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Intestinal inhibition of the Na+/H+ exchanger 3 prevents cardiorenal damage in rats and inhibits Na+ uptake in humans.
Spencer AG, Labonte ED, Rosenbaum DP, Plato CF, Carreras CW, Leadbetter MR, Kozuka K, Kohler J, Koo-McCoy S, He L, Bell N, Tabora J, Joly KM, Navre M, Jacobs JW, Charmot D. Spencer AG, et al. Among authors: charmot d. Sci Transl Med. 2014 Mar 12;6(227):227ra36. doi: 10.1126/scitranslmed.3007790. Sci Transl Med. 2014. PMID: 24622516 Clinical Trial.
Gastrointestinal Inhibition of Sodium-Hydrogen Exchanger 3 Reduces Phosphorus Absorption and Protects against Vascular Calcification in CKD.
Labonté ED, Carreras CW, Leadbetter MR, Kozuka K, Kohler J, Koo-McCoy S, He L, Dy E, Black D, Zhong Z, Langsetmo I, Spencer AG, Bell N, Deshpande D, Navre M, Lewis JG, Jacobs JW, Charmot D. Labonté ED, et al. Among authors: charmot d. J Am Soc Nephrol. 2015 May;26(5):1138-49. doi: 10.1681/ASN.2014030317. Epub 2014 Nov 17. J Am Soc Nephrol. 2015. PMID: 25404658 Free PMC article.
Preclinical and Healthy Volunteer Studies of Potential Drug-Drug Interactions Between Tenapanor and Phosphate Binders.
Johansson S, Leonsson-Zachrisson M, Knutsson M, Spencer AG, Labonté ED, Deshpande D, Kohler J, Kozuka K, Charmot D, Rosenbaum DP. Johansson S, et al. Among authors: charmot d. Clin Pharmacol Drug Dev. 2017 Sep;6(5):448-456. doi: 10.1002/cpdd.307. Epub 2016 Oct 26. Clin Pharmacol Drug Dev. 2017. PMID: 27654985 Free PMC article. Clinical Trial.
Development and Characterization of a Human and Mouse Intestinal Epithelial Cell Monolayer Platform.
Kozuka K, He Y, Koo-McCoy S, Kumaraswamy P, Nie B, Shaw K, Chan P, Leadbetter M, He L, Lewis JG, Zhong Z, Charmot D, Balaa M, King AJ, Caldwell JS, Siegel M. Kozuka K, et al. Among authors: charmot d. Stem Cell Reports. 2017 Dec 12;9(6):1976-1990. doi: 10.1016/j.stemcr.2017.10.013. Epub 2017 Nov 16. Stem Cell Reports. 2017. PMID: 29153987 Free PMC article.
Non-systemic drugs: a critical review.
Charmot D. Charmot D. Curr Pharm Des. 2012;18(10):1434-45. doi: 10.2174/138161212799504858. Curr Pharm Des. 2012. PMID: 22300258 Free PMC article. Review.
40 results