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LUBAC determines chemotherapy resistance in squamous cell lung cancer.
Ruiz EJ, Diefenbacher ME, Nelson JK, Sancho R, Pucci F, Chakraborty A, Moreno P, Annibaldi A, Liccardi G, Encheva V, Mitter R, Rosenfeldt M, Snijders AP, Meier P, Calzado MA, Behrens A. Ruiz EJ, et al. Among authors: chakraborty a. J Exp Med. 2019 Feb 4;216(2):450-465. doi: 10.1084/jem.20180742. Epub 2019 Jan 14. J Exp Med. 2019. PMID: 30642944 Free PMC article.
Usp28 counteracts Fbw7 in intestinal homeostasis and cancer.
Diefenbacher ME, Chakraborty A, Blake SM, Mitter R, Popov N, Eilers M, Behrens A. Diefenbacher ME, et al. Among authors: chakraborty a. Cancer Res. 2015 Apr 1;75(7):1181-6. doi: 10.1158/0008-5472.CAN-14-1726. Epub 2015 Feb 25. Cancer Res. 2015. PMID: 25716680 Free PMC article.
JunD, not c-Jun, is the AP-1 transcription factor required for Ras-induced lung cancer.
Ruiz EJ, Lan L, Diefenbacher ME, Riising EM, Da Costa C, Chakraborty A, Hoeck JD, Spencer-Dene B, Kelly G, David JP, Nye E, Downward J, Behrens A. Ruiz EJ, et al. Among authors: chakraborty a. JCI Insight. 2021 Jul 8;6(13):e124985. doi: 10.1172/jci.insight.124985. JCI Insight. 2021. PMID: 34236045 Free PMC article.
KRASG12C inhibitor: combing for combination.
Chakraborty A. Chakraborty A. Biochem Soc Trans. 2020 Dec 18;48(6):2691-2701. doi: 10.1042/BST20200473. Biochem Soc Trans. 2020. PMID: 33242077 Review.
Discovery of AZD4625, a Covalent Allosteric Inhibitor of the Mutant GTPase KRASG12C.
Kettle JG, Bagal SK, Bickerton S, Bodnarchuk MS, Boyd S, Breed J, Carbajo RJ, Cassar DJ, Chakraborty A, Cosulich S, Cumming I, Davies M, Davies NL, Eatherton A, Evans L, Feron L, Fillery S, Gleave ES, Goldberg FW, Hanson L, Harlfinger S, Howard M, Howells R, Jackson A, Kemmitt P, Lamont G, Lamont S, Lewis HJ, Liu L, Niedbala MJ, Phillips C, Polanski R, Raubo P, Robb G, Robinson DM, Ross S, Sanders MG, Tonge M, Whiteley R, Wilkinson S, Yang J, Zhang W. Kettle JG, et al. Among authors: chakraborty a. J Med Chem. 2022 May 12;65(9):6940-6952. doi: 10.1021/acs.jmedchem.2c00369. Epub 2022 Apr 26. J Med Chem. 2022. PMID: 35471939
2,438 results