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Minireview: human obesity-lessons from monogenic disorders.
O'Rahilly S, Farooqi IS, Yeo GS, Challis BG. O'Rahilly S, et al. Among authors: challis bg. Endocrinology. 2003 Sep;144(9):3757-64. doi: 10.1210/en.2003-0373. Endocrinology. 2003. PMID: 12933645 Review.
Fumarate Metabolic Signature for the Detection of Reed Syndrome in Humans.
Casey RT, McLean MA, Challis BG, McVeigh TP, Warren AY, Mendil L, Houghton R, De Sanctis S, Kosmoliaptsis V, Sandford RN, Gallagher FA, Maher ER. Casey RT, et al. Among authors: challis bg. Clin Cancer Res. 2020 Jan 15;26(2):391-396. doi: 10.1158/1078-0432.CCR-19-1729. Epub 2019 Oct 21. Clin Cancer Res. 2020. PMID: 31636096
A missense mutation disrupting a dibasic prohormone processing site in pro-opiomelanocortin (POMC) increases susceptibility to early-onset obesity through a novel molecular mechanism.
Challis BG, Pritchard LE, Creemers JW, Delplanque J, Keogh JM, Luan J, Wareham NJ, Yeo GS, Bhattacharyya S, Froguel P, White A, Farooqi IS, O'Rahilly S. Challis BG, et al. Hum Mol Genet. 2002 Aug 15;11(17):1997-2004. doi: 10.1093/hmg/11.17.1997. Hum Mol Genet. 2002. PMID: 12165561
Mice lacking pro-opiomelanocortin are sensitive to high-fat feeding but respond normally to the acute anorectic effects of peptide-YY(3-36).
Challis BG, Coll AP, Yeo GS, Pinnock SB, Dickson SL, Thresher RR, Dixon J, Zahn D, Rochford JJ, White A, Oliver RL, Millington G, Aparicio SA, Colledge WH, Russ AP, Carlton MB, O'Rahilly S. Challis BG, et al. Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4695-700. doi: 10.1073/pnas.0306931101. Epub 2004 Mar 15. Proc Natl Acad Sci U S A. 2004. PMID: 15070780 Free PMC article.
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