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Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14.
Ames RS, Sarau HM, Chambers JK, Willette RN, Aiyar NV, Romanic AM, Louden CS, Foley JJ, Sauermelch CF, Coatney RW, Ao Z, Disa J, Holmes SD, Stadel JM, Martin JD, Liu WS, Glover GI, Wilson S, McNulty DE, Ellis CE, Elshourbagy NA, Shabon U, Trill JJ, Hay DW, Ohlstein EH, Bergsma DJ, Douglas SA. Ames RS, et al. Among authors: chambers jk. Nature. 1999 Sep 16;401(6750):282-6. doi: 10.1038/45809. Nature. 1999. PMID: 10499587
Receptor for the pain modulatory neuropeptides FF and AF is an orphan G protein-coupled receptor.
Elshourbagy NA, Ames RS, Fitzgerald LR, Foley JJ, Chambers JK, Szekeres PG, Evans NA, Schmidt DB, Buckley PT, Dytko GM, Murdock PR, Milligan G, Groarke DA, Tan KB, Shabon U, Nuthulaganti P, Wang DY, Wilson S, Bergsma DJ, Sarau HM. Elshourbagy NA, et al. Among authors: chambers jk. J Biol Chem. 2000 Aug 25;275(34):25965-71. doi: 10.1074/jbc.M004515200. J Biol Chem. 2000. PMID: 10851242 Free article.
Orphan G-protein-coupled receptors: the next generation of drug targets?
Wilson S, Bergsma DJ, Chambers JK, Muir AI, Fantom KG, Ellis C, Murdock PR, Herrity NC, Stadel JM. Wilson S, et al. Among authors: chambers jk. Br J Pharmacol. 1998 Dec;125(7):1387-92. doi: 10.1038/sj.bjp.0702238. Br J Pharmacol. 1998. PMID: 9884064 Free PMC article. Review.
A G protein-coupled receptor for UDP-glucose.
Chambers JK, Macdonald LE, Sarau HM, Ames RS, Freeman K, Foley JJ, Zhu Y, McLaughlin MM, Murdock P, McMillan L, Trill J, Swift A, Aiyar N, Taylor P, Vawter L, Naheed S, Szekeres P, Hervieu G, Scott C, Watson JM, Murphy AJ, Duzic E, Klein C, Bergsma DJ, Wilson S, Livi GP. Chambers JK, et al. J Biol Chem. 2000 Apr 14;275(15):10767-71. doi: 10.1074/jbc.275.15.10767. J Biol Chem. 2000. PMID: 10753868 Free article.
Neuromedin U is a potent agonist at the orphan G protein-coupled receptor FM3.
Szekeres PG, Muir AI, Spinage LD, Miller JE, Butler SI, Smith A, Rennie GI, Murdock PR, Fitzgerald LR, Wu Hl, McMillan LJ, Guerrera S, Vawter L, Elshourbagy NA, Mooney JL, Bergsma DJ, Wilson S, Chambers JK. Szekeres PG, et al. Among authors: chambers jk. J Biol Chem. 2000 Jul 7;275(27):20247-50. doi: 10.1074/jbc.C000244200. J Biol Chem. 2000. PMID: 10811630 Free article.
Molecular cloning and functional characterization of MCH2, a novel human MCH receptor.
Hill J, Duckworth M, Murdock P, Rennie G, Sabido-David C, Ames RS, Szekeres P, Wilson S, Bergsma DJ, Gloger IS, Levy DS, Chambers JK, Muir AI. Hill J, et al. Among authors: chambers jk. J Biol Chem. 2001 Jun 8;276(23):20125-9. doi: 10.1074/jbc.M102068200. Epub 2001 Mar 27. J Biol Chem. 2001. PMID: 11274220 Free article.
AXOR12, a novel human G protein-coupled receptor, activated by the peptide KiSS-1.
Muir AI, Chamberlain L, Elshourbagy NA, Michalovich D, Moore DJ, Calamari A, Szekeres PG, Sarau HM, Chambers JK, Murdock P, Steplewski K, Shabon U, Miller JE, Middleton SE, Darker JG, Larminie CG, Wilson S, Bergsma DJ, Emson P, Faull R, Philpott KL, Harrison DC. Muir AI, et al. Among authors: chambers jk. J Biol Chem. 2001 Aug 3;276(31):28969-75. doi: 10.1074/jbc.M102743200. Epub 2001 May 31. J Biol Chem. 2001. PMID: 11387329 Free article.
266 results