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Insights into the anaphase-promoting complex: a molecular machine that regulates mitosis.
Chang L, Barford D. Chang L, et al. Curr Opin Struct Biol. 2014 Dec;29:1-9. doi: 10.1016/j.sbi.2014.08.003. Epub 2014 Aug 24. Curr Opin Struct Biol. 2014. PMID: 25174288 Review.
Cryo-EM structure of a metazoan separase-securin complex at near-atomic resolution.
Boland A, Martin TG, Zhang Z, Yang J, Bai XC, Chang L, Scheres SH, Barford D. Boland A, et al. Among authors: chang l. Nat Struct Mol Biol. 2017 Apr;24(4):414-418. doi: 10.1038/nsmb.3386. Epub 2017 Mar 6. Nat Struct Mol Biol. 2017. PMID: 28263324 Free PMC article.
WD40 domain of Apc1 is critical for the coactivator-induced allosteric transition that stimulates APC/C catalytic activity.
Li Q, Chang L, Aibara S, Yang J, Zhang Z, Barford D. Li Q, et al. Among authors: chang l. Proc Natl Acad Sci U S A. 2016 Sep 20;113(38):10547-52. doi: 10.1073/pnas.1607147113. Epub 2016 Sep 6. Proc Natl Acad Sci U S A. 2016. PMID: 27601667 Free PMC article.
Molecular basis of APC/C regulation by the spindle assembly checkpoint.
Alfieri C, Chang L, Zhang Z, Yang J, Maslen S, Skehel M, Barford D. Alfieri C, et al. Among authors: chang l. Nature. 2016 Aug 25;536(7617):431-436. doi: 10.1038/nature19083. Epub 2016 Aug 10. Nature. 2016. PMID: 27509861 Free PMC article.
Molecular mechanism of APC/C activation by mitotic phosphorylation.
Zhang S, Chang L, Alfieri C, Zhang Z, Yang J, Maslen S, Skehel M, Barford D. Zhang S, et al. Among authors: chang l. Nature. 2016 May 12;533(7602):260-264. doi: 10.1038/nature17973. Epub 2016 Apr 27. Nature. 2016. PMID: 27120157 Free PMC article.
We also find that the small-molecule inhibitor, tosyl-l-arginine methyl ester, preferentially suppresses APC/C(Cdc20) rather than APC/C(Cdh1), and interacts with the binding sites of both the C-box and Ile-Arg tail motifs. ...
We also find that the small-molecule inhibitor, tosyl-l-arginine methyl ester, preferentially suppresses APC/C(Cdc20) rather than APC …
Atomic-Resolution Structures of the APC/C Subunits Apc4 and the Apc5 N-Terminal Domain.
Cronin NB, Yang J, Zhang Z, Kulkarni K, Chang L, Yamano H, Barford D. Cronin NB, et al. Among authors: chang l. J Mol Biol. 2015 Oct 9;427(20):3300-3315. doi: 10.1016/j.jmb.2015.08.023. Epub 2015 Sep 4. J Mol Biol. 2015. PMID: 26343760 Free PMC article.
The four canonical tpr subunits of human APC/C form related homo-dimeric structures and stack in parallel to form a TPR suprahelix.
Zhang Z, Chang L, Yang J, Conin N, Kulkarni K, Barford D. Zhang Z, et al. Among authors: chang l. J Mol Biol. 2013 Nov 15;425(22):4236-48. doi: 10.1016/j.jmb.2013.04.004. Epub 2013 Apr 11. J Mol Biol. 2013. PMID: 23583778 Free PMC article.
Building a pseudo-atomic model of the anaphase-promoting complex.
Kulkarni K, Zhang Z, Chang L, Yang J, da Fonseca PC, Barford D. Kulkarni K, et al. Among authors: chang l. Acta Crystallogr D Biol Crystallogr. 2013 Nov;69(Pt 11):2236-43. doi: 10.1107/S0907444913018593. Epub 2013 Oct 12. Acta Crystallogr D Biol Crystallogr. 2013. PMID: 24189235 Free PMC article.
Mechanism for remodelling of the cell cycle checkpoint protein MAD2 by the ATPase TRIP13.
Alfieri C, Chang L, Barford D. Alfieri C, et al. Among authors: chang l. Nature. 2018 Jul;559(7713):274-278. doi: 10.1038/s41586-018-0281-1. Epub 2018 Jul 4. Nature. 2018. PMID: 29973720 Free PMC article.
The potential of cryo-electron microscopy for structure-based drug design.
Boland A, Chang L, Barford D. Boland A, et al. Among authors: chang l. Essays Biochem. 2017 Nov 8;61(5):543-560. doi: 10.1042/EBC20170032. Print 2017 Nov 8. Essays Biochem. 2017. PMID: 29118099 Review.
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