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Translational stroke research of the combination of thrombolysis and antioxidant therapy.
Amaro S, Chamorro Á. Amaro S, et al. Among authors: chamorro a. Stroke. 2011 May;42(5):1495-9. doi: 10.1161/STROKEAHA.111.615039. Epub 2011 Apr 7. Stroke. 2011. PMID: 21474803
Edaravone and novel nitrones endowed with a better pharmacokinetic profile or multitarget and thrombolytic activity are discussed as well as the latest research data on uric acid, a strong endogenous antioxidant in blood that is early consumed after acute stroke. .. …
Edaravone and novel nitrones endowed with a better pharmacokinetic profile or multitarget and thrombolytic activity are discussed as …
[Critical analysis of early heparin therapy in cerebral ischemic infarction].
Chamorro A. Chamorro A. Neurologia. 1995 Feb;10(2):87-91. Neurologia. 1995. PMID: 7695949 Spanish.
This is a critical review of the role of heparin in the acute phase of ischemic cerebral vascular accident (CVA). Completed clinical trials lead to the following conclusions: 1. ...There are prospective studies, on the other hand, that indicate a lack of correlation …
This is a critical review of the role of heparin in the acute phase of ischemic cerebral vascular accident (CVA). Completed clinical …
Contribution of arterial blood pressure to the clinical expression of lacunar infarction.
Chamorro A, Saiz A, Vila N, Ascaso C, Blanc R, Alday M, Pujol J. Chamorro A, et al. Stroke. 1996 Mar;27(3):388-92. doi: 10.1161/01.str.27.3.388. Stroke. 1996. PMID: 8610300
RESULTS: A total of 147 silent infarctions were observed in 83 patients (33%). Most silent infarctions corresponded to small deep lesions in the territory of the lenticulostriate arteries. ...However, a history of arterial hypertension was perhaps unrecognized, sinc …
RESULTS: A total of 147 silent infarctions were observed in 83 patients (33%). Most silent infarctions corresponded to small deep les …
[The effect of clinical trials on hospital admission for stroke].
Vila N, Chamorro A. Vila N, et al. Among authors: chamorro a. Rev Neurol. 1997 Jul;25(143):1129-31. Rev Neurol. 1997. PMID: 9280654 Spanish.
Based on experimental studies, the drugs used in the trial need to be given within a 'therapeutic window' of less than six hours from the onset of the illness. This time factor has led to a radical change in the organization of hospital services dealing with this il …
Based on experimental studies, the drugs used in the trial need to be given within a 'therapeutic window' of less than six hours from …
Cytokine-induced inflammation and long-term stroke functional outcome.
Vila N, Filella X, Deulofeu R, Ascaso C, Abellana R, Chamorro A. Vila N, et al. Among authors: chamorro a. J Neurol Sci. 1999 Jan 15;162(2):185-8. doi: 10.1016/s0022-510x(98)00319-0. J Neurol Sci. 1999. PMID: 10202985 Clinical Trial.
Patients with a Rankin score > or = 3 were classified as dependent outcome. The effect of inflammatory variables on outcome was analyzed by logistic regression. ...On multiple logistic regression, severe stroke on admission, non-lacunar infarct size and ESR remain in th …
Patients with a Rankin score > or = 3 were classified as dependent outcome. The effect of inflammatory variables on outcome was an …
Heparin in acute ischemic stroke: the case for a new clinical trial.
Chamorro A. Chamorro A. Cerebrovasc Dis. 1999;9 Suppl 3:16-23. doi: 10.1159/000047550. Cerebrovasc Dis. 1999. PMID: 10436321 Review. No abstract available.
Ex vivo response to aspirin differs in stroke patients with single or recurrent events: a pilot study.
Chamorro A, Escolar G, Revilla M, Obach V, Vila N, Reverter JC, Ordinas A. Chamorro A, et al. J Neurol Sci. 1999 Dec 15;171(2):110-4. doi: 10.1016/s0022-510x(99)00260-9. J Neurol Sci. 1999. PMID: 10581376 Clinical Trial.
Arachidonic acid and epinephrine promoted a stronger platelet aggregation in aspirin nonresponders than in aspirin responders while taking 300 mg/day aspirin. ...A lower sensitivity to thromboxane receptors was also found during phase 1 of the study, although the re …
Arachidonic acid and epinephrine promoted a stronger platelet aggregation in aspirin nonresponders than in aspirin responders while t …
Polymorphonuclear leukocyte elastase in patients with stroke.
Vila N, Elena M, Deulofeu R, Chamorro A. Vila N, et al. Among authors: chamorro a. Acta Neurol Scand. 1999 Dec;100(6):391-4. doi: 10.1111/j.1600-0404.1999.tb01058.x. Acta Neurol Scand. 1999. PMID: 10589799
Comparison of the acute-phase response in patients with ischemic stroke treated with high-dose heparin or aspirin.
Chamorro A, Obach V, Vila N, Revilla M, Cervera A, Ascaso C. Chamorro A, et al. J Neurol Sci. 2000 Sep 1;178(1):17-22. doi: 10.1016/s0022-510x(00)00345-2. J Neurol Sci. 2000. PMID: 11018244 Clinical Trial.
[Limitations of evidence-based medicine: the case of stroke].
Chamorro A, Alonso P, Arrizabalaga J, Carné X, Camps V. Chamorro A, et al. Med Clin (Barc). 2001 Mar 10;116(9):343-9. doi: 10.1016/s0025-7753(01)71822-2. Med Clin (Barc). 2001. PMID: 11333767 Spanish. No abstract available.
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