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Cytoplasmic p21 Mediates 5-Fluorouracil Resistance by Inhibiting Pro-Apoptotic Chk2
Maiuthed A, et al. Cancers (Basel) 2018. Among authors: Chanvorachote P. PMID 30304835 Free PMC article.
Kinase array analysis revealed that p-Chk2 is a key target of cytoplasmic p21. Importantly, cytoplasmic form of p21 mediated by p21(T145D) transfection diminished p-Chk2-mediated activation of E2F1 and apoptosis induction. ...Using in silico computer modeling, we suggest that the p21/p-Chk2 interaction hindered the nuclear localization signal of p-Chk2, and therefore, the complex is exported out of the nucleus. ...
Kinase array analysis revealed that p-Chk2 is a key target of cytoplasmic p21. Importantly, cytoplasmic form of p21 mediated by p21(T …
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