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Structures of Cas9 endonucleases reveal RNA-mediated conformational activation.
Jinek M, Jiang F, Taylor DW, Sternberg SH, Kaya E, Ma E, Anders C, Hauer M, Zhou K, Lin S, Kaplan M, Iavarone AT, Charpentier E, Nogales E, Doudna JA. Jinek M, et al. Among authors: charpentier e. Science. 2014 Mar 14;343(6176):1247997. doi: 10.1126/science.1247997. Epub 2014 Feb 6. Science. 2014. PMID: 24505130 Free PMC article.
Bridge helix arginines play a critical role in Cas9 sensitivity to mismatches.
Bratovič M, Fonfara I, Chylinski K, Gálvez EJC, Sullivan TJ, Boerno S, Timmermann B, Boettcher M, Charpentier E. Bratovič M, et al. Among authors: charpentier e. Nat Chem Biol. 2020 May;16(5):587-595. doi: 10.1038/s41589-020-0490-4. Epub 2020 Mar 2. Nat Chem Biol. 2020. PMID: 32123387
Small RNAs in streptococci.
Le Rhun A, Charpentier E. Le Rhun A, et al. Among authors: charpentier e. RNA Biol. 2012 Apr;9(4):414-26. doi: 10.4161/rna.20104. Epub 2012 Apr 1. RNA Biol. 2012. PMID: 22546939 Review.
182 results