BK, Chae H, Gómez-Ruiz A, Cheng P, Gallo P, Antoine N, Beauloye C, Jonas JC, Seghers V, Seino S, Gilon P. Lai BK, et al. Diabetes. 2018 Nov;67(11):2239-2253. doi: 10.2337/db17-0880. Epub 2018 Aug 16. Diabetes. 2018. PMID: 30115649

6

Metallothionein 1 negatively regulates glucose-stimulated insulin secretion and is differentially expressed in conditions of beta cell compensation and failure in mice and humans.

Bensellam M, Shi YC, Chan JY, Laybutt DR, Chae H, Abou-Samra M, Pappas EG, Thomas HE, Gilon P, Jonas JC. Bensellam M, et al. Diabetologia. 2019 Dec;62(12):2273-2286. doi: 10.1007/s00125-019-05008-3. Epub 2019 Oct 17. Diabetologia. 2019. PMID: 31624901

7

SGLT2 is not expressed in pancreatic α- and β-cells, and its inhibition does not directly affect glucagon and insulin secretion in rodents and humans.

Chae H, Augustin R, Gatineau E, Mayoux E, Bensellam M, Antoine N, Khattab F, Lai BK, Brusa D, Stierstorfer B, Klein H, Singh B, Ruiz L, Pieper M, Mark M, Herrera PL, Gribble FM, Reimann F, Wojtusciszyn A, Broca C, Rita N, Piemonti L, Gilon P. Chae H, et al. Mol Metab. 2020 Dec;42:101071. doi: 10.1016/j.molmet.2020.101071. Epub 2020 Sep 5. Mol Metab. 2020. PMID: 32896668 Free PMC article.

8

K_ATP channel blockers control glucagon secretion by distinct mechanisms: A direct stimulation of α-cells involving a [Ca²⁺]_c rise and an indirect inhibition mediated by somatostatin.

Singh B, Khattab F, Chae H, Desmet L, Herrera PL, Gilon P. Singh B, et al. Mol Metab. 2021 Nov;53:101268. doi: 10.1016/j.molmet.2021.101268. Epub 2021 Jun 9. Mol Metab. 2021. PMID: 34118477 Free PMC article.

9

In depth functional characterization of human induced pluripotent stem cell-derived beta cells in vitro and in vivo.

Fantuzzi F, Toivonen S, Schiavo AA, Chae H, Tariq M, Sawatani T, Pachera N, Cai Y, Vinci C, Virgilio E, Ladriere L, Suleiman M, Marchetti P, Jonas JC, Gilon P, Eizirik DL, Igoillo-Esteve M, Cnop M. Fantuzzi F, et al. Front Cell Dev Biol. 2022 Aug 17;10:967765. doi: 10.3389/fcell.2022.967765. eCollection 2022. Front Cell Dev Biol. 2022. PMID: 36060810 Free PMC article.

10

Prolonged culture of human pancreatic islets under glucotoxic conditions changes their acute beta cell calcium and insulin secretion glucose response curves from sigmoid to bell-shaped.

Tariq M, de Souza AH, Bensellam M, Chae H, Jaffredo M, Close AF, Deglasse JP, Santos LRB, Buemi A, Mourad NI, Wojtusciszyn A, Raoux M, Gilon P, Broca C, Jonas JC. Tariq M, et al. Diabetologia. 2023 Apr;66(4):709-723. doi: 10.1007/s00125-022-05842-y. Epub 2022 Dec 2. Diabetologia. 2023. PMID: 36459178

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