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Sequential designs for phase I clinical trials with late-onset toxicities.
Cheung YK, Chappell R. Cheung YK, et al. Among authors: chappell r. Biometrics. 2000 Dec;56(4):1177-82. doi: 10.1111/j.0006-341x.2000.01177.x. Biometrics. 2000. PMID: 11129476
A group sequential, response-adaptive design for randomized clinical trials.
Karrison TG, Huo D, Chappell R. Karrison TG, et al. Among authors: chappell r. Control Clin Trials. 2003 Oct;24(5):506-22. doi: 10.1016/s0197-2456(03)00092-8. Control Clin Trials. 2003. PMID: 14500050 Review.
After the kth interim analysis, if the z-value comparing outcomes in the two treatment groups is less than 1.0 in absolute value, the ratio remains 1:1; if the z-value exceeds 1.0, the next sequential group is allocated in the ratio R(1) favoring the currently better-perfo …
After the kth interim analysis, if the z-value comparing outcomes in the two treatment groups is less than 1.0 in absolute value, the ratio …
Isotonic designs for phase I cancer clinical trials with multiple risk groups.
Yuan Z, Chappell R. Yuan Z, et al. Among authors: chappell r. Clin Trials. 2004;1(6):499-508. doi: 10.1191/1740774504cn058oa. Clin Trials. 2004. PMID: 16279290
Three-dose-cohort designs in cancer phase I trials.
Huang B, Chappell R. Huang B, et al. Among authors: chappell r. Stat Med. 2008 May 30;27(12):2070-93. doi: 10.1002/sim.3054. Stat Med. 2008. PMID: 17764082
Sample size under the additive hazards model.
McDaniel LS, Yu M, Chappell R. McDaniel LS, et al. Among authors: chappell r. Clin Trials. 2016 Apr;13(2):188-98. doi: 10.1177/1740774515614542. Epub 2015 Nov 15. Clin Trials. 2016. PMID: 26572562 Free PMC article.
Modeling daily and subdaily cycles in rat sleep data.
Qiu P, Chappell R, Obermeyer W, Benca R. Qiu P, et al. Among authors: chappell r. Biometrics. 1999 Sep;55(3):930-5. doi: 10.1111/j.0006-341x.1999.00930.x. Biometrics. 1999. PMID: 11315031
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