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185 results

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The use of human induced pluripotent stem cells to screen for developmental toxicity potential indicates reduced potential for non-combusted products, when compared to cigarettes.
Simms L, Rudd K, Palmer J, Czekala L, Yu F, Chapman F, Trelles Sticken E, Wieczorek R, Bode LM, Stevenson M, Walele T. Simms L, et al. Among authors: chapman f. Curr Res Toxicol. 2020 Nov 15;1:161-173. doi: 10.1016/j.crtox.2020.11.001. eCollection 2020 Jun 10. Curr Res Toxicol. 2020. PMID: 34345845 Free PMC article.
The in vitro ToxTracker and Aneugen Clastogen Evaluation extension assay as a tool in the assessment of relative genotoxic potential of e-liquids and their aerosols.
Czekala L, Chapman F, Simms L, Rudd K, Trelles Sticken E, Wieczorek R, Bode LM, Pani J, Moelijker N, Derr R, Brandsma I, Hendriks G, Stevenson M, Walele T. Czekala L, et al. Among authors: chapman f. Mutagenesis. 2021 May 31;36(2):129-142. doi: 10.1093/mutage/geaa033. Mutagenesis. 2021. PMID: 33769537 Free PMC article.
Reductions in biomarkers of exposure to selected harmful and potentially harmful constituents following exclusive and partial switching from combustible cigarettes to myblu electronic nicotine delivery systems (ENDS).
Morris P, McDermott S, Chapman F, Verron T, Cahours X, Stevenson M, Thompson J, Chaudhary N, O'Connell G. Morris P, et al. Among authors: chapman f. Intern Emerg Med. 2022 Mar;17(2):397-410. doi: 10.1007/s11739-021-02813-w. Epub 2021 Aug 26. Intern Emerg Med. 2022. PMID: 34435305 Free PMC article. Clinical Trial.
A randomised, open-label, cross-over clinical study to evaluate the pharmacokinetic, pharmacodynamic and safety and tolerability profiles of tobacco-free oral nicotine pouches relative to cigarettes.
Chapman F, McDermott S, Rudd K, Taverner V, Stevenson M, Chaudhary N, Reichmann K, Thompson J, Nahde T, O'Connell G. Chapman F, et al. Psychopharmacology (Berl). 2022 Sep;239(9):2931-2943. doi: 10.1007/s00213-022-06178-6. Epub 2022 Jun 23. Psychopharmacology (Berl). 2022. PMID: 35732751 Free PMC article. Clinical Trial.
Multiple endpoint in vitro toxicity assessment of a prototype heated tobacco product indicates substantially reduced effects compared to those of combustible cigarette.
Chapman F, Sticken ET, Wieczorek R, Pour SJ, Dethloff O, Budde J, Rudd K, Mason E, Czekala L, Yu F, Simms L, Nahde T, O'Connell G, Stevenson M. Chapman F, et al. Toxicol In Vitro. 2023 Feb;86:105510. doi: 10.1016/j.tiv.2022.105510. Epub 2022 Nov 11. Toxicol In Vitro. 2023. PMID: 36372310 Free article.
Twenty-eight day repeated exposure of human 3D bronchial epithelial model to heated tobacco aerosols indicates decreased toxicological responses compared to cigarette smoke.
Chapman F, Pour SJ, Wieczorek R, Trelles Sticken E, Budde J, Röwer K, Otte S, Mason E, Czekala L, Nahde T, O'Connell G, Simms L, Stevenson M. Chapman F, et al. Front Toxicol. 2023 Feb 16;5:1076752. doi: 10.3389/ftox.2023.1076752. eCollection 2023. Front Toxicol. 2023. PMID: 36875887 Free PMC article.
Multiple-endpoint in vitro carcinogenicity test in human cell line TK6 distinguishes carcinogens from non-carcinogens and highlights mechanisms of action.
Chapman KE, Wilde EC, Chapman FM, Verma JR, Shah UK, Stannard LM, Seager AL, Tonkin JA, Brown MR, Doherty AT, Johnson GE, Doak SH, Jenkins GJS. Chapman KE, et al. Arch Toxicol. 2021 Jan;95(1):321-336. doi: 10.1007/s00204-020-02902-3. Epub 2020 Sep 10. Arch Toxicol. 2021. PMID: 32910239 Free PMC article.
185 results