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Another view of the selective model of thymocyte selection.
Chan SH, Cosgrove D, Waltzinger C, Benoist C, Mathis D. Chan SH, et al. Cell. 1993 Apr 23;73(2):225-36. doi: 10.1016/0092-8674(93)90225-f. Cell. 1993. PMID: 8097430
Stable inhibitory activity of regulatory T cells requires the transcription factor Helios.
Kim HJ, Barnitz RA, Kreslavsky T, Brown FD, Moffett H, Lemieux ME, Kaygusuz Y, Meissner T, Holderried TA, Chan S, Kastner P, Haining WN, Cantor H. Kim HJ, et al. Science. 2015 Oct 16;350(6258):334-9. doi: 10.1126/science.aad0616. Science. 2015. PMID: 26472910 Free PMC article.
Ikaros represses the transcriptional response to Notch signaling in T-cell development.
Kleinmann E, Geimer Le Lay AS, Sellars M, Kastner P, Chan S. Kleinmann E, et al. Mol Cell Biol. 2008 Dec;28(24):7465-75. doi: 10.1128/MCB.00715-08. Epub 2008 Oct 13. Mol Cell Biol. 2008. PMID: 18852286 Free PMC article.
Bcl11b represses a mature T-cell gene expression program in immature CD4(+)CD8(+) thymocytes.
Kastner P, Chan S, Vogel WK, Zhang LJ, Topark-Ngarm A, Golonzhka O, Jost B, Le Gras S, Gross MK, Leid M. Kastner P, et al. Eur J Immunol. 2010 Aug;40(8):2143-54. doi: 10.1002/eji.200940258. Eur J Immunol. 2010. PMID: 20544728 Free PMC article.
Helios deficiency has minimal impact on T cell development and function.
Cai Q, Dierich A, Oulad-Abdelghani M, Chan S, Kastner P. Cai Q, et al. J Immunol. 2009 Aug 15;183(4):2303-11. doi: 10.4049/jimmunol.0901407. Epub 2009 Jul 20. J Immunol. 2009. PMID: 19620299
MafB restricts M-CSF-dependent myeloid commitment divisions of hematopoietic stem cells.
Sarrazin S, Mossadegh-Keller N, Fukao T, Aziz A, Mourcin F, Vanhille L, Kelly Modis L, Kastner P, Chan S, Duprez E, Otto C, Sieweke MH. Sarrazin S, et al. Cell. 2009 Jul 23;138(2):300-13. doi: 10.1016/j.cell.2009.04.057. Cell. 2009. PMID: 19632180
Visualizing PU.1 activity during hematopoiesis.
Back J, Allman D, Chan S, Kastner P. Back J, et al. Exp Hematol. 2005 Apr;33(4):395-402. doi: 10.1016/j.exphem.2004.12.010. Exp Hematol. 2005. PMID: 15781329
Ikaros is critical for B cell differentiation and function.
Kirstetter P, Thomas M, Dierich A, Kastner P, Chan S. Kirstetter P, et al. Eur J Immunol. 2002 Mar;32(3):720-30. doi: 10.1002/1521-4141(200203)32:3<720::AID-IMMU720>3.0.CO;2-P. Eur J Immunol. 2002. PMID: 11870616
Ikaros regulates neutrophil differentiation.
Dumortier A, Kirstetter P, Kastner P, Chan S. Dumortier A, et al. Blood. 2003 Mar 15;101(6):2219-26. doi: 10.1182/blood-2002-05-1336. Epub 2002 Oct 24. Blood. 2003. PMID: 12406904
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