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Using Human Plasma as an Assay Medium in Caco-2 Studies Improves Mass Balance for Lipophilic Compounds.
Katneni K, Pham T, Saunders J, Chen G, Patil R, White KL, Abla N, Chiu FCK, Shackleford DM, Charman SA. Katneni K, et al. Pharm Res. 2018 Sep 17;35(11):210. doi: 10.1007/s11095-018-2493-3. Pharm Res. 2018. PMID: 30225649 Free PMC article.
Simultaneous determination of OZ277, a synthetic 1,2,4-trioxolane antimalarial, and its polar metabolites in rat plasma using hydrophilic interaction chromatography.
Bhamidipati RK, Morizzi J, Chiu FC, Shackleford DM, Charman SA. Bhamidipati RK, et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Oct 1;877(27):2989-95. doi: 10.1016/j.jchromb.2009.07.015. Epub 2009 Jul 17. J Chromatogr B Analyt Technol Biomed Life Sci. 2009. PMID: 19646936
Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria.
Charman SA, Arbe-Barnes S, Bathurst IC, Brun R, Campbell M, Charman WN, Chiu FC, Chollet J, Craft JC, Creek DJ, Dong Y, Matile H, Maurer M, Morizzi J, Nguyen T, Papastogiannidis P, Scheurer C, Shackleford DM, Sriraghavan K, Stingelin L, Tang Y, Urwyler H, Wang X, White KL, Wittlin S, Zhou L, Vennerstrom JL. Charman SA, et al. Proc Natl Acad Sci U S A. 2011 Mar 15;108(11):4400-5. doi: 10.1073/pnas.1015762108. Epub 2011 Feb 7. Proc Natl Acad Sci U S A. 2011. PMID: 21300861 Free PMC article.
Preclinical comparison of intravenous melphalan pharmacokinetics administered in formulations containing either (SBE)7 m-β-cyclodextrin or a co-solvent system.
Koltun M, Morizzi J, Katneni K, Charman SA, Shackleford DM, McIntosh MP. Koltun M, et al. Biopharm Drug Dispos. 2010 Nov;31(8-9):450-4. doi: 10.1002/bdd.725. Biopharm Drug Dispos. 2010. PMID: 20865695
Lymphatic absorption of subcutaneously administered proteins: influence of different injection sites on the absorption of darbepoetin alfa using a sheep model.
Kota J, Machavaram KK, McLennan DN, Edwards GA, Porter CJ, Charman SA. Kota J, et al. Drug Metab Dispos. 2007 Dec;35(12):2211-7. doi: 10.1124/dmd.107.015669. Epub 2007 Sep 17. Drug Metab Dispos. 2007. PMID: 17875672
Pharmacokinetics and brain uptake of AM-36, a novel neuroprotective agent, following intravenous administration to rats.
Nicolazzo JA, Nguyen TT, Katneni K, Steuten JA, Smith G, Jarrott B, Callaway JK, Charman SA. Nicolazzo JA, et al. J Pharm Pharmacol. 2008 Feb;60(2):171-8. doi: 10.1211/jpp.60.2.0005. J Pharm Pharmacol. 2008. PMID: 18237464
Probing a potential in vivo drug-excipient interaction: temporal effects of a modified β-cyclodextrin on the intravenous pharmacokinetics of a model high-affinity drug ligand.
Mannila A, Morizzi J, Nguyen TT, Charman SA, McIntosh MP, Shackleford DM. Mannila A, et al. J Pharm Sci. 2012 Sep;101(9):3381-9. doi: 10.1002/jps.23177. Epub 2012 May 1. J Pharm Sci. 2012. PMID: 22549698
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