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The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR.
Chin RM, Fu X, Pai MY, Vergnes L, Hwang H, Deng G, Diep S, Lomenick B, Meli VS, Monsalve GC, Hu E, Whelan SA, Wang JX, Jung G, Solis GM, Fazlollahi F, Kaweeteerawat C, Quach A, Nili M, Krall AS, Godwin HA, Chang HR, Faull KF, Guo F, Jiang M, Trauger SA, Saghatelian A, Braas D, Christofk HR, Clarke CF, Teitell MA, Petrascheck M, Reue K, Jung ME, Frand AR, Huang J. Chin RM, et al. Among authors: chang hr. Nature. 2014 Jun 19;510(7505):397-401. doi: 10.1038/nature13264. Epub 2014 May 14. Nature. 2014. PMID: 24828042 Free PMC article.
Proteomic profiling of cancer biomarkers.
Shau H, Chandler GS, Whitelegge JP, Gornbein JA, Faull KF, Chang HR. Shau H, et al. Among authors: chang hr. Brief Funct Genomic Proteomic. 2003 Jul;2(2):147-58. doi: 10.1093/bfgp/2.2.147. Brief Funct Genomic Proteomic. 2003. PMID: 15239937 Review.
372 results