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Page 1
Co-receptor Binding Site Antibodies Enable CD4-Mimetics to Expose Conserved Anti-cluster A ADCC Epitopes on HIV-1 Envelope Glycoproteins.
Richard J, Pacheco B, Gohain N, Veillette M, Ding S, Alsahafi N, Tolbert WD, Prévost J, Chapleau JP, Coutu M, Jia M, Brassard N, Park J, Courter JR, Melillo B, Martin L, Tremblay C, Hahn BH, Kaufmann DE, Wu X, Smith AB 3rd, Sodroski J, Pazgier M, Finzi A. Richard J, et al. Among authors: chapleau jp. EBioMedicine. 2016 Oct;12:208-218. doi: 10.1016/j.ebiom.2016.09.004. Epub 2016 Sep 9. EBioMedicine. 2016. PMID: 27633463 Free PMC article.
A New Family of Small-Molecule CD4-Mimetic Compounds Contacts Highly Conserved Aspartic Acid 368 of HIV-1 gp120 and Mediates Antibody-Dependent Cellular Cytotoxicity.
Ding S, Grenier MC, Tolbert WD, Vézina D, Sherburn R, Richard J, Prévost J, Chapleau JP, Gendron-Lepage G, Medjahed H, Abrams C, Sodroski J, Pazgier M, Smith AB 3rd, Finzi A. Ding S, et al. Among authors: chapleau jp. J Virol. 2019 Nov 26;93(24):e01325-19. doi: 10.1128/JVI.01325-19. Print 2019 Dec 15. J Virol. 2019. PMID: 31554684 Free PMC article.
Paring Down HIV Env: Design and Crystal Structure of a Stabilized Inner Domain of HIV-1 gp120 Displaying a Major ADCC Target of the A32 Region.
Tolbert WD, Gohain N, Veillette M, Chapleau JP, Orlandi C, Visciano ML, Ebadi M, DeVico AL, Fouts TR, Finzi A, Lewis GK, Pazgier M. Tolbert WD, et al. Among authors: chapleau jp. Structure. 2016 May 3;24(5):697-709. doi: 10.1016/j.str.2016.03.005. Epub 2016 Mar 31. Structure. 2016. PMID: 27041594 Free PMC article.
Residues in the gp41 Ectodomain Regulate HIV-1 Envelope Glycoprotein Conformational Transitions Induced by gp120-Directed Inhibitors.
Pacheco B, Alsahafi N, Debbeche O, Prévost J, Ding S, Chapleau JP, Herschhorn A, Madani N, Princiotto A, Melillo B, Gu C, Zeng X, Mao Y, Smith AB 3rd, Sodroski J, Finzi A. Pacheco B, et al. Among authors: chapleau jp. J Virol. 2017 Feb 14;91(5):e02219-16. doi: 10.1128/JVI.02219-16. Print 2017 Mar 1. J Virol. 2017. PMID: 28003492 Free PMC article.
Optimization of Small Molecules That Sensitize HIV-1 Infected Cells to Antibody-Dependent Cellular Cytotoxicity.
Grenier MC, Ding S, Vézina D, Chapleau JP, Tolbert WD, Sherburn R, Schön A, Somisetti S, Abrams CF, Pazgier M, Finzi A, Smith AB 3rd. Grenier MC, et al. Among authors: chapleau jp. ACS Med Chem Lett. 2019 Nov 15;11(3):371-378. doi: 10.1021/acsmedchemlett.9b00445. eCollection 2020 Mar 12. ACS Med Chem Lett. 2019. PMID: 32184972 Free PMC article.