Chang CH - Search Results

1

Discovery of (2R)-2-(3-{3-[(4-Methoxyphenyl)carbonyl]-2-methyl-6-(trifluoromethoxy)-1H-indol-1-yl}phenoxy)butanoic acid (MK-0533): a novel selective peroxisome proliferator-activated receptor gamma modulator for the treatment of type 2 diabetes mellitus with a reduced potential to increase plasma and extracellular fluid volume.

Acton JJ 3rd, Akiyama TE, Chang CH, Colwell L, Debenham S, Doebber T, Einstein M, Liu K, McCann ME, Moller DE, Muise ES, Tan Y, Thompson JR, Wong KK, Wu M, Xu L, Meinke PT, Berger JP, Wood HB. Acton JJ 3rd, et al. Among authors: chang ch. J Med Chem. 2009 Jul 9;52(13):3846-54. doi: 10.1021/jm900097m. J Med Chem. 2009. PMID: 19507861

2

A novel selective peroxisome proliferator-activator receptor-gamma modulator-SPPARgammaM5 improves insulin sensitivity with diminished adverse cardiovascular effects.

Chang CH, McNamara LA, Wu MS, Muise ES, Tan Y, Wood HB, Meinke PT, Thompson JR, Doebber TW, Berger JP, McCann ME. Chang CH, et al. Eur J Pharmacol. 2008 Apr 14;584(1):192-201. doi: 10.1016/j.ejphar.2007.12.036. Epub 2008 Feb 14. Eur J Pharmacol. 2008. PMID: 18346728

3

Discovery of a peroxisome proliferator activated receptor gamma (PPARgamma) modulator with balanced PPARalpha activity for the treatment of type 2 diabetes and dyslipidemia.

Liu W, Liu K, Wood HB, McCann ME, Doebber TW, Chang CH, Akiyama TE, Einstein M, Berger JP, Meinke PT. Liu W, et al. Among authors: chang ch. J Med Chem. 2009 Jul 23;52(14):4443-53. doi: 10.1021/jm900367w. J Med Chem. 2009. PMID: 19530681

4

Benzimidazolones: a new class of selective peroxisome proliferator-activated receptor γ (PPARγ) modulators.

Liu W, Lau F, Liu K, Wood HB, Zhou G, Chen Y, Li Y, Akiyama TE, Castriota G, Einstein M, Wang C, McCann ME, Doebber TW, Wu M, Chang CH, McNamara L, McKeever B, Mosley RT, Berger JP, Meinke PT. Liu W, et al. Among authors: chang ch. J Med Chem. 2011 Dec 22;54(24):8541-54. doi: 10.1021/jm201061j. Epub 2011 Nov 28. J Med Chem. 2011. PMID: 22070604

5

Endothelial Cell-Targeted Deletion of PPARγ Blocks Rosiglitazone-Induced Plasma Volume Expansion and Vascular Remodeling in Adipose Tissue.

Akiyama TE, Skelhorne-Gross GE, Lightbody ED, Rubino RE, Shi JY, McNamara LA, Sharma N, Zycband EI, Gonzalez FJ, Liu H, Woods JW, Chang CH, Berger JP, Nicol CJB. Akiyama TE, et al. Among authors: chang ch. J Pharmacol Exp Ther. 2019 Mar;368(3):514-523. doi: 10.1124/jpet.118.250985. Epub 2019 Jan 3. J Pharmacol Exp Ther. 2019. PMID: 30606762

6

ApoA-I mimetic peptides promote pre-β HDL formation in vivo causing remodeling of HDL and triglyceride accumulation at higher dose.

Carballo-Jane E, Chen Z, O'Neill E, Wang J, Burton C, Chang CH, Chen X, Eveland S, Frantz-Wattley B, Gagen K, Hubbard B, Ichetovkin M, Luell S, Meurer R, Song X, Strack A, Langella A, Cianetti S, Rech F, Capitò E, Bufali S, Veneziano M, Verdirame M, Bonelli F, Monteagudo E, Pessi A, Ingenito R, Bianchi E. Carballo-Jane E, et al. Among authors: chang ch. Bioorg Med Chem. 2010 Dec 15;18(24):8669-78. doi: 10.1016/j.bmc.2010.09.074. Epub 2010 Nov 4. Bioorg Med Chem. 2010. PMID: 21115285

7

An apoA-I mimetic peptide increases LCAT activity in mice through increasing HDL concentration.

Chen X, Burton C, Song X, McNamara L, Langella A, Cianetti S, Chang CH, Wang J. Chen X, et al. Among authors: chang ch. Int J Biol Sci. 2009 Jul 28;5(5):489-99. doi: 10.7150/ijbs.5.489. Int J Biol Sci. 2009. PMID: 19680471 Free PMC article.

8

Activity of a novel nonpeptidyl growth hormone secretagogue, L-700,653, in swine.

Chang CH, Rickes EL, Marsilio F, McGuire L, Cosgrove S, Taylor J, Chen H, Feighner S, Clark JN, De Vita R, et al. Chang CH, et al. Endocrinology. 1995 Mar;136(3):1065-71. doi: 10.1210/endo.136.3.7867560. Endocrinology. 1995. PMID: 7867560

9

Modulation of pulsatile GH release through a novel receptor in hypothalamus and pituitary gland.

Smith RG, Pong SS, Hickey G, Jacks T, Cheng K, Leonard R, Cohen CJ, Arena JP, Chang CH, Drisko J, Wyvratt M, Fisher M, Nargund R, Patchett A. Smith RG, et al. Among authors: chang ch. Recent Prog Horm Res. 1996;51:261-85; discussion 285-6. Recent Prog Horm Res. 1996. PMID: 8701083 Review.

10

Growth hormone (GH) and insulin-like growth factor I responses after treatments with an orally active GH secretagogue L-163,255 in swine.

Chang CH, Rickes EL, McGuire L, Frazier E, Chen H, Barakat K, Nargund R, Patchett A, Smith RG, Hickey GJ. Chang CH, et al. Endocrinology. 1996 Nov;137(11):4851-6. doi: 10.1210/endo.137.11.8895356. Endocrinology. 1996. PMID: 8895356

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