Chan G - Search Results

1

PI3K p110δ uniquely promotes gain-of-function Shp2-induced GM-CSF hypersensitivity in a model of JMML.

Goodwin CB, Li XJ, Mali RS, Chan G, Kang M, Liu Z, Vanhaesebroeck B, Neel BG, Loh ML, Lannutti BJ, Kapur R, Chan RJ. Goodwin CB, et al. Among authors: chan rj, chan g. Blood. 2014 May 1;123(18):2838-42. doi: 10.1182/blood-2013-10-535104. Epub 2014 Feb 19. Blood. 2014. PMID: 24553178 Free PMC article.

2

The tyrosine phosphatase Shp2 (PTPN11) in cancer.

Chan G, Kalaitzidis D, Neel BG. Chan G, et al. Cancer Metastasis Rev. 2008 Jun;27(2):179-92. doi: 10.1007/s10555-008-9126-y. Cancer Metastasis Rev. 2008. PMID: 18286234 Review.

3

Leukemogenic Ptpn11 causes fatal myeloproliferative disorder via cell-autonomous effects on multiple stages of hematopoiesis.

Chan G, Kalaitzidis D, Usenko T, Kutok JL, Yang W, Mohi MG, Neel BG. Chan G, et al. Blood. 2009 Apr 30;113(18):4414-24. doi: 10.1182/blood-2008-10-182626. Epub 2009 Jan 29. Blood. 2009. PMID: 19179468 Free PMC article.

4

A germline gain-of-function mutation in Ptpn11 (Shp-2) phosphatase induces myeloproliferative disease by aberrant activation of hematopoietic stem cells.

Xu D, Wang S, Yu WM, Chan G, Araki T, Bunting KD, Neel BG, Qu CK. Xu D, et al. Among authors: chan g. Blood. 2010 Nov 4;116(18):3611-21. doi: 10.1182/blood-2010-01-265652. Epub 2010 Jul 22. Blood. 2010. PMID: 20651068 Free PMC article.

5

Erk1 and Erk2 are required for maintenance of hematopoietic stem cells and adult hematopoiesis.

Chan G, Gu S, Neel BG. Chan G, et al. Blood. 2013 May 2;121(18):3594-8. doi: 10.1182/blood-2012-12-476200. Epub 2013 Feb 26. Blood. 2013. PMID: 23444405 Free PMC article.

6

Essential role for Ptpn11 in survival of hematopoietic stem and progenitor cells.

Chan G, Cheung LS, Yang W, Milyavsky M, Sanders AD, Gu S, Hong WX, Liu AX, Wang X, Barbara M, Sharma T, Gavin J, Kutok JL, Iscove NN, Shannon KM, Dick JE, Neel BG, Braun BS. Chan G, et al. Blood. 2011 Apr 21;117(16):4253-61. doi: 10.1182/blood-2010-11-319517. Epub 2011 Feb 25. Blood. 2011. PMID: 21398220 Free PMC article.

7

Leukemogenic Ptpn11 allele causes defective erythropoiesis in mice.

Usenko T, Chan G, Torlakovic E, Klingmüller U, Neel BG. Usenko T, et al. Among authors: chan g. PLoS One. 2014 Oct 7;9(10):e109682. doi: 10.1371/journal.pone.0109682. eCollection 2014. PLoS One. 2014. PMID: 25289670 Free PMC article.

8

SHP2 is required for BCR-ABL1-induced hematologic neoplasia.

Gu S, Sayad A, Chan G, Yang W, Lu Z, Virtanen C, Van Etten RA, Neel BG. Gu S, et al. Among authors: chan g. Leukemia. 2018 Jan;32(1):203-213. doi: 10.1038/leu.2017.250. Epub 2017 Aug 14. Leukemia. 2018. PMID: 28804122 Free PMC article.

9

Prognostic, therapeutic, and mechanistic implications of a mouse model of leukemia evoked by Shp2 (PTPN11) mutations.

Mohi MG, Williams IR, Dearolf CR, Chan G, Kutok JL, Cohen S, Morgan K, Boulton C, Shigematsu H, Keilhack H, Akashi K, Gilliland DG, Neel BG. Mohi MG, et al. Among authors: chan g. Cancer Cell. 2005 Feb;7(2):179-91. doi: 10.1016/j.ccr.2005.01.010. Cancer Cell. 2005. PMID: 15710330 Free article.

10

Cancer: Bad neighbours cause bad blood.

Chan G, Neel BG. Chan G, et al. Nature. 2016 Nov 10;539(7628):173-175. doi: 10.1038/nature19479. Epub 2016 Oct 26. Nature. 2016. PMID: 27783594 Free PMC article.

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