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Productive common light chain libraries yield diverse panels of high affinity bispecific antibodies.
Van Blarcom T, Lindquist K, Melton Z, Cheung WL, Wagstrom C, McDonough D, Valle Oseguera C, Ding S, Rossi A, Potluri S, Sundar P, Pitts S, Sirota M, Galindo Casas M, Yan Y, Jones J, Roe-Zurz Z, Srivatsa Srinivasan S, Zhai W, Pons J, Rajpal A, Chaparro-Riggers J. Van Blarcom T, et al. MAbs. 2018 Feb/Mar;10(2):256-268. doi: 10.1080/19420862.2017.1406570. Epub 2017 Dec 14. MAbs. 2018. PMID: 29227213 Free PMC article.
Generating bispecific human IgG1 and IgG2 antibodies from any antibody pair.
Strop P, Ho WH, Boustany LM, Abdiche YN, Lindquist KC, Farias SE, Rickert M, Appah CT, Pascua E, Radcliffe T, Sutton J, Chaparro-Riggers J, Chen W, Casas MG, Chin SM, Wong OK, Liu SH, Vergara G, Shelton D, Rajpal A, Pons J. Strop P, et al. J Mol Biol. 2012 Jul 13;420(3):204-19. doi: 10.1016/j.jmb.2012.04.020. Epub 2012 Apr 25. J Mol Biol. 2012. PMID: 22543237
Precise and efficient antibody epitope determination through library design, yeast display and next-generation sequencing.
Van Blarcom T, Rossi A, Foletti D, Sundar P, Pitts S, Bee C, Melton Witt J, Melton Z, Hasa-Moreno A, Shaughnessy L, Telman D, Zhao L, Cheung WL, Berka J, Zhai W, Strop P, Chaparro-Riggers J, Shelton DL, Pons J, Rajpal A. Van Blarcom T, et al. J Mol Biol. 2015 Mar 27;427(6 Pt B):1513-1534. doi: 10.1016/j.jmb.2014.09.020. Epub 2014 Oct 2. J Mol Biol. 2015. PMID: 25284753
Epitope Mapping Using Yeast Display and Next Generation Sequencing.
Van Blarcom T, Rossi A, Foletti D, Sundar P, Pitts S, Melton Z, Telman D, Zhao L, Cheung WL, Berka J, Zhai W, Strop P, Pons J, Rajpal A, Chaparro-Riggers J. Van Blarcom T, et al. Methods Mol Biol. 2018;1785:89-118. doi: 10.1007/978-1-4939-7841-0_7. Methods Mol Biol. 2018. PMID: 29714014
Dual checkpoint blockade of CD47 and PD-L1 using an affinity-tuned bispecific antibody maximizes antitumor immunity.
Chen SH, Dominik PK, Stanfield J, Ding S, Yang W, Kurd N, Llewellyn R, Heyen J, Wang C, Melton Z, Van Blarcom T, Lindquist KC, Chaparro-Riggers J, Salek-Ardakani S. Chen SH, et al. Among authors: chaparro riggers j. J Immunother Cancer. 2021 Oct;9(10):e003464. doi: 10.1136/jitc-2021-003464. J Immunother Cancer. 2021. PMID: 34599020 Free PMC article.
Increasing serum half-life and extending cholesterol lowering in vivo by engineering antibody with pH-sensitive binding to PCSK9.
Chaparro-Riggers J, Liang H, DeVay RM, Bai L, Sutton JE, Chen W, Geng T, Lindquist K, Casas MG, Boustany LM, Brown CL, Chabot J, Gomes B, Garzone P, Rossi A, Strop P, Shelton D, Pons J, Rajpal A. Chaparro-Riggers J, et al. J Biol Chem. 2012 Mar 30;287(14):11090-7. doi: 10.1074/jbc.M111.319764. Epub 2012 Jan 31. J Biol Chem. 2012. PMID: 22294692 Free PMC article.
Location matters: site of conjugation modulates stability and pharmacokinetics of antibody drug conjugates.
Strop P, Liu SH, Dorywalska M, Delaria K, Dushin RG, Tran TT, Ho WH, Farias S, Casas MG, Abdiche Y, Zhou D, Chandrasekaran R, Samain C, Loo C, Rossi A, Rickert M, Krimm S, Wong T, Chin SM, Yu J, Dilley J, Chaparro-Riggers J, Filzen GF, O'Donnell CJ, Wang F, Myers JS, Pons J, Shelton DL, Rajpal A. Strop P, et al. Chem Biol. 2013 Feb 21;20(2):161-7. doi: 10.1016/j.chembiol.2013.01.010. Chem Biol. 2013. PMID: 23438745
40 results