Chan Hue Sun[au] OR Hue Sun Chan[au] OR (Chan HS[au] AND ((toronto[ad] AND biochemistry [ad]) OR (san francisco[ad] AND pharmaceutical[ad]))) OR (11456842[PMID] OR 11274473[PMID] OR 9973573[PMID] OR 9572133[PMID] OR 7854444[PMID] OR 9957430[PMID] OR - Search Results

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Biological condensates form percolated networks with molecular motion properties distinctly different from dilute solutions.

Shen Z, Jia B, Xu Y, Wessén J, Pal T, Chan HS, Du S, Zhang M. Shen Z, et al. Among authors: chan hs. Elife. 2023 Jun 1;12:e81907. doi: 10.7554/eLife.81907. Online ahead of print. Elife. 2023. PMID: 37261897 Free article.

Analytical Formulation and Field-Theoretic Simulation of Sequence-Specific Phase Separation of Protein-Like Heteropolymers with Short- and Long-Spatial-Range Interactions.

Wessén J, Das S, Pal T, Chan HS. Wessén J, et al. Among authors: chan hs. J Phys Chem B. 2022 Nov 17;126(45):9222-9245. doi: 10.1021/acs.jpcb.2c06181. Epub 2022 Nov 7. J Phys Chem B. 2022. PMID: 36343363

Numerical Techniques for Applications of Analytical Theories to Sequence-Dependent Phase Separations of Intrinsically Disordered Proteins.

Lin YH, Wessén J, Pal T, Das S, Chan HS. Lin YH, et al. Among authors: chan hs. Methods Mol Biol. 2023;2563:51-94. doi: 10.1007/978-1-0716-2663-4_3. Methods Mol Biol. 2023. PMID: 36227468

Field theory description of ion association in re-entrant phase separation of polyampholytes.

Wessén J, Pal T, Chan HS. Wessén J, et al. Among authors: chan hs. J Chem Phys. 2022 May 21;156(19):194903. doi: 10.1063/5.0088326. J Chem Phys. 2022. PMID: 35597632

Effects of Cosolvents and Crowding Agents on the Stability and Phase Transition Kinetics of the SynGAP/PSD-95 Condensate Model of Postsynaptic Densities.

Cinar H, Oliva R, Wu H, Zhang M, Chan HS, Winter R. Cinar H, et al. Among authors: chan hs. J Phys Chem B. 2022 Mar 3;126(8):1734-1741. doi: 10.1021/acs.jpcb.2c00794. Epub 2022 Feb 16. J Phys Chem B. 2022. PMID: 35171623

Assembly of model postsynaptic densities involves interactions auxiliary to stoichiometric binding.

Lin YH, Wu H, Jia B, Zhang M, Chan HS. Lin YH, et al. Among authors: chan hs. Biophys J. 2022 Jan 4;121(1):157-171. doi: 10.1016/j.bpj.2021.10.008. Epub 2021 Oct 9. Biophys J. 2022. PMID: 34637756 Free PMC article.

Small-Angle X-ray Scattering Signatures of Conformational Heterogeneity and Homogeneity of Disordered Protein Ensembles.

Song J, Li J, Chan HS. Song J, et al. Among authors: chan hs. J Phys Chem B. 2021 Jun 24;125(24):6451-6478. doi: 10.1021/acs.jpcb.1c02453. Epub 2021 Jun 11. J Phys Chem B. 2021. PMID: 34115515

Subcompartmentalization of polyampholyte species in organelle-like condensates is promoted by charge-pattern mismatch and strong excluded-volume interaction.

Pal T, Wessén J, Das S, Chan HS. Pal T, et al. Among authors: chan hs. Phys Rev E. 2021 Apr;103(4-1):042406. doi: 10.1103/PhysRevE.103.042406. Phys Rev E. 2021. PMID: 34005864

A Simple Explicit-Solvent Model of Polyampholyte Phase Behaviors and Its Ramifications for Dielectric Effects in Biomolecular Condensates.

Wessén J, Pal T, Das S, Lin YH, Chan HS. Wessén J, et al. Among authors: chan hs. J Phys Chem B. 2021 May 6;125(17):4337-4358. doi: 10.1021/acs.jpcb.1c00954. Epub 2021 Apr 23. J Phys Chem B. 2021. PMID: 33890467

Comparative roles of charge, π, and hydrophobic interactions in sequence-dependent phase separation of intrinsically disordered proteins.

Das S, Lin YH, Vernon RM, Forman-Kay JD, Chan HS. Das S, et al. Among authors: chan hs. Proc Natl Acad Sci U S A. 2020 Nov 17;117(46):28795-28805. doi: 10.1073/pnas.2008122117. Epub 2020 Nov 2. Proc Natl Acad Sci U S A. 2020. PMID: 33139563 Free PMC article.

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