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Detection of the interaction between host and bacterial proteins: eukaryotic nucleolin interacts with Francisella elongation factor Tu.
Barel M, Charbit A. Barel M, et al. Methods Mol Biol. 2014;1197:123-39. doi: 10.1007/978-1-4939-1261-2_7. Methods Mol Biol. 2014. PMID: 25172278
This facultative intracellular pathogen is the causative agent of tularemia and is considered as a bio-threatening agent. The privileged host cells are monocytes and macrophages. We used both "in vitro" and "in vivo" experiments to explore the modulation of F. tularensis i …
This facultative intracellular pathogen is the causative agent of tularemia and is considered as a bio-threatening agent. The privile …
Maltose transport and starch binding in phage-resistant point mutants of maltoporin. Functional and topological implications.
Charbit A, Gehring K, Nikaido H, Ferenci T, Hofnung M. Charbit A, et al. J Mol Biol. 1988 Jun 5;201(3):487-96. doi: 10.1016/0022-2836(88)90630-4. J Mol Biol. 1988. PMID: 2971116
Class A is composed of mutants with no effect on transport (substitutions at amino acid residues 154, 155, 259, 382 and 401); class B corresponds to mutants with a significant but variable reduction in transport (sites 148, 151, 152, 163, 164, 245, 247 and 250); cla …
Class A is composed of mutants with no effect on transport (substitutions at amino acid residues 154, 155, 259, 382 and 401); class B …
Identification of a PEST-like motif in listeriolysin O required for phagosomal escape and for virulence in Listeria monocytogenes.
Lety MA, Frehel C, Dubail I, Beretti JL, Kayal S, Berche P, Charbit A. Lety MA, et al. Mol Microbiol. 2001 Mar;39(5):1124-39. doi: 10.1111/j.1365-2958.2001.02281.x. Mol Microbiol. 2001. PMID: 11251831
The hly-encoded listeriolysin O (LLO) is a major virulence factor secreted by the intracellular pathogen Listeria monocytogenes, which plays a crucial role in the escape of bacteria from the phagosomal compartment. ...Two LLO variants were constructed: a dele …
The hly-encoded listeriolysin O (LLO) is a major virulence factor secreted by the intracellular pathogen Listeria monocytogenes, whic …
A hypermutator phenotype attenuates the virulence of Listeria monocytogenes in a mouse model.
Mérino D, Réglier-Poupet H, Berche P, Charbit A; European Listeria Genome Consortium. Mérino D, et al. Mol Microbiol. 2002 May;44(3):877-87. doi: 10.1046/j.1365-2958.2002.02929.x. Mol Microbiol. 2002. PMID: 11994166
Functional analysis of the mutSL locus was studied by constructing a double knock-out mutant. We showed that the deletion DeltamutSL induces: (i) a 100- to 1000-fold increase in the spontaneous mutation rate; and (ii) a 10- to 15-fold increase in the frequenc …
Functional analysis of the mutSL locus was studied by constructing a double knock-out mutant. We showed that the deletion DeltamutSL …
Differential roles of multiple signal peptidases in the virulence of Listeria monocytogenes.
Bonnemain C, Raynaud C, Réglier-Poupet H, Dubail I, Frehel C, Lety MA, Berche P, Charbit A. Bonnemain C, et al. Mol Microbiol. 2004 Mar;51(5):1251-66. doi: 10.1111/j.1365-2958.2004.03916.x. Mol Microbiol. 2004. PMID: 14982622
Most importantly, a mutant expressing only SipX was impaired in intracellular survival and strongly attenuated in the mouse (LD(50) of 10(7.2)), whereas, a mutant expressing only SipZ behaved like wild-type EGD in all the assays performed. ...This work constitutes t …
Most importantly, a mutant expressing only SipX was impaired in intracellular survival and strongly attenuated in the mouse (LD(50) o …
Role of the wbt locus of Francisella tularensis in lipopolysaccharide O-antigen biogenesis and pathogenicity.
