Chaikuad A - Search Results

1

Structure-Based Identification of Inhibitory Fragments Targeting the p300/CBP-Associated Factor Bromodomain.

Chaikuad A, Lang S, Brennan PE, Temperini C, Fedorov O, Hollander J, Nachane R, Abell C, Müller S, Siegal G, Knapp S. Chaikuad A, et al. J Med Chem. 2016 Feb 25;59(4):1648-53. doi: 10.1021/acs.jmedchem.5b01719. Epub 2016 Jan 13. J Med Chem. 2016. PMID: 26731131 Free PMC article.

2

Structural comparison of human mammalian ste20-like kinases.

Record CJ, Chaikuad A, Rellos P, Das S, Pike AC, Fedorov O, Marsden BD, Knapp S, Lee WH. Record CJ, et al. Among authors: chaikuad a. PLoS One. 2010 Aug 6;5(8):e11905. doi: 10.1371/journal.pone.0011905. PLoS One. 2010. PMID: 20730082 Free PMC article.

3

Structure of the bone morphogenetic protein receptor ALK2 and implications for fibrodysplasia ossificans progressiva.

Chaikuad A, Alfano I, Kerr G, Sanvitale CE, Boergermann JH, Triffitt JT, von Delft F, Knapp S, Knaus P, Bullock AN. Chaikuad A, et al. J Biol Chem. 2012 Oct 26;287(44):36990-8. doi: 10.1074/jbc.M112.365932. Epub 2012 Sep 12. J Biol Chem. 2012. PMID: 22977237 Free PMC article.

4

Structural basis for Cul3 protein assembly with the BTB-Kelch family of E3 ubiquitin ligases.

Canning P, Cooper CDO, Krojer T, Murray JW, Pike ACW, Chaikuad A, Keates T, Thangaratnarajah C, Hojzan V, Marsden BD, Gileadi O, Knapp S, von Delft F, Bullock AN. Canning P, et al. Among authors: chaikuad a. J Biol Chem. 2013 Mar 15;288(11):7803-7814. doi: 10.1074/jbc.M112.437996. Epub 2013 Jan 24. J Biol Chem. 2013. PMID: 23349464 Free PMC article.

5

Mechanism and consequence of the autoactivation of p38α mitogen-activated protein kinase promoted by TAB1.

DeNicola GF, Martin ED, Chaikuad A, Bassi R, Clark J, Martino L, Verma S, Sicard P, Tata R, Atkinson RA, Knapp S, Conte MR, Marber MS. DeNicola GF, et al. Among authors: chaikuad a. Nat Struct Mol Biol. 2013 Oct;20(10):1182-90. doi: 10.1038/nsmb.2668. Epub 2013 Sep 15. Nat Struct Mol Biol. 2013. PMID: 24037507 Free PMC article.

6

Targeting low-druggability bromodomains: fragment based screening and inhibitor design against the BAZ2B bromodomain.

Ferguson FM, Fedorov O, Chaikuad A, Philpott M, Muniz JR, Felletar I, von Delft F, Heightman T, Knapp S, Abell C, Ciulli A. Ferguson FM, et al. Among authors: chaikuad a. J Med Chem. 2013 Dec 27;56(24):10183-7. doi: 10.1021/jm401582c. Epub 2013 Dec 13. J Med Chem. 2013. PMID: 24304323 Free PMC article.

7

Structure of cyclin G-associated kinase (GAK) trapped in different conformations using nanobodies.

Chaikuad A, Keates T, Vincke C, Kaufholz M, Zenn M, Zimmermann B, Gutiérrez C, Zhang RG, Hatzos-Skintges C, Joachimiak A, Muyldermans S, Herberg FW, Knapp S, Müller S. Chaikuad A, et al. Biochem J. 2014 Apr 1;459(1):59-69. doi: 10.1042/BJ20131399. Biochem J. 2014. PMID: 24438162 Free PMC article.

8

Copper is required for oncogenic BRAF signalling and tumorigenesis.

Brady DC, Crowe MS, Turski ML, Hobbs GA, Yao X, Chaikuad A, Knapp S, Xiao K, Campbell SL, Thiele DJ, Counter CM. Brady DC, et al. Among authors: chaikuad a. Nature. 2014 May 22;509(7501):492-6. doi: 10.1038/nature13180. Epub 2014 Apr 9. Nature. 2014. PMID: 24717435 Free PMC article.

9

Modulation of the chromatin phosphoproteome by the Haspin protein kinase.

Maiolica A, de Medina-Redondo M, Schoof EM, Chaikuad A, Villa F, Gatti M, Jeganathan S, Lou HJ, Novy K, Hauri S, Toprak UH, Herzog F, Meraldi P, Penengo L, Turk BE, Knapp S, Linding R, Aebersold R. Maiolica A, et al. Among authors: chaikuad a. Mol Cell Proteomics. 2014 Jul;13(7):1724-40. doi: 10.1074/mcp.M113.034819. Epub 2014 Apr 14. Mol Cell Proteomics. 2014. PMID: 24732914 Free PMC article.

10

A unique inhibitor binding site in ERK1/2 is associated with slow binding kinetics.

Chaikuad A, Tacconi EM, Zimmer J, Liang Y, Gray NS, Tarsounas M, Knapp S. Chaikuad A, et al. Nat Chem Biol. 2014 Oct;10(10):853-60. doi: 10.1038/nchembio.1629. Epub 2014 Sep 7. Nat Chem Biol. 2014. PMID: 25195011 Free PMC article.

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