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HER-2/c-erbB2 is phosphorylated by calmodulin-dependent protein kinase II on a single site in the cytoplasmic tail at threonine-1172.
Feinmesser RL, Gray K, Means AR, Chantry A. Feinmesser RL, et al. Among authors: chantry a. Oncogene. 1996 Jun 20;12(12):2725-30. Oncogene. 1996. PMID: 8700533
A GST fusion protein comprising residues 1126-1255 of HER-2 was phosphorylated by purified Cam kinase II, in contrast to a GST protein comprising residues 1005-1125. Phosphoamino-acid analysis and site-directed mutagenesis indicated that HER-2 was phosphorylated on
A GST fusion protein comprising residues 1126-1255 of HER-2 was phosphorylated by purified Cam kinase II, in contrast to a GST
Decorin suppresses transforming growth factor-beta-induced expression of plasminogen activator inhibitor-1 in human mesangial cells through a mechanism that involves Ca2+-dependent phosphorylation of Smad2 at serine-240.
Abdel-Wahab N, Wicks SJ, Mason RM, Chantry A. Abdel-Wahab N, et al. Among authors: chantry a. Biochem J. 2002 Mar 15;362(Pt 3):643-9. doi: 10.1042/0264-6021:3620643. Biochem J. 2002. PMID: 11879191 Free PMC article.
Transforming growth factor-beta (TGFbeta) is a key mediator of extracellular matrix (ECM) accumulation in sclerotic kidney diseases such as diabetic nephropathy. ...Naturally occurring inhibitors of this TGFbeta-dependent fibrotic response include decorin, a small l …
Transforming growth factor-beta (TGFbeta) is a key mediator of extracellular matrix (ECM) accumulation in sclerotic kidney diseases s …
The deubiquitinating enzyme UCH37 interacts with Smads and regulates TGF-beta signalling.
Wicks SJ, Haros K, Maillard M, Song L, Cohen RE, Dijke PT, Chantry A. Wicks SJ, et al. Among authors: chantry a. Oncogene. 2005 Dec 1;24(54):8080-4. doi: 10.1038/sj.onc.1208944. Oncogene. 2005. PMID: 16027725
Here, we report a novel interaction between Smads and ubiquitin C-terminal hydrolase UCH37, a deubiquitinating enzyme that could potentially reverse Smurf-mediated ubiquitination. ...These findings support a new role for deubiquitinating enzymes in the contro …
Here, we report a novel interaction between Smads and ubiquitin C-terminal hydrolase UCH37, a deubiquitinating enzyme that cou …
Selective targeting of activating and inhibitory Smads by distinct WWP2 ubiquitin ligase isoforms differentially modulates TGFβ signalling and EMT.
Soond SM, Chantry A. Soond SM, et al. Among authors: chantry a. Oncogene. 2011 May 26;30(21):2451-62. doi: 10.1038/onc.2010.617. Epub 2011 Jan 24. Oncogene. 2011. PMID: 21258410 Free PMC article.
In this study, we identify a HECT E3 ubiquitin ligase known as WWP2 (Full-length WWP2-FL), together with two WWP2 isoforms (N-terminal, WWP2-N; C-terminal WWP2-C), as novel Smad-binding partners. ...In addition, WWP2-FL and WWP2-C have a preference for Smad7 based o …
In this study, we identify a HECT E3 ubiquitin ligase known as WWP2 (Full-length WWP2-FL), together with two WWP2 isoforms (N-termina …
Serine mutations that abrogate ligand-induced ubiquitination and internalization of the EGF receptor do not affect c-Cbl association with the receptor.
Oksvold MP, Thien CB, Widerberg J, Chantry A, Huitfeldt HS, Langdon WY. Oksvold MP, et al. Among authors: chantry a. Oncogene. 2003 Nov 20;22(52):8509-18. doi: 10.1038/sj.onc.1207117. Oncogene. 2003. PMID: 14627991
Adjacent carboxyterminal tyrosine phosphorylation events identify functionally distinct ErbB2 receptor subsets: implications for molecular diagnostics.
Ouyang X, Huang GC, Chantry A, Epstein RJ. Ouyang X, et al. Among authors: chantry a. Exp Cell Res. 1998 Jun 15;241(2):467-75. doi: 10.1006/excr.1998.4091. Exp Cell Res. 1998. PMID: 9637788
Site-directed mutagenesis can define the effects of altering one or more amino acids within a protein, but this technique may lack sensitivity when used to characterize proteins which differ conformationally or posttranslationally at multiple sites. A novel alternat …
Site-directed mutagenesis can define the effects of altering one or more amino acids within a protein, but this technique may lack se …
Ca2+/calmodulin-dependent kinase II phosphorylates the epidermal growth factor receptor on multiple sites in the cytoplasmic tail and serine 744 within the kinase domain to regulate signal generation.
Feinmesser RL, Wicks SJ, Taverner CJ, Chantry A. Feinmesser RL, et al. Among authors: chantry a. J Biol Chem. 1999 Jun 4;274(23):16168-73. doi: 10.1074/jbc.274.23.16168. J Biol Chem. 1999. PMID: 10347170
We show that serines 1046/1047 are sites for CaM kinase II phosphorylation, although there is a preference for serine 1047, which resides within the consensus -R-X-X-S-. In addition, we have identified major phosphorylation sites at serine 1142 and serine 1057, which lie w …
We show that serines 1046/1047 are sites for CaM kinase II phosphorylation, although there is a preference for serine 1047, which res …
Inactivation of smad-transforming growth factor beta signaling by Ca(2+)-calmodulin-dependent protein kinase II.
Wicks SJ, Lui S, Abdel-Wahab N, Mason RM, Chantry A. Wicks SJ, et al. Among authors: chantry a. Mol Cell Biol. 2000 Nov;20(21):8103-11. doi: 10.1128/mcb.20.21.8103-8111.2000. Mol Cell Biol. 2000. PMID: 11027280 Free PMC article.
Smad2 is a target substrate for Cam kinase II in vitro at serine-110, -240, and -260. Cam kinase II induces in vivo phosphorylation of Smad2 and Smad4 and, to a lesser extent, Smad3. ...These findings provide a novel cross-talk mechanism by which Ca(2+)-depen …
Smad2 is a target substrate for Cam kinase II in vitro at serine-110, -240, and -260. Cam kinase II induces in vivo phosphorylation o …
Overexpression of ErbB2 impairs ligand-dependent downregulation of epidermal growth factor receptors via a post-transcriptional mechanism.
Huang G, Chantry A, Epstein RJ. Huang G, et al. Among authors: chantry a. J Cell Biochem. 1999 Jul 1;74(1):23-30. J Cell Biochem. 1999. PMID: 10381258
EGFR overexpressors do not contain increased levels of ErbB2, however, tending to exclude a transfection artifact caused by saturation of receptor processing. ...We conclude that ErbB2 expression impairs EGFR downregulation via a posttranscriptional mechanism and pr …
EGFR overexpressors do not contain increased levels of ErbB2, however, tending to exclude a transfection artifact caused by saturatio …
The kinase domain and membrane localization determine intracellular interactions between epidermal growth factor receptors.
Chantry A. Chantry A. J Biol Chem. 1995 Feb 17;270(7):3068-73. J Biol Chem. 1995. PMID: 7531698
Precise mechanisms of receptor dimerization remain poorly understood, and current models suggest that the ligand binding domain plays a major determining role. To examine the role of the intracellular domain in the association of juxtaposing receptor molecules, the full-le …
Precise mechanisms of receptor dimerization remain poorly understood, and current models suggest that the ligand binding domain plays a
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