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The homeodomain-containing proteins: an update on their interacting partners.
Chariot A, Gielen J, Merville MP, Bours V. Chariot A, et al. Biochem Pharmacol. 1999 Dec 15;58(12):1851-7. doi: 10.1016/s0006-2952(99)00234-8. Biochem Pharmacol. 1999. PMID: 10591139 Review.
They share a highly conserved 60-amino-acid region (the "homeodomain"), which allows them to bind DNA and modulate the expression of multiple target genes, whose identities remain largely unknown. ...
They share a highly conserved 60-amino-acid region (the "homeodomain"), which allows them to bind DNA and modulate the expression of …
Deregulated expression of pro-survival and pro-apoptotic p53-dependent genes upon Elongator deficiency in colon cancer cells.
Cornez I, Creppe C, Gillard M, Hennuy B, Chapelle JP, Dejardin E, Merville MP, Close P, Chariot A. Cornez I, et al. Biochem Pharmacol. 2008 Jun 1;75(11):2122-34. doi: 10.1016/j.bcp.2008.03.006. Epub 2008 Mar 15. Biochem Pharmacol. 2008. PMID: 18430410
Elongator, a multi-subunit complex assembled by the IkappaB kinase-associated protein (IKAP)/hELP1 scaffold protein is involved in transcriptional elongation in the nucleus as well as in tRNA modifications in the cytoplasm. ...Moreover, Elongator deficiency causes increase …
Elongator, a multi-subunit complex assembled by the IkappaB kinase-associated protein (IKAP)/hELP1 scaffold protein is involved in tr …
Protein phosphorylation as a key mechanism for the regulation of BCL-3 activity.
Viatour P, Merville MP, Bours V, Chariot A. Viatour P, et al. Cell Cycle. 2004 Dec;3(12):1498-501. doi: 10.4161/cc.3.12.1328. Epub 2004 Dec 22. Cell Cycle. 2004. PMID: 15611665
Constitutive NF-kappaB activation, a hallmark of many human cancers, upregulates anti-apoptotic gene expression and therefore disrupts the balance between apoptosis and proliferation. ...The BCL-3 protein is another member of the IkappaB family and is overexpressed in a
Constitutive NF-kappaB activation, a hallmark of many human cancers, upregulates anti-apoptotic gene expression and therefore disrupt …
GSK3-mediated BCL-3 phosphorylation modulates its degradation and its oncogenicity.
Viatour P, Dejardin E, Warnier M, Lair F, Claudio E, Bureau F, Marine JC, Merville MP, Maurer U, Green D, Piette J, Siebenlist U, Bours V, Chariot A. Viatour P, et al. Mol Cell. 2004 Oct 8;16(1):35-45. doi: 10.1016/j.molcel.2004.09.004. Mol Cell. 2004. PMID: 15469820
The oncoprotein BCL-3 is a nuclear transcription factor that activates NF-kappaB target genes through formation of heterocomplexes with p50 or p52. ...This phosphorylation modulates its association with HDAC1, -3, and -6 and attenuates its oncogenicity by selectively contr …
The oncoprotein BCL-3 is a nuclear transcription factor that activates NF-kappaB target genes through formation of heterocomplexes wi …
Caspase-8-dependent HER-2 cleavage in response to tumor necrosis factor alpha stimulation is counteracted by nuclear factor kappaB through c-FLIP-L expression.
Benoit V, Chariot A, Delacroix L, Deregowski V, Jacobs N, Merville MP, Bours V. Benoit V, et al. Cancer Res. 2004 Apr 15;64(8):2684-91. doi: 10.1158/0008-5472.can-03-2914. Cancer Res. 2004. PMID: 15087380
The oncoprotein HER-2/neu is a prosurvival factor, and its overexpression has been correlated with poor prognosis in patients with breast cancer. We report that HER-2 is a new substrate for caspase-8 and that tumor necrosis factor alpha (TNF-alpha) stimulation leads …
The oncoprotein HER-2/neu is a prosurvival factor, and its overexpression has been correlated with poor prognosis in patients with br …
Deregulated NF-kappaB activity in haematological malignancies.
Keutgens A, Robert I, Viatour P, Chariot A. Keutgens A, et al. Biochem Pharmacol. 2006 Oct 30;72(9):1069-80. doi: 10.1016/j.bcp.2006.06.011. Epub 2006 Jul 18. Biochem Pharmacol. 2006. PMID: 16854381 Review.
Constitutive NF-kappaB activation is a common feature for most haematological malignancies and is therefore believed to be a crucial event for enhanced proliferation and survival of these malignant cells. ...
Constitutive NF-kappaB activation is a common feature for most haematological malignancies and is therefore believed to be a c …
20 years of NF-kappaB.
Chariot A. Chariot A. Biochem Pharmacol. 2006 Oct 30;72(9):1051-3. doi: 10.1016/j.bcp.2006.08.023. Epub 2006 Aug 30. Biochem Pharmacol. 2006. PMID: 16999938 No abstract available.
Role of IKK and ERK pathways in intrinsic inflammation of cystic fibrosis airways.
Verhaeghe C, Remouchamps C, Hennuy B, Vanderplasschen A, Chariot A, Tabruyn SP, Oury C, Bours V. Verhaeghe C, et al. Biochem Pharmacol. 2007 Jun 15;73(12):1982-94. doi: 10.1016/j.bcp.2007.03.019. Epub 2007 Mar 24. Biochem Pharmacol. 2007. PMID: 17466952
In cystic fibrosis (CF) patients, pulmonary inflammation is a major cause of morbidity and mortality and may precede bacterial colonization. ...Using different cystic fibrosis cell models, we first demonstrated that, beside a high constitutive nuclear factor of kapp …
In cystic fibrosis (CF) patients, pulmonary inflammation is a major cause of morbidity and mortality and may precede bacterial coloni …
Promoter-dependent effect of IKKalpha on NF-kappaB/p65 DNA binding.
Gloire G, Horion J, El Mjiyad N, Bex F, Chariot A, Dejardin E, Piette J. Gloire G, et al. J Biol Chem. 2007 Jul 20;282(29):21308-18. doi: 10.1074/jbc.M610728200. Epub 2007 May 30. J Biol Chem. 2007. PMID: 17537731
Further molecular studies demonstrated that the removal of chromatin-bound HDAC3, a histone deacetylase inhibiting p65 DNA binding, is differentially regulated by IKKalpha in a promoter-specific manner. ...We conclude that nuclear IKKalpha is required for p65 DNA bi …
Further molecular studies demonstrated that the removal of chromatin-bound HDAC3, a histone deacetylase inhibiting p65 DNA binding, i …
Raloxifene-induced myeloma cell apoptosis: a study of nuclear factor-kappaB inhibition and gene expression signature.
Olivier S, Close P, Castermans E, de Leval L, Tabruyn S, Chariot A, Malaise M, Merville MP, Bours V, Franchimont N. Olivier S, et al. Mol Pharmacol. 2006 May;69(5):1615-23. doi: 10.1124/mol.105.020479. Epub 2006 Feb 23. Mol Pharmacol. 2006. PMID: 16497877
Because multiple myeloma remains associated with a poor prognosis, novel drugs targeting specific signaling pathways are needed. ...In the present report, we studied the antitumor activity of raloxifene, a selective estrogen receptor modulator, on multiple myeloma c …
Because multiple myeloma remains associated with a poor prognosis, novel drugs targeting specific signaling pathways are needed. ...I …
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