Chambers MS - Search Results

1

Spiropiperidines as high-affinity, selective sigma ligands.

Chambers MS, Baker R, Billington DC, Knight AK, Middlemiss DN, Wong EH. Chambers MS, et al. J Med Chem. 1992 May 29;35(11):2033-9. doi: 10.1021/jm00089a013. J Med Chem. 1992. PMID: 1317923

2

Synthesis and serotonergic activity of 5-(oxadiazolyl)tryptamines: potent agonists for 5-HT1D receptors.

Street LJ, Baker R, Castro JL, Chambers MS, Guiblin AR, Hobbs SC, Matassa VG, Reeve AJ, Beer MS, Middlemiss DN, et al. Street LJ, et al. Among authors: chambers ms. J Med Chem. 1993 May 28;36(11):1529-38. doi: 10.1021/jm00063a003. J Med Chem. 1993. PMID: 8496922

3

N-heteroaryl-2-phenyl-3-(benzyloxy)piperidines: a novel class of potent orally active human NK1 antagonists.

Ladduwahetty T, Baker R, Cascieri MA, Chambers MS, Haworth K, Keown LE, MacIntyre DE, Metzger JM, Owen S, Rycroft W, Sadowski S, Seward EM, Shepheard SL, Swain CJ, Tattersall FD, Watt AP, Williamson DW, Hargreaves RJ. Ladduwahetty T, et al. Among authors: chambers ms. J Med Chem. 1996 Jul 19;39(15):2907-14. doi: 10.1021/jm9506534. J Med Chem. 1996. PMID: 8709125

4

3-(Piperazinylpropyl)indoles: selective, orally bioavailable h5-HT1D receptor agonists as potential antimigraine agents.

Chambers MS, Street LJ, Goodacre S, Hobbs SC, Hunt P, Jelley RA, Matassa VG, Reeve AJ, Sternfeld F, Beer MS, Stanton JA, Rathbone D, Watt AP, MacLeod AM. Chambers MS, et al. J Med Chem. 1999 Feb 25;42(4):691-705. doi: 10.1021/jm980569z. J Med Chem. 1999. PMID: 10052976

5

Identification of a novel, selective GABA(A) alpha5 receptor inverse agonist which enhances cognition.

Chambers MS, Atack JR, Broughton HB, Collinson N, Cook S, Dawson GR, Hobbs SC, Marshall G, Maubach KA, Pillai GV, Reeve AJ, MacLeod AM. Chambers MS, et al. J Med Chem. 2003 May 22;46(11):2227-40. doi: 10.1021/jm020582q. J Med Chem. 2003. PMID: 12747794

6

3,4-Dihydronaphthalen-1(2H)-ones: novel ligands for the benzodiazepine site of alpha5-containing GABAA receptors.

Szekeres HJ, Atack JR, Chambers MS, Cook SM, Macaulay AJ, Pillai GV, MacLeod AM. Szekeres HJ, et al. Among authors: chambers ms. Bioorg Med Chem Lett. 2004 Jun 7;14(11):2871-5. doi: 10.1016/j.bmcl.2004.03.054. Bioorg Med Chem Lett. 2004. PMID: 15125950

7

An orally bioavailable, functionally selective inverse agonist at the benzodiazepine site of GABAA alpha5 receptors with cognition enhancing properties.

Chambers MS, Atack JR, Carling RW, Collinson N, Cook SM, Dawson GR, Ferris P, Hobbs SC, O'connor D, Marshall G, Rycroft W, Macleod AM. Chambers MS, et al. J Med Chem. 2004 Nov 18;47(24):5829-32. doi: 10.1021/jm040863t. J Med Chem. 2004. PMID: 15537339

8

Pharmacokinetics and metabolism studies on (3-tert-butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy) pyrazolo[1,5-d][1,2,4]triazine, a functionally selective GABA(A) alpha5 inverse agonist for cognitive dysfunction.

Jones P, Atack JR, Braun MP, Cato BP, Chambers MS, O'Connor D, Cook SM, Hobbs SC, Maxey R, Szekeres HJ, Szeto N, Wafford KA, MacLeod AM. Jones P, et al. Among authors: chambers ms. Bioorg Med Chem Lett. 2006 Feb 15;16(4):872-5. doi: 10.1016/j.bmcl.2005.11.012. Epub 2005 Nov 21. Bioorg Med Chem Lett. 2006. PMID: 16303300

9

6,7-Dihydro-2-benzothiophen-4(5H)-ones: a novel class of GABA-A alpha5 receptor inverse agonists.

Chambers MS, Atack JR, Bromidge FA, Broughton HB, Cook S, Dawson GR, Hobbs SC, Maubach KA, Reeve AJ, Seabrook GR, Wafford K, MacLeod AM. Chambers MS, et al. J Med Chem. 2002 Mar 14;45(6):1176-9. doi: 10.1021/jm010471b. J Med Chem. 2002. PMID: 11881985

10

CCK-B antagonists in the control of anxiety and gastric acid secretion.

Chambers MS, Fletcher SR. Chambers MS, et al. Prog Med Chem. 2000;37:45-81. doi: 10.1016/s0079-6468(08)70057-2. Prog Med Chem. 2000. PMID: 10845247 Review. No abstract available.

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