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Oral immunization of interleukin-4 (IL-4) knockout mice with a recombinant Salmonella strain or cholera toxin reveals that CD4+ Th2 cells producing IL-6 and IL-10 are associated with mucosal immunoglobulin A responses.
Okahashi N, Yamamoto M, Vancott JL, Chatfield SN, Roberts M, Bluethmann H, Hiroi T, Kiyono H, McGhee JR. Okahashi N, et al. Infect Immun. 1996 May;64(5):1516-25. doi: 10.1128/IAI.64.5.1516-1525.1996. Infect Immun. 1996. PMID: 8613355 Free PMC article.
TT-specific CD4+ T cells from spleen or Peyer's patches produced gamma interferon, indicative of Th1 responses; however, IL-6 and IL-10 were also seen. ...
TT-specific CD4+ T cells from spleen or Peyer's patches produced gamma interferon, indicative of Th1 responses; however, IL-6 and IL- …
Characterization of the T- and B-cell immune response to a new recombinant pre-S1, pre-S2 and SHBs antigen containing hepatitis B vaccine (Hepagene); evidence for superior anti-SHBs antibody induction in responder mice.
Jones CD, Page M, Bacon A, Cahill E, Bentley M, Chatfield SN. Jones CD, et al. J Viral Hepat. 1998 Nov;5 Suppl 2:5-8. doi: 10.1046/j.1365-2893.1998.0050s2005.x. J Viral Hepat. 1998. PMID: 9857353
Protection against Leishmania major infection in genetically susceptible BALB/c mice by gp63 delivered orally in attenuated Salmonella typhimurium (AroA- AroD-).
Xu D, McSorley SJ, Chatfield SN, Dougan G, Liew FY. Xu D, et al. Immunology. 1995 May;85(1):1-7. Immunology. 1995. PMID: 7635511 Free PMC article.
The gene encoding the Leishmania major (L. major) promastigote surface glycoprotein, gp63, was introduced into the Salmonella typhimurium (S. typhimurium) aroA- aroD- live oral vaccine strain BRD509 and expressed under the control of a constitutive tac promoter in plasmid …
The gene encoding the Leishmania major (L. major) promastigote surface glycoprotein, gp63, was introduced into the Salmonella typhimurium ( …
Regulation of mucosal and systemic antibody responses by T helper cell subsets, macrophages, and derived cytokines following oral immunization with live recombinant Salmonella.
VanCott JL, Staats HF, Pascual DW, Roberts M, Chatfield SN, Yamamoto M, Coste M, Carter PB, Kiyono H, McGhee JR. VanCott JL, et al. J Immunol. 1996 Feb 15;156(4):1504-14. J Immunol. 1996. PMID: 8568254
To assess Th1-and Th2-type responses, CD4+ T cells from Peyer's patches and spleen were restimulated in vitro, and cytokine-specific ELISPOT, ELISA, and reverse transcriptase-PCR assays were used to assess cytokine patterns. ...
To assess Th1-and Th2-type responses, CD4+ T cells from Peyer's patches and spleen were restimulated in vitro, and cytokine-specific …
T-cell and antibody response characterisation of a new recombinant pre-S1, pre-S2 and SHBs antigen-containing hepatitis B vaccine; demonstration of superior anti-SHBs antibody induction in responder mice.
Jones CD, Page M, Bacon A, Cahill E, Bentley M, Chatfield SN. Jones CD, et al. Vaccine. 1999 Jun 4;17(20-21):2528-37. doi: 10.1016/s0264-410x(99)00061-4. Vaccine. 1999. PMID: 10418899
The incidence of non-responders to hepatitis B (HB) virus SHBs antigen (Ag) vaccines has prompted the development of pre-S containing vaccines. ...
The incidence of non-responders to hepatitis B (HB) virus SHBs antigen (Ag) vaccines has prompted the development of pre-S containing …
Immune responses in calves immunised orally or subcutaneously with a live Salmonella typhimurium aro vaccine.
Villarreal-Ramos B, Manser J, Collins RA, Dougan G, Chatfield SN, Howard CJ. Villarreal-Ramos B, et al. Vaccine. 1998 Jan;16(1):45-54. doi: 10.1016/s0264-410x(97)00156-4. Vaccine. 1998. PMID: 9607008
Calves were protected against virulent S. typhimurium challenge following administration of a single oral dose of live BRD562 vaccine. ...These studies show that the S. typhimurium vaccine strain BRD562 is capable of inducing both humoral and cellular immune respons …
Calves were protected against virulent S. typhimurium challenge following administration of a single oral dose of live BRD562 vaccine …
Live Salmonella as vaccines and carriers of foreign antigenic determinants.
Chatfield SN, Strugnell RA, Dougan G. Chatfield SN, et al. Vaccine. 1989 Dec;7(6):495-8. doi: 10.1016/0264-410x(89)90271-5. Vaccine. 1989. PMID: 2481908 Review.
Oral vaccination of calves against experimental salmonellosis using a double aro mutant of Salmonella typhimurium.
Jones PW, Dougan G, Hayward C, Mackensie N, Collins P, Chatfield SN. Jones PW, et al. Vaccine. 1991 Jan;9(1):29-34. doi: 10.1016/0264-410x(91)90313-u. Vaccine. 1991. PMID: 2008797
This study suggests that vaccination with an attenuated strain of S. typhimurium harbouring mutations in two aro genes is a safe and effective way of protecting young calves against experimental S. typhimurium infection....
This study suggests that vaccination with an attenuated strain of S. typhimurium harbouring mutations in two aro genes is a safe and …
Evaluation of Salmonella typhimurium strains harbouring defined mutations in htrA and aroA in the murine salmonellosis model.
Chatfield SN, Strahan K, Pickard D, Charles IG, Hormaeche CE, Dougan G. Chatfield SN, et al. Microb Pathog. 1992 Feb;12(2):145-51. doi: 10.1016/0882-4010(92)90117-7. Microb Pathog. 1992. PMID: 1584006
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