Raynaud C, Meibom KL, Lety MA, Dubail I, Candela T, Frapy E, Charbit A. Raynaud C, et al. Infect Immun. 2007 Jan;75(1):536-41. doi: 10.1128/IAI.01429-06. Epub 2006 Oct 9. Infect Immun. 2007. PMID: 17030571 Free PMC article.
Francisella tularensis is a highly infectious bacterial pathogen, responsible for the zoonotic disease tularemia. We screened a bank of transposon insertion mutants of F. tularensis subsp. holarctica LVS for colony morphology alterations and selected a mutant …
Francisella tularensis is a highly infectious bacterial pathogen, responsible for the zoonotic disease tularemia. We screened a
The heat-shock protein ClpB of Francisella tularensis is involved in stress tolerance and is required for multiplication in target organs of infected mice.
Meibom KL, Dubail I, Dupuis M, Barel M, Lenco J, Stulik J, Golovliov I, Sjöstedt A, Charbit A. Meibom KL, et al. Mol Microbiol. 2008 Mar;67(6):1384-401. doi: 10.1111/j.1365-2958.2008.06139.x. Epub 2008 Feb 15. Mol Microbiol. 2008. PMID: 18284578
Francisella tularensis is a highly infectious bacterium causing the zoonotic disease tularaemia. The ability of F. tularensis to multiply and survive in macrophages is considered essential for its virulence. ...Promoter analysis shows that the transcriptional start is prec …
Francisella tularensis is a highly infectious bacterium causing the zoonotic disease tularaemia. The ability of F. tularensis to mult …
A novel receptor - ligand pathway for entry of Francisella tularensis in monocyte-like THP-1 cells: interaction between surface nucleolin and bacterial elongation factor Tu.
Barel M, Hovanessian AG, Meibom K, Briand JP, Dupuis M, Charbit A. Barel M, et al. BMC Microbiol. 2008 Sep 12;8:145. doi: 10.1186/1471-2180-8-145. BMC Microbiol. 2008. PMID: 18789156 Free PMC article.
In a pull-down assay, elongation factor Tu (EF-Tu), a GTP-binding protein involved in protein translation, usually found in cytoplasm, was recovered among LVS bacterial membrane proteins bound on RGG domain of nucleolin. A specific polyclonal murine antibody …
In a pull-down assay, elongation factor Tu (EF-Tu), a GTP-binding protein involved in protein translation, usually found in cy …
Glutathione provides a source of cysteine essential for intracellular multiplication of Francisella tularensis.
Alkhuder K, Meibom KL, Dubail I, Dupuis M, Charbit A. Alkhuder K, et al. PLoS Pathog. 2009 Jan;5(1):e1000284. doi: 10.1371/journal.ppat.1000284. Epub 2008 Jan 30. PLoS Pathog. 2009. PMID: 19158962 Free PMC article.
By screening a bank of HimarFT transposon mutants of the F. tularensis live vaccine strain (LVS) to isolate intracellular growth-deficient mutants, we selected one mutant in a gene encoding a putative gamma-glutamyl transpeptidase (GGT). ...Thus, the capacity …
By screening a bank of HimarFT transposon mutants of the F. tularensis live vaccine strain (LVS) to isolate intracellular growth-defi …
Hfq, a novel pleiotropic regulator of virulence-associated genes in Francisella tularensis.
Meibom KL, Forslund AL, Kuoppa K, Alkhuder K, Dubail I, Dupuis M, Forsberg A, Charbit A. Meibom KL, et al. Infect Immun. 2009 May;77(5):1866-80. doi: 10.1128/IAI.01496-08. Epub 2009 Feb 17. Infect Immun. 2009. PMID: 19223477 Free PMC article.
Hfq thus appears to be a new pleiotropic regulator of virulence in F. tularensis, acting mostly as a repressor, in contrast to the other regulators identified so far. Moreover, the results obtained suggest a novel regulatory mechanism for a subset of F …
Hfq thus appears to be a new pleiotropic regulator of virulence in F. tularensis, acting mostly as a repressor, in contrast to …
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