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Design of Conformationally Constrained Acyl Sulfonamide Isosteres: Identification of N-([1,2,4]Triazolo[4,3- a]pyridin-3-yl)methane-sulfonamides as Potent and Selective hNaV1.7 Inhibitors for the Treatment of Pain.
Focken T, Chowdhury S, Zenova A, Grimwood ME, Chabot C, Sheng T, Hemeon I, Decker SM, Wilson M, Bichler P, Jia Q, Sun S, Young C, Lin S, Goodchild SJ, Shuart NG, Chang E, Xie Z, Li B, Khakh K, Bankar G, Waldbrook M, Kwan R, Nelkenbrecher K, Karimi Tari P, Chahal N, Sojo L, Robinette CL, White AD, Chen CA, Zhang Y, Pang J, Chang JH, Hackos DH, Johnson JP Jr, Cohen CJ, Ortwine DF, Sutherlin DP, Dehnhardt CM, Safina BS. Focken T, et al. Among authors: chahal n. J Med Chem. 2018 Jun 14;61(11):4810-4831. doi: 10.1021/acs.jmedchem.7b01826. Epub 2018 May 23. J Med Chem. 2018. PMID: 29737846
Discovery of Aryl Sulfonamides as Isoform-Selective Inhibitors of NaV1.7 with Efficacy in Rodent Pain Models.
Focken T, Liu S, Chahal N, Dauphinais M, Grimwood ME, Chowdhury S, Hemeon I, Bichler P, Bogucki D, Waldbrook M, Bankar G, Sojo LE, Young C, Lin S, Shuart N, Kwan R, Pang J, Chang JH, Safina BS, Sutherlin DP, Johnson JP Jr, Dehnhardt CM, Mansour TS, Oballa RM, Cohen CJ, Robinette CL. Focken T, et al. Among authors: chahal n. ACS Med Chem Lett. 2016 Jan 19;7(3):277-82. doi: 10.1021/acsmedchemlett.5b00447. eCollection 2016 Mar 10. ACS Med Chem Lett. 2016. PMID: 26985315 Free PMC article.
Potent, Gut-Restricted Inhibitors of Divalent Metal Transporter 1: Preclinical Efficacy against Iron Overload and Safety Evaluation.
Cutts A, Chowdhury S, Ratkay LG, Eyers M, Young C, Namdari R, Cadieux JA, Chahal N, Grimwood M, Zhang Z, Lin S, Tietjen I, Xie Z, Robinette L, Sojo L, Waldbrook M, Hayden M, Mansour T, Pimstone S, Goldberg YP, Webb M, Cohen CJ. Cutts A, et al. Among authors: chahal n. J Pharmacol Exp Ther. 2023 Jul;386(1):4-14. doi: 10.1124/jpet.122.001435. Epub 2023 Mar 23. J Pharmacol Exp Ther. 2023. PMID: 36958846
METformin for the MINimization of Geographic Atrophy Progression (METforMIN): A Randomized Trial.
Shen LL, Keenan JD, Chahal N, Taha AT, Saroya J, Ma CJ, Sun M, Yang D, Psaras C, Callander J, Flaxel C, Fawzi AA, Schlesinger TK, Wong RW, Bryan Leung LS, Eaton AM, Steinle NC, Telander DG, Afshar AR, Neuwelt MD, Lim JI, Yiu GC, Stewart JM. Shen LL, et al. Among authors: chahal n. Ophthalmol Sci. 2023 Dec 4;4(3):100440. doi: 10.1016/j.xops.2023.100440. eCollection 2024 May-Jun. Ophthalmol Sci. 2023. PMID: 38284098 Free PMC article.
Socioeconomic Status and Kawasaki Disease Outcomes in a Single-Payer Health Care System.
Wong JP, Runeckles K, Manlhiot C, O'Shea S, Collins T, Bernknopf B, Farid P, Chahal N, McCrindle BW. Wong JP, et al. Among authors: chahal n. CJC Pediatr Congenit Heart Dis. 2022 Nov 1;1(6):248-252. doi: 10.1016/j.cjcpc.2022.10.007. eCollection 2022 Dec. CJC Pediatr Congenit Heart Dis. 2022. PMID: 37969486 Free PMC article.
Contrast echocardiography: a practical guideline from the British Society of Echocardiography.
Hampson R, Senior R, Ring L, Robinson S, Augustine DX, Becher H, Anderson N, Willis J, Chandrasekaran B, Kardos A, Siva A, Leeson P, Rana BS, Chahal N, Oxborough D. Hampson R, et al. Among authors: chahal n. Echo Res Pract. 2023 Nov 15;10(1):23. doi: 10.1186/s44156-023-00034-9. Echo Res Pract. 2023. PMID: 37964335 Free PMC article. Review.
126 results